Article
Environmental Sciences
Huiling Chen, Jiangbin Li, Yanchao Zhang, Wei Zhang, Xing Li, Huanwen Tang, Yungang Liu, Tianlan Li, Haoqi He, Bohai Du, Li Li, Ming Shi
Summary: This study aimed to explore the effects of BPF on glucose metabolism and insulin sensitivity. The results showed that BPF treatment altered the expression of adipokines, impaired the insulin signaling pathway, and reduced insulin-stimulated glucose metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Jingjing Shao, Shibo Liu, Xiao Zheng, Jing Chen, Lei Li, Zhimin Zhu
Summary: BBR administration improved glucose metabolism and bone metabolism in DM rats, alleviated high-glucose-inhibited osteogenesis of BMSCs by upregulating ROS-mediated IRS-1 signaling, and promoted implant osseointegration in DM rats.
Review
Biochemistry & Molecular Biology
Maria Teresa Vietri, Giovanna D'Elia, Gemma Caliendo, Marianna Resse, Amelia Casamassimi, Luana Passariello, Luisa Albanese, Michele Cioffi, Anna Maria Molinari
Summary: Genetic factors play a crucial role in the development of prostate cancer, with mutations in mismatch repair and homologous recombination genes being associated with susceptibility. Patients with these mutations may benefit from specific drug therapies. Detecting genetic alterations can help predict treatment responses and optimize treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Thanigaivelan Kanagasabai, Guoliang Li, Tian Huai Shen, Nataliya Gladoun, Mireia Castillo-Martin, Sherly I. Celada, Yingqiu Xie, Lakendria K. Brown, Zaniya A. Mark, Josiah Ochieng, Billy R. Ballard, Carlos Cordon-Cardo, Samuel E. Adunyah, Renjie Jin, Robert J. Matusik, Zhenbang Chen
Summary: The study found that miR-21 promotes the progression of prostate cancer by activating the IRS1/SREBP-1 axis, and targeting the miR-21/SREBP-1 signaling pathway may be a novel strategy for controlling the malignancy of prostate cancer.
Article
Oncology
Dev Karan, Manohar Singh, Seema Dubey, Peter J. Van Veldhuizen, Yogen Saunthararajah
Summary: In this study, the unique role of guadecitabine (gDEC) in activating lysine methyl-transferases (KMTs) and its association with prostate cancer inhibition was described. It was found that gDEC upregulated epigenetic activating enzymes and contributed to the overall change in prostate cancer phenotype and anticancer effect independent of apoptosis. Mechanistically, gDEC increased the methylation of H3K4 in prostate cancer cell lines by depleting DNMT1. This study highlights the therapeutic potential of gDEC in reversing aberrant epigenetic repression and treating prostate cancer.
Article
Cell Biology
Hang Xu, Jiapeng Zhang, Xiaonan Zheng, Ping Tan, Xingyu Xiong, Xianyanling Yi, Yang Yang, Yan Wang, Dazhou Liao, Hong Li, Qiang Wei, Jianzhong Ai, Lu Yang
Summary: Perturbations of the circadian clock, specifically activation of the REV-ERB nuclear receptors, have been found to have antitumor effects on multiple cancers. In this study, the researchers investigated the impact of SR9009, a pharmacological activator of REV-ERB receptors, on prostate cancer (PCa). They discovered that SR9009 specifically killed PCa cells but had no cytotoxic effect on normal prostate cells. SR9009 inhibited colony formation, cell cycle progression, and cell migration, and promoted apoptosis in PCa cells. The researchers also found that SR9009 significantly inhibited the most aggressive and lethal PCa subtype (PCS1) through the FOXM1 pathway blockade. Further analysis identified seven genes involved in the FOXM1 pathway and PCS1, which were all upregulated in PCa tissues and downregulated after SR9009 treatment. Interestingly, knockdown or knockout of REV-ERB receptors did not rescue the anticancer effect of SR9009, indicating that another pathway was involved. The researchers confirmed that SR9009 activated the LXR alpha pathway, and knockdown of LXR alpha resulted in changes in gene expression similar to SR9009 treatment. In vivo studies further validated the effectiveness of SR9009 in inhibiting tumor growth and downregulating FOXM1 expression. Overall, this study suggests that SR9009 can be a potential treatment option for highly aggressive and lethal PCS1 tumors through the mediation of the LXR alpha/FOXM1 pathway independently of REV-ERB receptors.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Kai Wang, Xuliang Wang, Xian Fu, Ji Sun, Liwei Zhao, Huadong He, Yi Fan
Summary: This study found that LCMR1 is highly expressed in CRPC tissues and is accompanied by high concentrations of inflammatory factors. Knocking down LCMR1 inhibits the metastasis and proliferation, and induces apoptosis of CRPC cells. LCMR1 may regulate the conversion from ADPC to CRPC by activating the GR alpha signaling pathway.
