Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 104, Issue -, Pages 74-83Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2012.11.002
Keywords
Cyclooxygenases; T helper cells; Prostanoids; PGE2
Categories
Funding
- Intramural NIH HHS [Z01 ES025043-09] Funding Source: Medline
Ask authors/readers for more resources
Cyclooxygenases and their metabolites are important regulators of inflammatory responses and play critical roles in regulating the differentiation of T helper cell subsets in inflammatory diseases. In this review, we highlight new information on regulation of T helper cell subsets by cyclooxygenases and their metabolites. Prostanoids influence cytokine production by both antigen presenting cells and T cells to regulate the differentiation of naive CD4(+) T cells to Th1, Th2 and Th17 cell phenotypes. Cyclooxygenases and PGE(2) generally exacerbate Th2 and Th17 phenotypes, while suppressing Th1 differentiation. Thus, cycloxygenases may play a critical role in diseases that involve immune cell dysfunction. Targeting of cyclooxygenases and their eicosanoid products may represent a new approach for treatment of inflammatory diseases, tumors and autoimmune disorders. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available