Article
Medicine, General & Internal
Zefeng Li, Hu Ren, Xiaojie Zhang, Chongyuan Sun, He Fei, Zheng Li, Chunguang Guo, Susheng Shi, Yingtai Chen, Dongbing Zhao
Summary: This study compared the characteristics and survival outcomes between patients with gastric large-cell neuroendocrine carcinoma (GLNEC) and gastric small-cell neuroendocrine carcinoma (GSNEC), and concluded that there was no significant statistical difference in prognosis between the two types despite their different cell morphologies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Mayuko Kanayama, Jun Luo
Summary: The treatment landscape of prostate cancer has changed significantly with the introduction of novel systemic therapies that target the androgen receptor (AR), aiming to delay disease progression. However, some tumors may develop drug resistance post treatment, highlighting the need for further research and precise definitions of emerging disease entities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ziwei Wang, Tao Wang, Danni Hong, Baijun Dong, Yan Wang, Huaqiang Huang, Wenhui Zhang, Bijun Lian, Boyao Ji, Haoqing Shi, Min Qu, Xu Gao, Daofeng Li, Colin Collins, Gonghong Wei, Chuanliang Xu, Hyung Joo Lee, Jialiang Huang, Jing Li
Summary: This study characterized ADPC and NEPC in prostate tumors using scRNA-seq and identified NEPC-specific gene expression signatures. The findings revealed different paths by which NEPC diverges from ADPC and inferred a hierarchical transcription factor network involved in NEPC progression.
Article
Oncology
Jonathan Chou, Emily A. Egusa, Sinan Wang, Michelle L. Badura, Fei Lee, Anil P. Bidkar, Jun Zhu, Tanushree Shenoy, Kai Trepka, Troy M. Robinson, Veronica Steri, Jiaoti Huang, Yuzhuo Wang, Eric J. Small, Emily Chan, Bradley A. Stohr, Alan Ashworth, Brant Delafontaine, Sylvie Rottey, Keegan S. Cooke, Nooshin Hashemi Sadraei, Brian Yu, Mark Salvati, Julie M. Bailis, Felix Y. Feng, Robert R. Flavell, Rahul Aggarwal
Summary: The expression of DLL3 in de novo and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer is associated with reduced survival. A PET agent, [89Zr]-DFO-DLL3-scFv, has been developed to detect DLL3 levels in mouse SCNC models. The DLL3-targeted bispecific T-cell engager (BiTE) immunotherapy, AMG 757 (tarlatamab), exhibits potent and durable antitumor activity in patient-derived xenograft models.
Article
Endocrinology & Metabolism
Christopher E. Wee, Brian A. Costello, Jacob J. Orme, J. Fernando Quevedo, Lance C. Pagliaro
Summary: Chemotherapy in combination with immunotherapy has shown better survival outcomes compared to chemotherapy alone in extensive stage small cell lung cancer, but the addition of immunotherapy (atezolizumab) to chemotherapy (carboplatin and etoposide) did not improve survival outcomes in patients with small cell or neuroendocrine carcinoma of the prostate.
Article
Oncology
Jin-Dong Li, Cheng-Yan Jin, Yan Zhang, Hang Guo, Guang-Lei Zhang, Chun-Guang Wang
Summary: This case report describes a patient with lung cancer who experienced histopathological transformation from squamous-cell carcinoma to large cell neuroendocrine carcinoma with a small fraction of small cell carcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yanan Wang, Fangfei Qian, Ya Chen, Zhengyu Yang, Minjuan Hu, Jun Lu, Yanwei Zhang, Wei Zhang, Lei Cheng, Baohui Han
Summary: This study compared the clinical features, mutation status of driver genes, and prognosis between combined LCNEC and combined SCLC, revealing significant differences and a more favorable outcome for patients with combined LCNEC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Susanne Grunewald, Lillian R. Klug, Thomas Muhlenberg, Jonas Lategahn, Johanna Falkenhorst, Ajia Town, Christiane Ehrt, Eva Wardelmann, Wolfgang Hartmann, Hans-Ulrich Schildhaus, Juergen Treckmann, Jonathan A. Fletcher, Sascha Jung, Paul Czodrowski, Stephen Miller, Oleg Schmidt-Kittler, Daniel Rauh, Michael C. Heinrich, Sebastian Bauer
Summary: Avapritinib shows substantial clinical activity in patients with PDGFRA D842V genotype, but secondary resistance has been observed. Some PDGFRA mutant patients develop secondary mutations that interfere with avapritinib binding, leading to resistance.
