Article
Medicine, General & Internal
Costanza Chiapponi, Hakan Alakus, Matthias Schmidt, Michael Faust, Christiane J. Bruns, Reinhard Buettner, Marie-Lisa Eich, Anne M. Schultheis
Summary: The documentation of lymphatic vessel invasion in pathology reports of papillary thyroid cancer (PTC) is inconsistent, but the correlation between L1 diagnosis and lymph node metastasis (LNM) suggests its relevance for clinical decision-making.
FRONTIERS IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zengjie Wu, Qing Lin, Hongming Song, Jingjing Chen, Guanqun Wang, Guangming Fu, Chunxiao Cui, Xiaohui Su, Lili Li, Tiantian Bian
Summary: This study developed a scoring model based on preoperative MRI images to predict lymphatic vessel invasion (LVI) in breast cancer. The model showed satisfactory efficacy in noninvasively predicting LVI status, providing valuable information for personalized therapeutic planning.
ACADEMIC RADIOLOGY
(2023)
Article
Medicine, General & Internal
Jia-Mei Chen, Bo Luo, Ru Ma, Xi-Xi Luo, Yong-Shun Chen, Yan Li
Summary: Metastasis via lymphatic or blood vessels is the leading cause of death for breast cancer. However, the research progress for tumor lymphangiogenesis has lagged behind that for angiogenesis due to the lack of specific markers. With the discovery of lymphatic endothelial cell (LEC) markers, it has been shown that LEC plays an active role in various processes related to lymphatic formation, tumor growth, invasion, and antitumor immunity.
Article
Medicine, Research & Experimental
Jian Chen, Fan Zhang, Mengmeng Hua, Xiaobin Song, Shaohua Liu, Zuoqing Dong
Summary: This study demonstrated a significant association between intratumoral lymphatic vessel density (ILVD) and increased lymphatic metastasis, tumor recurrence, and reduced disease-specific survival in patients with oral squamous cell carcinoma. ILVD could be considered as an indicator for predicting the prognosis of OSCC.
Review
Biochemistry & Molecular Biology
Ljuba C. Ponomarev, Jakub Ksiazkiewicz, Michael W. Staring, Aernout Luttun, An Zwijsen
Summary: Bone morphogenetic proteins (BMPs) play a key role in vascular signaling, contributing to the morphological, functional, and molecular heterogeneity among endothelial cells in different vessel types. The BMP pathway is finely-tuned and its signaling output in the vessel wall critically depends on cellular context, including flow hemodynamics, interaction with other vascular signaling cascades, and the interaction of endothelial cells with peri-endothelial cells and the surrounding matrix.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Young Yun Jung, Jeong-Hyeon Ko, Jae-Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Gautam Sethi, Kwang Seok Ahn
Summary: Hypercholesterolemia is closely linked with increased cancer incidence and mortality, and LDL-induced STAT3 activation may have a profound impact on the proliferation and survival of prostate and pancreatic tumor cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Dawid Sigorski, Jacek Gulczynski, Aleksandra Sejda, Wojciech Rogowski, Ewa Izycka-Swieszewska
Summary: The study revealed differences in neural parameters between prostate cancer and benign prostate, with a heterogeneous neural network in PCa. Higher neural density was observed in the surrounding and invasive front of the tumor. NPY expression, neuroendocrine differentiation, and ERG status were found to be related to ND and PNI. The findings provide evidence for autocrine and paracrine interactions in the neural microenvironment of prostate cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Joshua S. T. Hooks, Fabrice C. Bernard, Ricardo Cruz-Acuna, Zhanna Nepiyushchikh, Yarelis Gonzalez-Vargas, Andres J. Garcia, J. Brandon Dixon
Summary: The lymphatic vasculature plays a crucial role in the body's circulation system, and studying its growth mechanisms and developing related biomaterial strategies is of great importance. Utilizing an engineered hydrogel material, the sprouting and transplantation of lymphatic vessels can be facilitated, providing a promising platform for further research on lymphangiogenesis.
Article
Biochemistry & Molecular Biology
Bok-Soon Lee, Jeon Yeob Jang, Chorong Seo, Chul-Ho Kim
Summary: Inhibition of CXCL5-CXCR2 signaling pathway can suppress invasion and metastasis of HNSCC cells. Intervening with the signaling pathway between tumor cells and lymphatic endothelial cells may provide a new therapeutic strategy for the clinical management of HNSCC.
Review
Immunology
Veronique Angeli, Hwee Ying Lim
Summary: The research on lymphatic biology has revealed the important roles of lymphatic vessels in maintaining human health. It is not surprising that dysfunctions in lymphatic vessels are associated with various human diseases beyond lymphedema. Understanding the mechanical forces that affect lymphatic vessel functions may lead to new therapeutic options.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Cell Biology
Lulin Cheng, Qingliu He, Bing Liu, Liang Chen, Fang Lv, Xuexiang Li, Yunxue Li, Chunyu Liu, Yarong Song, Yifei Xing
Summary: Recent research has shown that ferroptosis, the iron-dependent accumulation of lipid peroxides that leads to cell death, suppresses cancer metastasis. In this study, the essential role of serum/glucocorticoid regulated kinase 2 (SGK2) in promoting prostate cancer metastasis by inhibiting ferroptosis was identified. SGK2 knockdown inhibited the metastatic capacity of prostate cancer cells, while SGK2 overexpression inhibited ferroptosis and facilitated prostate cancer metastasis by phosphorylating FOXO1. These findings reveal a novel role of SGK2 in regulating ferroptosis and driving prostate cancer metastasis.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Chika Kuroda, Kumiko Ajima, Katsuya Ueda, Atsushi Sobajima, Kazushige Yoshida, Takayuki Kamanaka, Jun Sasaki, Haruka Ishida, Hisao Haniu, Masanori Okamoto, Kaoru Aoki, Hiroyuki Kato, Naoto Saito
Summary: Nanomaterials have great potential for biological applications, but their clinical use is limited by the lack of established safety assessment methods, especially regarding their interactions with lymphatic vessels. Development of new systems to study nanomaterial biokinetics in lymphatic vessels is crucial for advancing the biological applications of nanomaterials.
Article
Oncology
Shimpei Yamashita, Satoshi Muraoka, Takahito Wakamiya, Kazuro Kikkawa, Yasuo Kohjimoto, Isao Hara
Summary: The impact of lymphatic invasion on biochemical recurrence (BCR) in high-risk prostate cancer patients who underwent robot-assisted radical prostatectomy (RARP) and extended lymph node dissection (eLND) was assessed in a prospective cohort study. Lymphatic invasion was found to be an independent significant predictor of BCR, and its evaluation could be useful in predicting BCR in patients undergoing RARP and eLND for high-risk PC.
Article
Biology
Kazuaki Maruyama, Sachiko Miyagawa-Tomita, Yuka Haneda, Mayuko Kida, Fumio Matsuzaki, Kyoko Imanaka-Yoshida, Hiroki Kurihara
Summary: Lymphatic vessels play a crucial role in maintaining tissue homeostasis and immune responses in vertebrates. Recent studies have identified two major sources of lymphatic endothelial cells (LECs): venous sprouting (lymphangiogenesis) and de novo production from non-venous origins (lymphvasculogenesis). This research using genetic lineage tracing in mice reveals that a subset of cardiopharyngeal mesoderm cells, known as Isl1-expressing cells, give rise to LECs in the craniofacial and cardiac regions. These findings enhance our understanding of lymphatic vessel development and may provide insights into the pathogenesis of lymphatic malformations.