Article
Surgery
Jinge Zhao, Guangxi Sun, Fengnian Zhao, Junru Chen, Sha Zhu, Nanwei Xu, Haoyang Liu, Jiayu Liang, Xu Hu, Xingming Zhang, Yuchao Ni, Jindong Dai, Zhipeng Wang, Pengfei Shen, Zhenhua Liu, Ni Chen, Jiyan Liu, Hao Zeng
Summary: This study aimed to investigate the treatment effect of radical prostatectomy (RP) and external beam radiation therapy (EBRT) in nonadenocarcinoma prostate cancer (PCa) patients. The results showed that patients with small cell neuroendocrine carcinoma (SCNC) and neuroendocrine differentiation (NED) had the worst prognosis, while patients with ductal carcinoma (DA) also had poorer survival outcomes. Patients with mucinous adenocarcinoma (MA) and signet ring cell carcinoma (SRCC) had comparable clinical outcomes to those with adenocarcinoma.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Jose Francisco Suarez, Victor Zamora, Olatz Garin, Cristina Gutierrez, Angels Pont, Yolanda Pardo, Alai Goni, Alfonso Marino, Asuncion Hervas, Ismael Herruzo, Patricia Cabrera, Gemma Sancho, Javier Ponce de Leon, Victor Macias, Ferran Guedea, Francesc Vigues, Manuel Castells, Montse Ferrer
Summary: This study compared the effectiveness of radical prostatectomy, brachytherapy, and external radiotherapy at ten years of follow-up. The findings showed that brachytherapy and external radiotherapy were not associated with decreased overall survival but had higher risk of biochemical recurrence compared to radical prostatectomy. External radiotherapy also had higher prostate cancer-specific mortality. These results provide valuable information for clinical decision-making.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yvonka van Wijk, Bram Ramaekers, Ben G. L. Vanneste, Iva Halilaj, Cary Oberije, Avishek Chatterjee, Tom Marcelissen, Arthur Jochems, Henry C. Woodruff, Philippe Lambin
Summary: This study aims to develop a DSS system to assist in selecting treatment for low- to intermediate-risk prostate cancer, improve quality of life for patients and be utilized in in silico trials.
Article
Urology & Nephrology
Wonchul Lee, Bumjin Lim, Yoon Soo Kyung, Choung-Soo Kim
Summary: Comparison of oncological outcomes between radical prostatectomy and radiation therapy plus androgen deprivation therapy for clinical T3b prostate cancer showed that radical prostatectomy had significantly longer cancer-specific survival than radiation therapy plus androgen deprivation therapy.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Endocrinology & Metabolism
Mike Wenzel, Christoph Wurnschimmel, Francesco Chierigo, Zhe Tian, Shahrokh F. Shariat, Carlo Terrone, Fred Saad, Derya Tilki, Markus Graefen, Philipp Mandel, Luis A. Kluth, Felix K. H. Chun, Pierre I. Karakiewicz
Summary: The study found that elderly prostate cancer patients treated with a combination of radical prostatectomy and external beam radiation therapy (RP and EBRT) exhibited higher rates of other cause mortality (OCM), raising concerns about the necessity of combination therapy in elderly PCa patients and highlighting the need for better patient selection when considering combination therapy.
Review
Oncology
Christopher Hayden, Syed Rahman, Soum Lokeshwar, Ankur Choksi, Isaac Y. Y. Kim
Summary: About 15% of prostate cancer patients have lymph node metastases at the time of radical prostatectomy, but there is no universally accepted standard of care for these patients. Treatment options range from observation to a combination of adjuvant androgen deprivation therapy and radiation therapy. Recent studies show that patients treated with adjuvant radiation therapy have lower mortality rates.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Oncology
Barry W. Goy, Raoul Burchette
Summary: This study compared the 10-year late complications of radical prostatectomy (RP), external-beam radiation therapy (EBRT), and brachytherapy (BT) in intermediate-risk prostate cancer patients. It was found that BT had a lower prevalence of severe urinary complications, while RP had a higher prevalence of erectile dysfunction devices (EDD).
