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A cautionary note on the correct structure assignment of phytoprostanes and the emergence of a new prostane ring system

Journal

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2009.10.005

Keywords

Phytoprostanes; Isoprostanes; Structure; Biological activity

Funding

  1. Academy of Sciences of the Czech Republic [Z4 055 0506]
  2. University Montpellier I [BQR-2008]

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Considerable confusion exists about the correct structural representation of phytoprostanes (PhytoP). Improper use of the different nomenclature systems leads to incorrect structure assignment of PhytoP, which results in wrong synthetic approaches to these molecules and may lead to wrong rationalization of biological activity. A new prostane ring system was found, which is proposed to be termed L(1)-PhytoP or L(2)-IsoP, respectively. (C) 2010 Elsevier Ltd. All rights reserved.

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