Review
Cell Biology
Sonali Nashine
Summary: This article discusses the contribution of aging to ocular diseases such as AMD, and introduces potential therapeutic candidates for AMD along with their known mechanisms of cytoprotection.
Article
Biochemistry & Molecular Biology
Hanan ElShelmani, Ian Brennan, David J. Kelly, David Keegan
Summary: This study discovered differentially regulated miRNAs in the serum of AMD patients, with eight miRNAs showing higher expression in dry AMD patients compared to wet AMD patients and healthy controls. These miRNAs may serve as diagnostic biomarkers for AMD and potential treatment targets in the future. Detection of significant serum miRNA biomarkers in AMD patients could provide an easy screening tool for at-risk populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Karolina Urbanska, Piotr Witold Stepien, Katarzyna Natalia Nowakowska, Martyna Stefaniak, Natalia Osial, Tomasz Choragiewicz, Mario Damiano Toro, Katarzyna Nowomiejska, Robert Rejdak
Summary: This review provides an overview of the influence of miRNA on the pathogenesis, diagnosis, and treatment of age-related macular degeneration (AMD). miRNAs may serve as potential molecular biomarkers for AMD and targeting specific miRNA abnormalities could offer hope for preventing irreversible vision loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Jiang-Hui Wang, Raymond C. B. Wong, Guei-Sheung Liu
Summary: In this study, the transcriptomic characteristics and cellular landscape of aging retinas in control individuals and AMD patients were analyzed. Aging genes associated with innate immune response and inflammation in the neural retina were identified. Deconvolution analysis revealed an increased proportion of M2 macrophages with both age and AMD severity, while the proportion of Muller glia only increased with age. Several genes, particularly C1s and MR1, were strongly correlated with the proportion of Muller glia and with age and AMD severity.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Review
Neurosciences
Genea Edwards, Caroline G. Olson, Carlyn P. Euritt, Peter Koulen
Summary: The eye is sensitive to oxidative stress, and vitamin E plays a crucial role in protecting against degenerative diseases. Vitamin E has diverse antioxidant activity and can promote neuroprotective effects through several signaling pathways. Further research is needed to fully understand its clinical implications.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Reem H. ElSheikh, Muhammad Z. Chauhan, Ahmed B. Sallam
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population, with neovascular AMD (nAMD) being the main contributor to visual loss. Currently approved anti-VEGF agents have shown favorable prognosis for nAMD but come with a substantial financial burden for patients and the healthcare system due to their high cost and the need for repeated treatments and visits. Emerging therapies aim to prolong treatment intervals and introduce new modalities for better results.
Article
Medicine, General & Internal
Saurav Mallik, Fran Grodstein, David A. Bennett, Demetrios G. Vavvas, Bernardo Lemos
Summary: This study identified regression-based biological age clocks for the retina and explored their applications in Age-Related Macular Degeneration (AMD). The clocks showed good separation among AMD samples of different severity scores and demonstrated consistent age reprograming features in cultured cells. Additionally, potential targets mechanistically linked to AMD and aging were discovered. These clocks have potential applications in monitoring AMD and in vitro screens.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Shenouda Girgis, Lawrence R. Lee
Summary: Age-related macular degeneration is a global disease with a significant social impact, and the treatment of neovascular AMD has been revolutionized by the advent of anti-VEGF therapy. Currently, investigations are being conducted for possible therapeutic options for dry AMD. Various treatments, including complement pathway inhibitors, visual cycle modulators, antioxidative therapy, gene therapy, and stem cell therapy, are undergoing clinical trials. Two intravitreal anti-complement factors have shown promising results in reducing the growth of geographic atrophy.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Biology
Thomas H. Julian, Johnathan Cooper-Knock, Stuart MacGregor, Hui Guo, Tariq Aslam, Eleanor Sanderson, Graeme C. M. Black, Panagiotis Sergouniotis, Lois E. H. Smith
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness, and this study aims to identify causal factors and potential therapeutic targets for AMD through a phenome-wide Mendelian randomisation (MR) study. The results of this study support several putative causal factors for AMD and provide avenues for future translational research.
Review
Biochemistry & Molecular Biology
Yeon-Kyoung Cho, Dae-Hun Park, In-Chul Jeon
Summary: Age-related macular degeneration (AMD) is central vision loss associated with aging and has various risk factors. Treatment options include device-based therapy, anti-inflammatory drugs, anti-VEGF drugs, and natural products. Natural products used as AMD drugs, mainly administered orally, can be combined with other treatments for potential therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Chemical
Yeon-Kyoung Cho, Seung-Min Lee, Yeong-Ji Kang, Yeong-Mo Kang, In-Chul Jeon, Dae-Hun Park
Summary: Age-related macular degeneration (AMD) is a visual disorder that affects the elderly, and the number of cases may increase due to the aging population. Current therapies for AMD include device-based treatments, anti-inflammatory drugs, anti-vascular endothelial growth factor treatments, and natural product treatments. Although AMD is incurable, its symptoms can be suppressed. Some natural products have shown potential in preventing early AMD by inhibiting cell death and activating anti-apoptotic pathways.