Article
Oncology
Christian Schaufler, Sumedh Kaul, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Simon Kim, Joaquim Bellmunt, Irving Kaplan, Aria F. Olumi, Boris Gershman
Summary: This study compared the effectiveness of adjuvant radiotherapy (aRT) versus observation in patients with pN1 prostate cancer through a simulated pragmatic trial. The study found that aRT only improved overall survival in patients with Gleason 8-10 disease, >=2 positive lymph nodes, or negative surgical margins.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Valentin H. Meissner, Cornelia Peter, Donna P. Ankerst, Stefan Schiele, Juergen E. Gschwend, Kathleen Herkommer, Andreas Dinkel
Summary: This longitudinal study investigates the course and predictors of prostate cancer-related anxiety in long-term survivors treated by radical prostatectomy. The study found that prostate cancer-related anxiety remains stable over 5 years, and factors such as initial anxiety levels, biochemical recurrence, and psychological well-being predict future anxiety.
Article
Oncology
Chanan Reitblat, Aaron Fleishman, Irving A. Kaplan, Kristian D. Stensland, Anthony D'Amico, Aria F. Olumi, Andrew A. Wagner, Peter K. Chang, Simon P. Kim, Ruslan Korets, Boris Gershman
Summary: This study aimed to emulate a hypothetical target clinical trial comparing radical prostatectomy (RP) with external beam radiotherapy (EBRT) for high-grade, clinically localized prostate cancer. The results showed that RP was associated with improved overall survival (OS) compared to EBRT+ADT in men with these conditions, across various categories of Gleason score, PSA, clinical T stage, age, and Charlson comorbidity index examined.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Endocrinology & Metabolism
Benedikt Hoeh, Christoph Wuernschimmel, Rocco S. Flammia, Benedikt Horlemann, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F. Shariat, Luis A. Kluth, Philipp Mandel, Felix K. H. Chun, Pierre Karakiewicz
Summary: The study found that radical prostatectomy (RP) had a lower 5-year cancer-specific mortality rate compared to external beam radiotherapy (EBRT) in NCCN high-risk patients and Johns Hopkins University (JHU) very high-risk patients. However, there was no significant difference in cancer-specific mortality between RP and EBRT in JHU high-risk patients.
Article
Urology & Nephrology
Benedikt Hoeh, Jan L. Hohenhorst, Rocco Flammia, Benedikt Horlemann, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F. Shariat, Luis A. Kluth, Andreas Becker, Felix K. H. Chun, Pierre Karakiewicz
Summary: The study aimed to compare cancer-specific mortality rates in Hispanic/Latino prostate cancer patients based on different treatment types (radical prostatectomy or external beam radiotherapy). The results indicated a potential benefit of radical prostatectomy over external beam radiotherapy in high-risk patients, but this difference was no longer statistically significant after adjusting for patient and tumor characteristics.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Jaehun Jung, Gi Hwan Bae, Jae Heon Kim, Jaehong Kim
Summary: This study aimed to evaluate the clinical impact of robot-assisted radical prostatectomy (RARP) on health outcomes in Korean patients with prostate cancer (PCa). The study found that RARP had a higher risk of overall mortality within 3 and 12 months compared to radical prostatectomy (RP). The RARP group in hospitals with the largest PCa surgery volume had higher mortality rates and more surgical complications than the total RARP patients. The study suggests that RARP may not be superior to RP, possibly due to increased robotic surgery in the elderly.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Hann-Hsiang Chao, Payal D. Soni, Bassam Dahman, Spiro C. Stilianoudakis, Hampton Ford, Raj Singh, Stephen J. Freedland, Drew Moghanaki, Neha Vapiwala, Michael G. Chang
Summary: This study compared the outcomes of radical prostatectomy (RP) and external beam radiation therapy with androgen deprivation therapy (EBRT+ADT) in patients with nonmetastatic Gleason Score 9 and 10 prostate cancer (GS 9-10 PCa). The results showed higher overall survival rates among patients treated with RP, while distant metastasis-free survival rates were similar between RP and EBRT+ADT. Furthermore, improved outcomes were observed in Black patients receiving EBRT+ADT.
Article
Endocrinology & Metabolism
Francesco Chierigo, Marco Borghesi, Christoph Wuernschimmel, Rocco S. Flammia, Benedikt Horlemann, Gabriele Sorce, Benedikt Hoeh, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Francesco Montorsi, Felix K. H. Chun, Shahrokh F. Shariat, Guglielmo Mantica, Nazareno Suardi, Carlo Terrone, Pierre Karakiewicz
Summary: This study compared the overall mortality, cancer-specific mortality, and other cause mortality between radical prostatectomy and radiotherapy in clinical node-positive prostate cancer patients.