Article
Surgery
Macey L. Levan, Allan B. Massie, Chad Trahan, Jonathan Hewlett, Tyler Strout, Samantha B. Klitenic, Karen B. Vanterpool, Dorry L. Segev, Bradley L. Adams, Patricia Niles
Summary: There are significant variations in deceased organ donation rates in the United States, with the rates of approach and authorization of families playing a crucial role. First-person authorization, ethnicity, and gender are associated with donation rates. Increasing the proportion of families approached may lead to higher donation rates.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Oncology
David Hui, Yvonne Heung, Eduardo Bruera
Summary: Timely palliative care is personalized care based on patients' needs, delivered at the optimal time and setting. It involves systematic identification of high supportive care needs patients and referral to specialist palliative care based on standardized criteria. Implementation requires visionary leadership, commitment of oncology teams, robust palliative care clinic, customized referral criteria, and integrated electronic health records.
Article
Pharmacology & Pharmacy
Donghua Zheng, Genglong Liu, Li Chen, Wenfeng Xie, Jiaqi Sun, Siqi Wang, Qiang Tai
Summary: The administration of terlipressin can significantly improve hemodynamics in hypotensive brain-dead patients, while maintaining renal function stability and improvement without affecting liver function.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Ethics
Antoine Baumann, Nathalie Thilly, Liliane Joseph, Frederique Claudot
Summary: Relatives play a significant role in post-mortem organ donation decisions, but their decision-making may be affected by grief. The lack of ethical reflection support emphasizes the importance of involving specialized professionals for assistance.
Article
Nursing
Luciana Nabinger Menna Barreto, Eder Marques Cabral, Marina Raffin Buffon, Juliana Elenice Pereira Mauro, Lisiane Pruinelli, Miriam de Abreu Almeida
Summary: This study analyzed the diagnostic accuracy of Impaired physiological balance syndrome in potential brain-dead organ donors, finding that specific indicators can assist in accurate diagnosis and intervention inference.
CLINICAL NURSING RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Fatemeh Hadavandsiri, Davood Khalili, Alireza Mahdavi, Mehdi Afkar, Afshin Ostovar, Seyed-Saeed Hashemi-Nazari, Somayeh Derakhshan
Summary: This study aimed to investigate the compliance rate and related factors among individuals participating in the IraPEN program for cardiovascular disease prevention in Iran. The study found that the overall compliance rate was very low and high-risk individuals showed lower compliance. Cardiovascular risk factors were associated with lower compliance.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Surgery
A. K. Israni, D. Zaun, J. D. Rosendale, C. Schaffhausen, W. McKinney, J. J. Snyder
Summary: In 2019, there was an increase in both the number of deceased organ donors and organ transplants, which may be linked to the rising death rates of young people due to the opioid epidemic. The data indicates an opportunity to increase transplant numbers by reducing organ discards.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Damiano Patrono, Davide Cussa, Veronica Sciannameo, Elena Montanari, Rebecca Panconesi, Paola Berchialla, Mirella Lepore, Alessandro Gambella, Giorgia Rizza, Giorgia Catalano, Stefano Mirabella, Francesco Tandoi, Francesco Lupo, Roberto Balagna, Mauro Salizzoni, Renato Romagnoli
Summary: Dual hypothermic oxygenated machine perfusion (D-HOPE) improves preservation and outcomes in liver transplantation, especially when utilizing donors after neurological determination of death (DBD). D-HOPE reduces early graft failure, complications, and improves survival for both patients and grafts, including elderly donors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Pierre Marsolais, Gabrielle Larouche, Anne-Marie Lagace, Virginie Williams, Karim Serri, Francis Bernard, Philippe Rico, Anne Julie Frenette, David Williamson, Martin Albert, Emmanuel Charbonney
Summary: The study aims to investigate the perception of feasibility of potential organ donors among external evaluators. The findings suggest that there is significant variability in the evaluation of potential donors, particularly in the final outcome of organs not procured.
TRANSPLANT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
David R. Spielberg, Ernestina Melicoff, Jeffrey S. Heinle, Kathleen Hosek, George B. Mallory
Summary: Despite progress in clinical transplantation, a shortage of suitable donor organs remains a constraint. Lungs are the most likely organs to be deemed unsuitable for transplantation. Optimizing donor management can increase the availability of organs for transplantation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Mengmeng Ji, Amanda J. Vinson, Su-Hsin Chang, Massini Merzkani, Krista L. Lentine, Yasar Caliskan, Kristin Progar, Nicole Nesselhauf, Casey Dubrawka, Tarek Alhamad
Summary: This study evaluated kidney use and transplant outcomes from deceased donors with active or resolved COVID-19, showing a decreasing likelihood of nonuse over time and no worse outcomes within 2 years post-transplant.
Article
Surgery
Matthew J. Bock, Gabrielle R. Vaughn, Peter Chau, Jennifer A. Berumen, John J. Nigro, Elizabeth G. Ingulli
Summary: The study suggests that COVID-19 infection in deceased solid organ transplant donors does not affect recipient survival. However, there is a lack of information regarding the selection of COVID-19-positive donors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Martin J. Dutch, Cameron J. Patrick, Peter A. Boan, Jonathan C. Knott, Helen I. Opdam
Summary: Internationally, designating a patient as an increased viral risk organ donor is associated with lower utilization rates. The actual prevalence of blood-borne viruses among potential organ donors in Australia and the effectiveness of risk stratification questionnaires remain unknown. A retrospective review was conducted on patients who underwent evaluation for organ donation between 2014 and 2020. The prevalence rates of HIV, active HBV, and active HCV in 3650 potential organ donors were 0.16%, 0.9%, and 2.2% respectively. A subset of 3633 patients underwent behavioral risk profiling. Increased risk behaviors reported by next-of-kin were associated with a higher prevalence of HCV but not HIV or HBV. HIV and HBV infections were also found in potential donors without a history of disclosed increased risk behaviors. Donors had a higher prevalence of HCV, similar rates of HBV and HIV compared to the general community. Behavioral transmission risks were not effective predictors for HIV and HBV. Post-transplant recipient screening may be a more effective tool in mitigating unexpected viral transmission risks.
TRANSPLANT INTERNATIONAL
(2022)
Article
Surgery
Akila Chandrasekar, Richard Lomas, Jacinto Sanchez-Ibanez, Mar Lomero, Arlinke Bokhorst, Margarida Ivo Da Silva, Esteve Trias, Alicia Perez Blanco, Beatriz Dominguez-Gil, Marta Lopez-Fraga
Summary: Physical examination of organ and tissue donors is essential but lacking standardized guidelines in the EU. Surveys conducted among health authorities and professionals in European countries revealed significant variations in regulatory requirements and professional practices of physical examination for donors. There is a need for agreed best practice guidelines in this area.
TRANSPLANT INTERNATIONAL
(2023)
Article
Neurosciences
Siddharth Chavali, Girija P. Rath, Deep Sengupta, Surya K. Dube
Summary: Formal brainstem reflex testing is crucial for identifying and evaluating patients meeting clinical criteria for brainstem death, with early identification being essential for organ donation. However, during the COVID-19 pandemic, organ transplantation from brainstem dead donors has declined significantly due to various reasons, including perceived risks of virus transmission and lack of awareness regarding donor workup.
