Article
Oncology
Javid Sadri Nahand, Khadijeh Khanaliha, Hamed Mirzaei, Mohsen Moghoofei, Hossein Bannazadeh Baghi, Maryam Esghaei, Ali Reza Khatami, Maryam Fatemipour, Farah Bokharaei-Salim
Summary: The study evaluated the potential role of HPV and EBV coinfection in prostate cancer development. The findings suggest that HPV/EBV coinfection may influence tumor development and progression through modulation of cellular behaviors.
Article
Biochemistry & Molecular Biology
Karim Nagi, Ishita Gupta, Nawaf Jurdi, Amber Yasmeen, Semir Vranic, Gerald Batist, Ala-Eddin Al Moustafa
Summary: Colorectal cancer is the third most common cause of cancer-related deaths worldwide. High-risk HPVs and EBV were found to have a relatively high prevalence in CRC tissue samples, with HPV present in 64% and EBV in 29% of Lebanese cohort. The study also revealed the most frequent high-risk HPV types in CRC in the Lebanese cohort.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Otorhinolaryngology
Shannon S. Wu, Bonnie Chen, Christopher W. Fleming, Akeesha A. Shah, Christopher C. Griffith, Chaim Domb, Chandana A. Reddy, Shauna R. Campbell, Neil M. Woody, Eric D. Lamarre, Robert R. Lorenz, Brandon L. Prendes, Joseph Scharpf, Larissa Schwartzman, Jessica L. Geiger, Shlomo A. Koyfman, Jamie A. Ku
Summary: The prognostic significance of Epstein-Barr virus (EBV) and human papillomavirus (HPV) status in nasopharyngeal cancer (NPC) remains unclear. This retrospective study analyzed NPC cases from 2000 to 2019 and found that EBV+ NPC tumors were seen in younger, healthier patients compared to HPV+ and EBV- tumors. The association of viral status with overall survival (OS) was insignificant after adjusting for age and Karnofsky Performance Scale (KPS).
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Biotechnology & Applied Microbiology
Ishita Gupta, Monika Ulamec, Melita Peric-Balja, Snjezana Ramic, Ala-Eddin Al Moustafa, Semir Vranic, Halema F. Al-Farsi
Summary: Breast cancer is the most frequent disease among women worldwide, with the triple-negative subtype accounting for a significant percentage. Recent studies suggest the potential role of oncoviruses in breast cancer pathogenesis. This study found high detection rates of high-risk HPVs and EBV in patients with triple-negative breast cancer, as well as a presence of MMTV.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Xueyi Zheng, Ruixuan Wang, Xinke Zhang, Yan Sun, Haohuan Zhang, Zihan Zhao, Yuanhang Zheng, Jing Luo, Jiangyu Zhang, Hongmei Wu, Dan Huang, Wenbiao Zhu, Jianning Chen, Qinghua Cao, Hong Zeng, Rongzhen Luo, Peng Li, Lilong Lan, Jingping Yun, Dan Xie, Wei-Shi Zheng, Junhang Luo, Muyan Cai
Summary: This study introduces a deep convolutional neural network called EBVNet and its fusion with pathologists for predicting Epstein-Barr virus-associated gastric cancer (EBVaGC) from histopathology. EBVNet shows high accuracy in discriminating EBVaGC and the human-machine fusion significantly improves diagnostic performance.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Rances Blanco, Diego Carrillo-Beltran, Alejandro H. Corvalan, Francisco Aguayo
Summary: High-risk human papillomaviruses (HR-HPVs) and Epstein-Barr virus (EBV) are oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). Potential cooperation between HR-HPV and EBV for HNC development is plausible and requires further investigation.
