Article
Oncology
Mark A. Baxter, Lindsay C. Spender, Shaun Walsh, Susan Bray, Gemma Skinner, Sharon S. King, Peter S. Hall, Matthew J. Seymour, Russell D. Petty
Summary: Gastroesophageal adenocarcinoma (GOA) is a cancer with poor survival, but females have better outcomes. The reason for this is unknown. A study using samples from a clinical trial found no clear link between outcome and oestrogen receptor expression, but observed improved survival with older age and female sex.
Article
Oncology
Yalin Xie, Ning Su, Wei Zhou, An Lei, Xiang Li, Weiwei Li, Zhan Huang, Wenchang Cen, Jinxing Hu
Summary: For EGFR mutant LUAD patients, concurrent PTB can affect the efficacy of EGFR-TKI treatment, especially showing poorer survival outcomes.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Roberto Chalela, Jose Gregorio Gonzalez-Garcia, Karys Khilzi, Victor Curull, Albert Sanchez-Font, Raquel Longaron, Maria Teresa Rodrigo-Calvo, Clara Martin-Ontiyuelo, Joaquim Gea, Beatriz Bellosillo
Summary: Driver mutations in non-tumoral lung cells were detected in a proportion of subjects with ADC, indicating their potential role in carcinogenesis. The presence of these mutations in the absence of coexisting mutations in the primary tumor was confirmed through highly sensitive PCR methods.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Medicine, General & Internal
Qing Ju, Tingping Huang, Yong Zhang, Lei Wu, Jing Geng, Xiaoyan Mu, Tao Yan, Jian Zhang
Summary: Lung cancer is a common cancer worldwide, with specific tyrosine kinase inhibitors of EGFR and the novel systemic immune-inflammation index playing important roles in treatment. SII serves as a key predictor for survival and recurrence in various tumors.
Review
Biochemistry & Molecular Biology
Jose Luis Civico-Ortega, Isabel Gonzalez-Ruiz, Pablo Ramos-Garcia, David Cruz-Granados, Valerie Samayoa-Descamps, Miguel angel Gonzalez-Moles
Summary: The aim of this systematic review and meta-analysis was to assess the clinicopathological and prognostic significance of epidermal growth factor receptor (EGFR) overexpression in patients with oral squamous cell carcinoma (OSCC). A total of 50 primary-level studies (4631 patients) met the inclusion criteria. The findings support that immunohistochemical assessment of EGFR overexpression may serve as a useful prognostic biomarker for OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Yongfei Fan, Yong Zhou, Ming Lou, Zhaojia Gao, Xinwei Li, Kai Yuan
Summary: This study found that SLC6A8 was overexpressed in LUAD and was associated with poor prognosis. SLC6A8 may serve as a biomarker for poor prognosis in LUAD.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Xuan Yi, Linlin Luo, Yanzhen Zhu, Hong Deng, Huitian Liao, Yang Shen, Yan Zheng
Summary: SPP1 plays a critical role in promoting cell migration and invasion in lung adenocarcinoma by upregulating COL11A1 expression.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Jian-Jiang Jin, Ting Zheng, Xiao-Xia Xu, Lei Zheng, Fang -Yuan Li, Xing -Xing Li, Li Zhou
Summary: COL1A2 expression in colorectal adenocarcinoma is associated with prognosis and may serve as a potential therapeutic target.
Article
Multidisciplinary Sciences
Mingrui Shao, Shize Yang, Siyuan Dong
Summary: Through analysis of gene expression datasets, MCM10 was identified as a potential prognostic biomarker for lung adenocarcinoma, with diagnostic and therapeutic value. Overexpression of MCM10 was found to correlate with poor prognosis and larger tumor size.
Article
Oncology
Xin Zou, Yue Zhang, Ning Wang, Jie Shi, Qinghai Li, Wanming Hao, Wenjing Zhu, Wei Han
Summary: In this study, HEG1 was found to be downregulated in lung adenocarcinoma (LUAD) patients and associated with poor prognosis. This suggests that HEG1 may serve as a potential biomarker for diagnosis and prognosis of LUAD.
Article
Oncology
Chengyu Bian, Xinti Sun, Jingjing Huang, Wenhao Zhang, Guang Mu, Ke Wei, Liang Chen, Yang Xia, Jun Wang
Summary: In this study, we found that GT-related lncRNAs have independent prognostic characteristics in LUAD, which can serve as important predictors for predicting patient survival and guiding treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Cong Niu, Wenjia Qiu, Xiangyang Li, Hongqing Li, Ji'an Zhou, Huili Zhu
Summary: Despite surgical resection, a significant number of early-stage lung cancer patients still experience relapse and death. The enzyme transketolase (TKT) has been found to play a critical role in the progression and prognosis of lung adenocarcinoma (LUAD), and might serve as a potential biomarker for predicting recurrence after cancer resection.
