Review
Biochemistry & Molecular Biology
Brian V. Hong, Jingyuan Zheng, Angela M. Zivkovic
Summary: This review discusses the role of HDL during childhood, pregnancy, and in the elderly, as well as the potential adverse health outcomes associated with disturbances in HDL and knowledge gaps in the role of HDL across these life stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marie Cecilie Paasche Roland, Kristin Godang, Pal Aukrust, Tore Henriksen, Tove Lekva
Summary: This study examined the differences in lipoproteins, CETP activity, and HDL-C between women giving birth to large-for-gestational-age and small-for-gestational-age infants. It was found that women with small-for-gestational-age infants had higher triglycerides in large VLDL and lipids/cholesterol/cholesteryl esters in small HDL. Additionally, women with higher HDL-C had lower levels of CETP expression in the placenta.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Saba Soltani, Motahareh Boozari, Arrigo F. G. Cicero, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: HDL plays a crucial role in cardiovascular diseases, while phytochemicals have the potential to enhance cholesterol efflux. Current research mostly focuses on preclinical studies, indicating a need for more clinical research to develop novel clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Matteo Pedrelli, Paolo Parini, Jonas Kindberg, Jon M. Arnemo, Ingemar Bjorkhem, Ulrika Aasa, Maria Westerstahl, Anna Walentinsson, Chiara Pavanello, Marta Turri, Laura Calabresi, Katariina Oorni, German Camejo, Ole Frobert, Eva Hurt-Camejo
Summary: Plasma cholesterol and triglyceride levels in hibernating brown bears are double those of healthy humans, yet bears do not show signs of early atherosclerosis. Analysis revealed higher levels of certain lipids in bear VLDL and LDL during winter, along with differences in lipid composition. Additionally, bear plasma demonstrated higher cholesterol efflux capacity and lower LDL binding to arterial proteoglycans compared to humans.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Hematology
Minghao Kou, Ning Ding, Shoshana H. Ballew, Maya J. Salameh, Seth S. Martin, Elizabeth Selvin, Gerardo Heiss, Christie M. Ballantyne, Kunihiro Matsushita, Ron C. Hoogeveen
Summary: Triglyceride-related and HDL-related lipids were independently associated with incident PAD, indicating implications for preventive strategies. Principal component analysis identified three components related to PAD risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Wynn G. Hunter, Alexander G. Smith, Rui C. Pinto, Suzanne Saldanha, Anamika Gangwar, Mandana Pahlavani, Sneha Deodhar, John Wilkins, Ambarish Pandey, David Herrington, Philip Greenland, Ioanna Tzoulaki, Anand Rohatgi
Summary: This study investigated the associations between metabolites and cholesterol efflux capacity (CEC) and found independent associations between CEC and the largest-sized particle subclasses of VLDL and HDL, as well as their constituent apolipoproteins and lipids. However, metabolite profiles had poor accuracy in predicting CEC, and race was found to be the most important factor influencing CEC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Teresa Padro, Anallely Lopez-Yerena, Antonio Perez, Gemma Vilahur, Lina Badimon
Summary: High-density lipoproteins (HDLs) are complex particles that have multiple cardiovascular protective properties. Diet, specifically supplementation with ?3 and phytosterols, has been shown to improve the lipid profile of HDL. This study found that ?3 supplementation had greater effects on HDL lipidome compared to phytosterols, particularly in cholesteryl esters (CEs). Furthermore, the HDL lipidome was found to be sex-dependent. Overall, this study highlights the importance of diet and sex in modulating the HDL lipid profile.
