4.8 Article

Palladium-Catalyzed Carbonylation of Indoles for Synthesis of Indol-3-yl Aryl Ketones

Journal

ACS CATALYSIS
Volume 5, Issue 2, Pages 1210-1213

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/cs5019106

Keywords

palladium-catalyzed; carbonylation; indoles; arylboronic acids; indol-3-yl aryl ketones

Funding

  1. National Natural Science Foundation of China [21472147, 21272183]
  2. Rising Stars of Shanxi Province [2012KJXX-26]

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A novel palladium-catalyzed carbonylation of indoles with CO and aromatic boronic acids for the synthesis of indol-3-yl aryl ketones was developed. The reaction tolerates a wide range of functional groups and gives a variety of valuable indol-3-yl aryl ketones in high yields under mild conditions.

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