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Khalid Ahmed, Alisalman Sheikh, Saira Fatima, Ghulam Haider, Kulsoom Ghias, Farhat Abbas, Nouman Mughal, Syed Hani Abidi
Summary: This study identified the presence of Epstein-Barr virus (EBV) in prostate cancer and benign prostatic hyperplasia (BPH) samples, with a higher prevalence in prostate cancer samples. The EBV-positive samples exhibited higher Gleason scores, suggesting a potential link between EBV and the onset/progression of prostate cancer. The study also found variable expression patterns of latency-associated genes in EBV-positive samples.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, Research & Experimental
Jose Damian Gomez-Archila, Jose Arellano-Galindo, Carmen Palacios-Reyes, Ana Maria Espinosa-Garcia, Patricia Garcia Alonso-Themann, Juan Xicohtencatl-Cortes, Saraa A. Ochoa, Ariadnna Cruz-Cordova, Icela Palma-Lara
Summary: Epstein-Barr virus (EBV) is an oncovirus associated with various neoplasms, including breast cancer (BC), and its oncogenesis is influenced by viral molecules that manipulate cellular machinery, evade the immune system, block apoptosis processes, promote cell survival and metastasis. Epigenetic alterations and signaling pathway disruptions also contribute to cancer risk. The presence of EBV in BC may be crucial under specific conditions. This review aims to analyze these variables and improve the understanding of EBV's involvement in BC.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Oncology
Peter Julius, Stepfanie N. Siyumbwa, Phyllis Moonga, Fred Maate, Trevor Kaile, Gleb Haynatski, Veenu Minhas, Jazmine Snow, Kerstin Peterson, Patience Gihozo, Sam Streeter, Salan Kaur, Annika Evans, Daniela Gonzalez, Kandali Samwel, Guobin Kang, John T. West, Charles Wood, Peter C. Angeletti
Summary: This study assessed the frequency of oncogenic viruses in ocular surface squamous neoplasia (OSSN) using immunohistochemistry and polymerase chain reaction. The results showed that Epstein-Barr virus (EBV) may play a potential causal role in OSSN, while the role of human papillomavirus (HPV) was not clearly established.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Munetoshi Hinata, Tetsuo Ushiku
Summary: A histology-based deep learning model was constructed to efficiently screen EBV and MSI/dMMR subtypes in gastric cancers, showing high accuracy in detecting the subgroup and highlighting intraepithelial lymphocytosis as a discriminative characteristic shared by EBV and MSI/dMMR tumors. This model offers a potential economical and less time-consuming alternative for stratifying patients who respond to ICIs.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Arghavan Zebardast, Sadra S. Tehrani, Tayebeh Latifi, Farzin Sadeghi
Summary: EBV-encoded miRNAs play a crucial role in the pathogenesis of EBVaGC, participating in carcinogenesis and the progression of malignancies by regulating gene expression and other activities.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Microbiology
Beniamin Oskar Grabarek, Piotr Ossowski, Justyna Czarniecka, Mateusz Ozog, Justyna Prucnal, Ireneusz Dziuba, Aleksander Ostenda, Konrad Dziobek, Dariusz Boron, Wojciech Peszek, Piotr Kras, Szymon Januszyk, Maciej Dabala, Tomasz Kasela, Marcin Oplawski
Summary: The purpose of this study was to evaluate the relationship between HPV16/18, EBV, and HCMV infections and ovarian cancer. Real-time PCR was used to detect HPV, EBV, and HCMV in tumor tissue and normal tissue of the participants. The results showed that HCMV infection was significantly associated with an increased risk of endometrial cancer, while HPV16, HPV18, and EBV were associated with a higher risk of ovarian cancer.
Article
Microbiology
Sven Borchmann
Summary: By analyzing over 3000 whole genome sequencing datasets, researchers identified potential roles of bacteria and viruses in cancer development, discovered new associations, and found significant differences in patient and tumor phenotypes associated with specific microorganisms.
Review
Microbiology
Julio C. Osorio, Rances Blanco, Alejandro H. Corvalan, Juan P. Munoz, Gloria M. Calaf, Francisco Aguayo
Summary: Lung cancer is the leading cause of cancer death worldwide. Besides smoking, other environmental factors and viral infections are also associated with lung cancer. This review examines the potential relationship between EBV and lung cancer based on epidemiological and experimental evidence, and proposes potential mechanisms.