Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 82, Issue 4-6, Pages 227-230Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2010.02.017
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Polyunsaturated fatty acids of nutritional value may affect cell functions after their release from cell lipid storage sites, especially phospholipids, and specific oxygenation by cyclooxygenases, lipoxygenases and cytochrome P(450). The end-products, namely prostanoids, leukotrienes, and mono-, di- and tri-hydroxy derivatives exhibit a variety of biological effects, especially on vascular cells, leukocytes and platelets. This paper reviews some results obtained with blood platelets as target cells, showing that various lipoxygenase end-products, mainly mono- and di-hydroxy derivatives, are inhibitors (IC(50) in mu M range) of arachidonic acid-induced aggregation either at the cycloxygenase or thromboxane receptor site level. (C) 2010 Elsevier Ltd. All rights reserved.
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