Article
Biochemistry & Molecular Biology
Filomena Palmieri, Saad Younis, Walid Raslan, Lorenzo Fabozzi
Summary: This study reports the clinical and multimodal imaging findings of patients with neovascular age-related macular degeneration who developed bacillary layer detachment. The research was conducted at the Western Eye Hospital in London, UK. The results show that bacillary layer detachment can be detected in patients with neovascular age-related macular degeneration, which is not commonly described in the literature for this disease.
Article
Medicine, General & Internal
Agnieszka Budnik, Marta Sabasinska-Grzes, Magdalena Michnowska-Kobylinska, Lukasz Lisowski, Malgorzata Szpakowicz, Magdalena Lapinska, Anna Szpakowicz, Marcin Kondraciuk, Karol Adam Kaminski, Joanna Konopinska
Summary: Research has shown that inflammatory factors play an important role in the development of age-related macular degeneration (AMD) and glucose disturbances (GD), with C1qTNF1 identified as a key mediator in the integration of lipid metabolism and inflammatory responses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Audrey Voisin, Afsaneh Gaillard, Anais Balbous, Nicolas Leveziel
Summary: This study found that retinal pigment epithelial (RPE) cells from patients with age-related macular degeneration (AMD) exhibit altered phagocytic activity. The researchers also identified genes related to the mTOR/PI3K-AKT/MEK-ERK pathway that are involved in phagocytosis. These findings indicate a typical disease phenotype in RPE cells from AMD patients.
Article
Ophthalmology
Leo C. Hahn, Mary J. van Schooneveld, Nieneke L. Wesseling, Ralph J. Florijn, Jacoline B. ten Brink, Birgit I. Lissenberg-Witte, Ine Strubbe, Magda A. Meester-Smoor, Alberta A. Thiadens, Roselie M. Diederen, Caroline van Cauwenbergh, Julie de Zaeytijd, Sophie Walraedt, Elfride de Baere, Caroline C. W. Klaver, Jeannette Ossewaarde-van Norel, L. Ingeborgh van den Born, Carel B. Hoyng, Maria M. van Genderen, Paul A. Sieving, Bart P. Leroy, Arthur A. Bergen, Camiel J. F. Boon
Summary: This study found large variabilities in the phenotype and natural course of X-linked retinoschisis (XLRS), with most patients showing a slow deterioration starting in the second decade of life. The integrity of the ellipsoid zone (EZ) and the photoreceptor outer segment (PROS) length on spectral-domain optical coherence tomography (SD OCT) may be important in selecting optimal candidates for treatment and as potential structural endpoints in future therapeutic studies. No clear genotype-phenotype correlation was found.
Review
Ophthalmology
Richard F. Spaide, Chui Ming Gemmy Cheung, Hidetaka Matsumoto, Shoji Kishi, Camiel J. F. Boon, Elon H. C. van Dijk, Martine Mauget-Faysse, Francine Behar-Cohen, M. Elizabeth Hartnett, Sobha Sivaprasad, Tomohiro Iida, David M. Brown, Jay Chhablani, Peter M. Maloca
Summary: Central serous chorioretinopathy (CSC) is characterized by fluid leakage at the level of the retinal pigment epithelium, leading to macular detachment. Recent evaluations have shown that eyes with CSC have similar choroidal vascular abnormalities as eyes following occlusion of the vortex veins or carotid cavernous sinus fistulas. Abnormal venous outflow from the choroid appears to be a key factor in the pathophysiology of CSC.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Ophthalmology
Mariantonia Ferrara, Vito Romano, Claudio Iovino, Mustafa R. Kadhim, Elon H. C. van Dijk, Camiel J. F. Boon, Piergiacomo Grassi, Sibel Demirel, Cristian Cartes, Mario R. Romano
Summary: This study aimed to identify the preferences of audience and faculty in digital education sessions in ophthalmology. The survey results showed that most respondents preferred digital education sessions to last 30-60 minutes without a break, to be held in the evening time-slot of a weekday. The availability of webinars and recorded surgical videos/clinical cases, associated with live discussion, were considered the most important opportunities in digital educational channels.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Tin Yan Alvin Liu, Carlthan Ling, Leo Hahn, Craig K. Jones, Camiel J. F. Boon, Mandeep S. Singh
Summary: This study demonstrates the use of cSLO imaging and deep learning to estimate visual acuity in retinitis pigmentosa (RP) patients, showing promising performance in predicting visual impairment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Elon H. C. van Dijk, Helena M. A. Feenstra, Jakob Bjerager, Jakob Grauslund, Camiel J. F. Boon, Yousif Subhi