Article
Medicine, Research & Experimental
Putcharawipa Maneesai, Banyaphon Jan-o, Anuson Poasakate, Siwayu Rattanakanokchai, Terdthai Tong-Un, Sophida Phuthong, Poungrat Pakdeechote
Summary: Limonin, a natural triterpenoid found in citrus fruit, has shown potential effects in alleviating the symptoms and improving cardiometabolic disorders associated with diet-induced metabolic syndrome in rats. It helps reduce body weight, fasting blood glucose, insulin levels, cholesterol levels, blood pressure, liver fat accumulation, and adipocyte hypertrophy. Limonin also improves cardiac function, decreases angiotensin converting enzyme activity, reduces inflammation and oxidative stress, and restores impaired protein expression in the target tissues of metabolic syndrome.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Dali Tong
Summary: Prostate cancer undergoes genomic alterations and signaling pathway activation during therapy, leading to the development of castration-resistant prostate cancer. These changes involve canonical AR, SPOP/FOXA1 mutations, as well as activation of pathways like PI3K, WNT/beta-catenin, promoting tumor progression.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Endocrinology & Metabolism
Chensheng Le, Xin Hu, Lusha Tong, Xianghua Ye, Junyi Zhang, Jun Yan, Prativa Sherchan, John H. Zhang, Feng Gao, Jiping Tang
Summary: This study investigated the role of LAR in neuroinflammation after intracerebral hemorrhage (ICH) using a mouse model. The results showed that LAR contributed to neuroinflammation after ICH via the RhoA/IRS-1 pathway, and the inhibitor ELP may be a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation after ICH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Minyu Wang, Wanying Huang
Summary: This study found that FOXS1 activates the Hedgehog (Hh) signaling pathway by blocking the ubiquitination of Gli1, thereby promoting the growth and metastasis of prostate cancer cells. High levels of FOXS1 were associated with worse tumor stage and shorter survival in prostate cancer patients.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Fang Yu, Tao Bai
Summary: This study revealed that Sevoflurane enhances macrophage M2 polarization and the metastatic potential of prostate cancer cells, resulting in increased lung metastasis. Mechanistically, Sevoflurane upregulates the expression of IL-6, which subsequently enhances HO-1 expression. In vivo experiments confirmed that Sevoflurane promotes macrophage M2 polarization and lung metastasis through the IL-6/HO-1 pathway. These findings highlight the importance of Sevoflurane in prostate cancer metastasis and suggest that the IL-6/HO-1 pathway could be a potential target for preventing lung metastasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Desiree M. Straign, Claire L. Ihle, Meredith D. Provera, Philip Owens
Summary: Prostate cancer bone metastases are common and often lead to painful skeletal events, with the BMP and TGF beta signaling pathways showing distinct effects in lytic or blastic bone lesions. Inhibiting BMP with DMH1 treatment restricts colonization of cancer cells in bone and preserves bone health. This suggests that profiling bone lesions in metastatic prostate cancer can help identify therapeutic targets to improve treatment outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Rui-ji Liu, Zhi-Peng Xu, Xiang Huang, Bin Xu, Ming Chen
Summary: YY1 is identified as a dysregulated transcription factor that plays a key role in neuroendocrine prostate cancer progression. Androgen deprivation therapy stabilizes YY1 protein, enhancing its transcriptional activity and promoting cellular plasticity through the non-canonical Wnt pathway.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Kelly Coffey
Summary: Prostate cancer is a common cancer in men, and targeting the Hippo pathway for new treatment approaches may help improve the management of this disease.
Article
Public, Environmental & Occupational Health
Marco Piccininni, Jessica L. Rohmann, Maximilian Wechsung, Giancarlo Logroscino, Tobias Kurth
Summary: This article discusses the impact of age and education correction on discrimination performance in cognitive screening tests and quantifies it using a causal framework. The results show that correcting test scores removes meaningful information, leading to a decrease in discrimination performance.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Sabina Davidsson, Anna Messing Eriksson, Ruzan Udumyan, Per Swanholm, Maria Lewin Lundh, Carolina Widing, Christina Lindlof, Jonna Fridfeldt, Sven-Olof Andersson, Katja Fall
Summary: Studies have shown inconsistent results regarding the association between androgen deprivation therapy (ADT) and the risk or severity of SARS-CoV-2 infection in prostate cancer patients. This study found no differences in symptoms or risk of SARS-CoV-2 infection between patients with and without ADT after adjusting for potential confounders.
Review
Economics
Ana Sofia Oliveira Goncalves, Sophia Werdin, Tobias Kurth, Dimitra Panteli
Summary: This review aimed to identify how studies deal with methodological challenges of repeated measurements in mapping algorithms using patient responses to questionnaires. The inconsistent use of methods to account for interdependent observations indicates a need for mapping guidelines and journal updates.
Article
Pediatrics
Stefanie Theuring, Mascha Kern, Franziska Hommes, Marcus A. A. Mall, Joachim Seybold, Frank P. P. Mockenhaupt, Toivo Glatz, Tobias Kurth
Summary: During the COVID-19 pandemic, children and adolescents worldwide have been disproportionately affected in their psychological health and wellbeing. A cohort study in Germany found that anxiety symptoms among school children decreased from June to August 2021, but increased again in September 2021. Factors such as gender, school type, household education and income level, and COVID-19 vaccination were significantly associated with reporting anxiety symptoms.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Jessica L. Rohmann, Rodrigo Huerta-Gutierrez, Heinrich J. Audebert, Tobias Kurth, Marco Piccininni
Summary: This study demonstrates the potential bias in using unadjusted stacked bar graphs to compare functional outcomes after stroke. By using IPT weighting to account for measured confounding, the researchers were able to present more accurate results.
