Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 81, Issue 1, Pages 89-96Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2009.04.005
Keywords
DyAdd; Adult; Dyslexia; ADHD; Fatty acids
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In project DyAdd, we compared the fatty acid (FA) profiles of serum phospholipids in adults with attention deficit hyperactivity disorder (ADHD) (n = 26), dyslexia (n = 36), their comorbid combination (n = 9), and healthy controls (n = 36). FA proportions were analyzed in a 2 x 2 design with Bonferroni corrected post hoc comparisons. A questionnaire was used to assess dietary fat quality and use of Supplements. Results showed that ADHD and dyslexia were not associated with total saturated FAs, monounsaturated FAs, OF n-3 polyunsaturated FAs (PUFAs). However, those with ADHD had elevated Proportions of total n-6 PUFAs (including gamma-linolenic and adrenic acids) as compared to those without ADHD. Dyslexia was related to a higher proportion of monounsaturated nervonic acid and a higher ratio of n-6/n-3 PUFAs. Among females none of the associations were significant. However in males, all the original associations observed in all subjects remained and ADHD was associated with elevated nervonic acid and n-6/n-3 PUFA ratio like dyslexia. Controlling for poorly diagnosed reading difficulties, education, dietary fat quality, or use of FA supplements did not generally remove the originally observed associations. (C) 2009 Elsevier Ltd. All rights reserved.
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