Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 81, Issue 5-6, Pages 331-339Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2009.09.008
Keywords
Obesity; Insulin; Rats; n-3 fatty acids
Funding
- Flax Council of Canada (CT)
- Canada-Manitoba Agri-Food Research and Development Initiative (CT, PZ)
- Natural Sciences and Engineering Council of Canada (NSERC)
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The objective was to examine the effect of polyunsaturated fatty acid type (plant vs fish oil-derived n-3, compared to n-6 fatty acids in the presence of constant proportions of saturated, monounsaturated and polyunsaturated fatty acids) on obesity, insulin resistance and tissue fatty acid composition in genetically obese rats. Six-week-old fa/fa and lean Zucker rats were fed with a 10% (w/w) mixed fat diet containing predominantly flax-seed, menhaden or safflower oils for 9 weeks. There was no effect of dietary lipid on obesity, oral glucose tolerance (except t=60 min insulin), pancreatic function or molecular markers related to insulin, glucose and lipid metabolism, despite increased n-3 fatty acids in muscle and adipose tissue. The menhaden oil diet reduced fasting serum free fatty acids in both fa/fa and lean rats. These data suggest that n-3 composition does not alter obesity and insulin resistance in the fa/fa Zucker rat model when dietary lipid classes are balanced. (C) 2009 Elsevier Ltd. All rights reserved.
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