Review
Oncology
Sheng Xu, Lei Xu, Peng Cao, Shiyun Yao, Tingming Wu, Xinming Hu, Hualei Chen, Jun Gu, Xianping Che
Summary: Small cell neuroendocrine carcinoma (SCNEC) of the ureter is a rare and highly aggressive tumor, with poor prognosis. Collision with other pathological types, such as squamous cell carcinoma, is extremely rare. Management typically involves surgery, with careful monitoring for recurrence and distant metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Li-Yu Chen, Shih-Lun Chang, Wen-Ying Lee
Summary: Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses is a rare and aggressive tumor with various treatment modalities, most commonly involving multimodality therapy. Further research is needed to establish standardized treatment protocols due to the complexity of the disease and lack of established algorithms.
Editorial Material
Obstetrics & Gynecology
Emmanouil Kalampokas, Georgios Giannis, Paraskevi Alexandrou, Evangelos Kritikos, Olga Triantafyllidou, Theodoros Kalampokas, Nikolaos Vlahos, Spyridon Marinis
Summary: This paper presents a rare case of small-cell neuroendocrine carcinoma of the vagina and highlights the lack of consensus on its treatment. The establishment of data-collection registries is recommended to enhance understanding and optimize management of this condition.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Immunology
JunLing Lu, Ya Li, Jun Wang
Summary: Cervical SCNEC is a rare and highly malignant tumor with low incidence and high association with high-risk HPV infection. Patients are prone to lymph node invasion and usually present with local or distant metastasis. Multimodal treatment can improve tumor-free survival, but prognosis remains poor. Further research is needed to explore more effective therapies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Keyu Li, Jialong Yuan, Yichen Li, Hao Zhang, Xubao Liu, Nengwen Ke
Summary: This study reports a rare case of pancreatic neuroendocrine carcinoma patient who achieved radical surgery after receiving neoadjuvant therapy, providing a new treatment option for similar patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Paulina Gonzalez, Sashi Debnath, Yu-An Chen, Elizabeth Hernandez, Preeti Jha, Marianna Dakanali, Jer-Tsong Hsieh, Xiankai Sun
Summary: The study reports a small molecule prodrug conjugate (T-SMPDC) for targeted positron emission tomography (PET) imaging and chemotherapy of neuroendocrine prostate cancer (NEPC). The T-SMPDC is designed with a chelating moiety for PET imaging, a targeting peptide for somatostatin receptor 2 (SSTR2) in the tumor microenvironment, and an antagonist of sphingosine kinase 1. In vivo experiments showed selective binding and internalization of the T-SMPDC in SSTR2-positive prostate cancer xenografts, and release of the cytotoxic molecule FTY720. These findings validate the design concept of the T-SMPDC for targeted diagnosis and therapy of NEPC.
Article
Medicine, General & Internal
Li Pang, Shizhuo Wang
Summary: This study aimed to evaluate the prevalence of independent predictors related to the prognosis and overall survival of patients with small-cell neuroendocrine carcinomas of the gynecologic tract. The study found that advanced age, stage III and IV cancer, and no chemotherapy treatment may be predictors of poor prognosis for cervical small-cell neuroendocrine carcinoma. Stage III and IV cancer and lack of surgery, radiotherapy, or chemotherapy were identified as potential predictors of poor prognosis in patients with ovarian small-cell neuroendocrine carcinoma. The study also provided survival rates for different types of small-cell neuroendocrine carcinomas.
FRONTIERS IN MEDICINE
(2022)