EUROPEAN STROKE JOURNAL
(2023)
Article
Genetics & Heredity
Corinna Grasemann, Jakob Hoppner, Peter Burgard, Michael M. Schundeln, Nora Matar, Gabriele Mueller, Heiko Krude, Reinhard Berner, Min Ae Lee-Kirsch, Fabian Hauck, Kerstin Wainwright, Sylvana Baumgarten, Janet Atinga, Jens J. Bauer, Eva Manka, Julia Korholz, Cordula Kiewert, Andre Heinen, Tanita Kretschmer, Tobias Kurth, Janna Mittnacht, Christoph Schramm, Christoph Klein, Holm Graessner, Olaf Hiort, Ania C. Muntau, Annette Grueters, Georg F. Hoffmann, Daniela Choukair
Summary: The transition process from paediatric/adolescent to adult medical care settings is crucial for the future health of adolescents with chronic diseases, especially in the context of rare diseases. This study presents a patient-focused transition pathway that can be adopted for different rare diseases, aiming to improve patients' health literacy and empower them through individualized training and counselling.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Ayako Hiyoshi, Mikael Rostila, Katja Fall, Scott Montgomery, Alessandra Grotta
Summary: This study examines the changes in smoking, drinking, eating, physical activity, and leisure pursuits in relation to caregiving. The findings suggest that there are differences in behavior changes between co-resident and out-of-home caregiving, as well as variations based on sex, educational attainment, and welfare state typology.
SOCIAL SCIENCE & MEDICINE
(2023)
Letter
Oncology
Qianwei Liu, Krisztina D. Laszlo, Dang Wei, Carsten Obel, Fen Yang, Katja Fall, Unnur Valdimarsdottir, Maria Feychting, Jiong Li, Fang Fang
CANCER COMMUNICATIONS
(2023)
Editorial Material
Urology & Nephrology
Stacey A. Kenfield, Erin L. Van Blarigan, Rebecca E. Graff, Hala T. Borno, Greta Macaire, June M. Chan
EUROPEAN UROLOGY FOCUS
(2023)
Article
Oncology
Hronn Hardardottir, Thor Aspelund, Katja Fall, Erika Brostroem, Baldur B. Sigurdsson, Elizabeth Cook, Heiddis Valdimarsdottir, Fang Fang, Erica K. Sloan, Susan K. Lutgendorf, Christer Jansson, Unnur A. Valdimarsdottir
Summary: Receiving a lung cancer diagnosis is associated with an increase in psychological distress, while elevated catecholamine levels are evident already before lung cancer diagnosis. Patients diagnosed with lung cancer experienced an increase in psychological distress, whereas patients with non-malignant lung pathology showed a decrease in distress before diagnosis.
Article
Clinical Neurology
Marco Piccininni, Ralph Brinks, Jessica L. Rohmann, Tobias Kurth
Summary: This study used modern epidemiological methods to estimate the prevalence of never, active, and inactive migraine. The transition rate from active to inactive migraine increased after age 22.5 for women and 27.5 for men in Germany. The estimated prevalence of inactive migraine at age 60 was 25.7% for women in Germany and 16.5% globally, and 10.4% for men in Germany and 7.1% globally.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Health Care Sciences & Services
Vanessa Voelskow, Claudia Messner, Tobias Kurth, Amelie Busam, Toivo Glatz, Natalie Ebert
Summary: During the COVID-19 pandemic in Germany, telephone hotlines of local health authorities were overwhelmed with information requests. This study evaluated the use of a COVID-19-specific voicebot (CovBot) in these authorities and found that while it provided some relief to staff, it could not fully replace human assistance.
Article
Clinical Neurology
Eugen Schwabauer, Marco Piccininni, Erik Freitag, Martin Ebinger, Frederik Geisler, Peter Harmel, Annegret Hille, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Tobias Kurth, Jessica L. Rohmann, Matthias Endres, Frieder Schlunk, Joachim Weber, Matthias Wendt, Heinrich J. Audebert
Summary: The study found that dispatching Mobile Stroke Units (MSUs) led to a reduction in systolic blood pressure (sBP) and shorter dispatch-to-imaging time compared to conventional ambulance care for patients with acute intracerebral haemorrhage (ICH). However, there was no significant difference in other outcomes, including 7-day mortality and favorable outcome.
EUROPEAN STROKE JOURNAL
(2023)
Meeting Abstract
Oncology
Avery Braun, Janet E. Cowan, June M. Chan, John Neuhaus, Peter Carroll, Matthew R. Cooperberg
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Vivian N. Liu, Erin L. Van Blarigan, Li Zhang, Rebecca E. Graff, Crystal Langlais, Janet E. Cowan, Peter Carroll, June M. Chan, Stacey A. Kenfield
JOURNAL OF CLINICAL ONCOLOGY
(2023)