Reprint
Pathology
Christopher M. Heaphy, Aatur D. Singhi
Summary: Pancreatic neuroendocrine tumors (PanNETs) are a group of heterogeneous tumors with increasing incidence. The current prognostic systems are not accurate and additional biomarkers, such as DAXX, ATRX, and ALT, are needed to improve patient stratification. This review discusses the clinical utility and testing methods of these biomarkers in PanNETs.
Review
Pathology
Christopher M. Heaphy, Aatur D. Singhi
Summary: Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms with increasing incidence and an ill-defined pathobiology. Additional biomarkers, such as DAXX, ATRX, and ALT, are needed to improve the prognostic stratification of patients diagnosed with a PanNET.
Article
Oncology
Ting Xu, Zhe Zhang, Hongqiang Chen, Ruili Cai, Qian Yang, Qi Liu, Yahan Fan, Wenbin Liu, Chunyan Yao
Summary: The upregulation of CPN2 in lung adenocarcinoma is associated with poor clinical outcome and may serve as an independent prognostic factor. CPN2 is positively correlated with multiple signaling pathways and its knockdown inhibits cell proliferation, clone formation, invasion, and migration in lung adenocarcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rakesh Shiradkar, Ananya Panda, Patrick Leo, Andrew Janowczyk, Xavier Farre, Nafiseh Janaki, Lin Li, Shivani Pahwa, Amr Mahran, Christina Buzzy, Ping Fu, Robin Elliott, Gregory MacLennan, Lee Ponsky, Vikas Gulani, Anant Madabhushi
Summary: Significant differences were observed in TCRs and T1 and T2 MRF between PCa, prostatitis, and normal PZ. T1 and T2 MRF showed correlations with epithelium and stroma of PCa, with T1 MRF in opposite directions between PCa and prostatitis. T2 MRF was positively correlated with lumen of PCa and prostatitis.
EUROPEAN RADIOLOGY
(2021)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Rakesh Shiradkar, Ananya Panda, Patrick Leo, Andrew Janowczyk, Xavier Farre, Nafiseh Janaki, Lin Li, Shivani Pahwa, Amr Mahran, Christina Buzzy, Pingfu Fu, Robin Elliott, Gregory MacLennan, Lee Ponsky, Vikas Gulani, Anant Madabhushi
Summary: The original version of this article, published on September 2, 2020, unfortunately contained a mistake.
EUROPEAN RADIOLOGY
(2021)
Letter
Cell Biology
Brett Delahunt, Lars Egevad, Hemamali Samaratunga, John R. Srigley, Liang Cheng, David Clouston, Bungo Furusato, James Kench, Katia R. M. Leite, Gregory T. MacLennan, Holger Moch, Chin-Chen Pan, Jae Ro, Toyonori Tsuzuki, Theodorus van der Kwast, Thomas Wheeler, John W. Yaxley
Article
Oncology
William R. Grubb, Lee Ponsky, Simon S. Lo, Michael Kharouta, Bryan Traughber, Kate Sandstrom, Gregory T. MacLennan, Eswar Shankar, Sanjay Gupta, Mitchell Machtay, Rodney J. Ellis
Summary: The study demonstrated the feasibility of dose escalation to 60 Gy in 3 fractions for localized renal cell carcinoma patients without dose-limiting toxicities. Post-SBRT biopsies showed favorable local control rates, but the interpretation of biopsy results remains uncertain.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Clinical Neurology
S. Mathew, Darrell D. Davidson, J. Tejada, M. Martinez, J. Kovoor
Summary: This study evaluated the safety and feasibility of CAS in symptomatic carotid webs. CAS was found to be a feasible and safe treatment for patients with ischemic embolic strokes caused by carotid web, with no recurrent strokes or TIAs occurring during the follow-up period.
INTERVENTIONAL NEURORADIOLOGY
(2021)
Article
Oncology
Ariel A. Nelson, Robert J. Cronk, Emily A. Lemke, Aniko Szabo, Ali R. Khaki, Leonidas N. Diamantopoulos, Petros Grivas, Behtash Ghazi Nezami, Gregory T. MacLennan, Tian Zhang, Christopher J. Hoimes
Summary: The study found that patients with mUC and eBM have poorer outcomes, may benefit less from anti-PD-1/PD-L1 therapy, and require novel therapeutic interventions. Dedicated clinical trials, biomarker validation, and consensus on reporting non-measurable disease are necessary.