Article
Public, Environmental & Occupational Health
Sang-Wook Yi, Se-Jun Park, Jee-Jeon Yi, Heechoul Ohrr, Hyeongsu Kim
Summary: The study found U-curve associations between HDL-C levels and mortality, regardless of sex or age. Younger adults had a lower optimal range and a stronger positive association with mortality in the high HDL-C range compared to older adults. Even moderately high HDL-C levels may not necessarily indicate good health, especially in young adults.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Medicine, Research & Experimental
Maria Bove, Stefania Schiavone, Paolo Tucci, Lisa Pia Agosti, Stefania Dimonte, Maria Adelaide Palmieri, Vladyslav Sikora, Maria Matteo, Luigia Trabace, Maria Grazia Morgese
Summary: Low intake of n-3 polyunsaturated fatty acids (PUFA) during adolescence is associated with increased risk of depressive-like symptoms in both males and females. In this study, we found that adolescent rats fed with a low n-3 PUFA diet showed anxiety-like behavior, but immune activation was different between males and females.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Anna E. Engell, Henrik L. Jorgensen, Bent S. Lind, Anton Pottegard, Christen L. Andersen, John S. Andersen, Margit Kriegbaum, Mia K. Grand, Lise Bathum
Summary: Lipid levels in blood have decreased significantly in the general population due to the use of statins. This trend was observed in primary health care patients who were not using statins from 2001 to 2018, with substantial decreases in total cholesterol and low-density lipoprotein cholesterol levels, especially in the elderly population.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Pharmacology & Pharmacy
Jelena Vekic, Aleksandra Zeljkovic, Aleksandra Stefanovic, Natasa Bogavac-Stanojevic, Ioannis Ilias, Jose Silva-Nunes, Anca Pantea Stoian, Andrej Janez, Manfredi Rizzo
Summary: There is compelling evidence linking increased levels of low-density lipoprotein cholesterol (LDL-C) to the development of atherosclerotic cardiovascular disease (CVD). However, recent data shows that the majority of patients in Europe are unable to achieve their recommended LDL-C targets. To address this issue, a new approach to lipid-lowering, involving more intensive and earlier intervention, has been proposed for high-risk patients. Additionally, novel lipid biomarkers, such as small dense LDL particles (sdLDL), should be considered as potential therapeutic targets.
Article
Biology
Yafang Wang, Yang Liu, Yan Wang, Yidong Wu, Zhixuan Chen, Feng Wang, Xiaoling Wan, Fenghua Wang, Xiaodong Sun
Summary: Disordered immune responses and cholesterol metabolism are implicated in age-related macular degeneration (AMD), the leading cause of blindness in elderly individuals. In this study, researchers investigated the role and mechanism of SULT2B1 and STS enzymes in AMD. They found that SULT2B1 promoted M2 macrophage activation and cholesterol efflux, while STS inhibited M2 polarization through LXR-ABCA1/G1 signaling to protect against choroidal neovascularization.
LIFE SCIENCE ALLIANCE
(2023)
Article
Nutrition & Dietetics
Christine Bobin-Dubigeon, Hassan Nazih, Mikael Croyal, Jean-Marie Bard
Summary: According to the findings from clinical and laboratory data, researchers discovered a correlation between EPA and DHA carried by non-HDL lipoproteins and breast cancer severity, suggesting a potential protective effect on the proliferation of breast cancer in HR- tumors.
Article
Food Science & Technology
Ruslan Sultanov, Ekaterina Ermolenko, Tatiana Poleschuk, Yulia Denisenko, Sergey Kasyanov
Summary: The study demonstrated that dietary supplementation with AGs and n-3 PUFAs can improve hematological parameters in elderly rats, including increasing red blood cell and hemoglobin count, decreasing platelet count, and stimulating the immune system. Additionally, the supplementation increased the concentration of plasmalogens and docosahexaenoic acid in the liver, indicating potential benefits for overall health and immune function during aging.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Nutrition & Dietetics
Alyann Otrante, Amal Trigui, Roua Walha, Hicham Berrougui, Tamas Fulop, Abdelouahed Khalil
Summary: EVOO intake improves cholesterol efflux capacity of HDL in elderly subjects by modulating the distribution of HDL subclasses, leading to enhanced anti-atherogenic activity of HDL.