Article
Oncology
Laura Bukavina, Kirtishri Mishra, Amr Mahran, Austin Fernstrum, III Al Ray, Sarah Markt, Fredrick Schumacher, Britt Conroy, Robert Abouassaly, Gregory MacLennan, Garrett Smith, Elizabeth Ferry, Daniel Wong, Yair Lotan, Hemant Chaparala, David Sharp, Kareem Alazem, Alireza Moinzadeh, Brittany Adamic, Gregory Zagaja, Puneet Kang, Holly Lawry, Benjamin Lee, Adam Calaway, Lee Ponsky
Summary: The study investigated the outcomes of performing multiple robotic-assisted surgeries on the same operating day, specifically focusing on robotic-assisted laparoscopic prostatectomy. Results showed that sequential surgeries did not significantly impact outcomes such as positive surgical margin rate, lymph node yield, or operative time. Factors such as disease-specific characteristics and institutional experience were found to be more closely associated with the risk of positive surgical margins.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Elisha Fredman, Bryan Traughber, Michael Kharouta, Tarun Podder, Simon Lo, Lee Ponsky, Gregory MacLennan, Raj Paspulati, Bradley Ellis, Mitchell Machtay, Rodney Ellis
Summary: Through rigorous imaging and pathology concordance, our pilot trials of f-SBRT planning revealed that confirmatory biopsies often identified additional disease, suggesting caution in partial-gland therapy. For truly focal disease, f-SBRT provided excellent dosimetry, minimal toxicity, and encouraging biochemical response among patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Yu Wang, Eric C. Abenojar, Jing Wang, Al C. Leon, Sidhartha Tavri, Xinning Wang, Ramamurthy Gopalakrishnan, Ethan Walker, Gregory T. MacLennan, Anoja Giles, Gregory J. Czarnota, James P. Basilion, Agata A. Exner
Summary: In this study, a prostate cancer model was successfully established in immunosuppressed rabbits, providing a clinically relevant intermediate step for assessing preclinical interventions. The minimally invasive ultrasound-guided tumor cell injection proved to be a better method compared to laparotomy, allowing for shorter recovery time for the rabbits.
Article
Oncology
Shiv Verma, Eswar Shankar, Spencer Lin, Vaibhav Singh, E. Ricky Chan, Shufen Cao, Pingfu Fu, Gregory T. MacLennan, Lee E. Ponsky, Sanjay Gupta
Summary: This study identified a 3-gene signature panel with prognostic value in bladder cancer, including CDKN2A, CDC20, CTSV, FOXM1, MAGEA6, KRT23, and S100A9. These genes were confirmed to have strong prognostic values in bladder cancer and were validated through qRT-PCR in various human bladder cancer cells representing stage-specific disease progression. Additionally, ULCAN, human protein atlas, and The Cancer Genome Atlas datasets were used to confirm the predictive value of these genes in bladder cancer progression.
Article
Urology & Nephrology
Ilaha Isali, Ahmad Osama Khalifa, Subba Shankar, Stanley Dannemiller, Walter Horne, Michelle Evancho-Chapman, Phillip McClellan, Gregory T. MacLennan, Ozan Akkus, Adonis Hijaz
Summary: This study evaluates the use of sheep as a potential model for preclinical evaluation of urethral slings. The anatomical measurements and histological tissue integration in sheep show similar results to humans, suggesting the suitability of this model for biomaterial response assessment.
UROLOGIA INTERNATIONALIS
(2023)
Article
Engineering, Biomedical
Ahmad O. Khalifa, Ilaha Isali, Hakan Celik, Michael Mastran, Phillip McClellan, Callan Gillespie, Subba Shankar, Gregory T. MacLennan, James M. Anderson, Fredrick R. Schumacher, Ozan Akkus, Adonis K. Hijaz
Summary: This study evaluated the in vivo response to collagen slings implanted in an ovine model and found that collagen slings demonstrated biocompatibility and tissue ingrowth ability.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Urology & Nephrology
Laura Bukavina, Megan Prunty, Kirtishri Mishra, Helen Sun, David Sheyn, Britt Conroy, Amr Mahran, Gregory MacLennan, Fredrick Schumacher, Lee Ponsky, Sarah Markt
Summary: This study utilized the Ohio state cancer registry to investigate the impact of socioeconomic and demographic factors on bladder cancer outcomes. The results showed that female gender, self-reported black race, and living in neighborhoods with higher poverty levels were associated with worse bladder cancer-specific survival. The findings suggest a need to address these disparities and risk factors to improve survival rates among affected populations.
Article
Pathology
Svitlana Y. Bachurska, Petar A. Antonov, Ivan Y. Dechev, Antonio Lopez-Beltran
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2020)
Review
Pharmacology & Pharmacy
Gaetano Aurilio, Matteo Santoni, Alessia Cimadamore, Francesco Massari, Marina Scarpelli, Antonio Lopez-Beltran, Liang Cheng, Nicola Battelli, Franco Nole, Rodolfo Montironi
EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT
(2020)