Summary: The treatment of chronic central serous chorioretinopathy (cCSC) is controversial. This study reviewed the short-term efficacy of different cCSC treatments and found that half-dose/half-fluence photodynamic therapy (PDT), conventional laser, and selective retina therapy (SRT) provide significant improvement compared to no treatment. Half-dose/half-fluence PDT is the only viable treatment option for cCSC patients.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Helena M. A. Feenstra, Elon H. C. van Dijk, Thomas J. van Rijssen, Roula Tsonaka, Roselie M. H. Diederen, Carel B. Hoyng, Reinier O. Schlingemann, Camiel J. F. Boon
Summary: This study compares the anatomic and functional efficacy and safety of primary treatment with half-dose photodynamic therapy (PDT) or oral eplerenone, or crossover treatment in chronic central serous chorioretinopathy patients. The results showed that most patients treated with half-dose PDT achieved complete resolution of subretinal fluid (SRF) after 12 months, and patients who received primary half-dose PDT had better long-term visual acuity compared to those who delayed PDT treatment due to initial eplerenone therapy with persistent SRF.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Marc J. Sirks, Helena M. A. Feenstra, Florentine R. de Vries, Greet Dijkman, Camiel J. F. Boon, Elon H. C. van Dijk
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Helena M. A. Feenstra, Roselie M. H. Diederen, Martine J. C. M. Lamme, Roula Tsonaka, Sascha Fauser, Suzanne Yzer, Thomas van Rijssen, Theodora Gkika, Susan M. Downes, Reinier O. Schlingemann, Carel B. Hoyng, Elon H. C. van Dijk, Camiel J. F. Boon
Summary: A retrospective study analyzed the data from two prospective randomized controlled trials to evaluate the risk of foveal atrophy and the likelihood of improvement in structure and function with half-dose photodynamic therapy in chronic central serous chorioretinopathy. The results showed significant improvement in optical coherence tomography and fundus autofluorescence after treatment, with no development of foveal atrophy in any of the patients.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Francesco Romano, Mariano Cozzi, Davide Monteduro, Marta Oldani, Camiel J. F. Boon, Giovanni Staurenghi, Anna Paola Salvetti
Summary: This study describes the imaging characteristics and topographic expansion of retinal pigment epithelium (RPE) and outer retinal atrophy in extensive macular atrophy with pseudodrusen-like appearance. The findings suggest that the primary alterations occur at the outer segment-RPE interface, and the superior sector is the most vulnerable. Visual acuity decline is significantly associated with subfoveal atrophy and fibrosis. A three-stage disease classification is proposed.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Danial Mohabati, Camiel J. F. Boon, Carel B. B. Hoyng, Konstantine Purtskhvanidze, Johann Roider, Elon H. C. van Dijk
Summary: This study aims to assess the correlation between findings on fundus autofluorescence (FAF) and fluorescein angiography (FA) in chronic central serous chorioretinopathy (cCSC) patients. The discrepancy between FAF and FA was measured and compared, and a relationship between the discrepancy and disease characteristics was found. The study suggests that baseline FAF and follow-up duration can predict long-term changes in cCSC.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Meeting Abstract
Ophthalmology
Jeroen Adrianus Antonius Hendrikus Pas, Patty P. A. Dhooge, Philipp T. Moeller, Katarina Stingl, Camiel J. F. Boon, Andrew J. Lotery, Maurizio Battaglia Parodi, Philipp Herrmann, Wolfgang Klein, Mario G. Fsadni, Thomas H. Wheeler-Schilling, Frank G. Holz, Carel C. B. Hoyng, Steffen Schmitz-Valckenberg
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Bart Peter Leroy, Katarina Stingl, Isabelle S. Audo, Camiel J. F. Boon, Fernanda Belga O. Porto, Michel Michaelides, Helene Dollfus, L. Ingeborgh Van den Born, Lyubomyr M. Lytvynchuk, Francesca Simonelli, Juliana M. F. Sallum, Robert K. Koenekoop, Elise Heon, Stephen R. Russell, Michael Schwartz, Aniz Girach
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Leo Hahn, Mary J. van Schooneveld, Ralph J. Florijn, Jacoline B. ten Brink, Ine Strubbe, Magda M. Meester-Smoor, Alberta A. H. J. Thiadens, Roselie M. H. Diederen, Caroline C. W. Klaver, Carel C. B. Hoyng, Mies M. van Genderen, Bart P. Leroy, Arthur A. Bergen, Camiel J. F. Boon
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
J. Brinks, E. H. C. van Dijk, R. Tsonaka, O. C. Meijer, C. J. F. Boon
ACTA OPHTHALMOLOGICA
(2022)
Meeting Abstract
Ophthalmology
H. M. A. Feenstra, J. Hensman, Th. Gkika, R. M. H. Diederen, R. O. Schlingemann, S. M. Downes, E. H. C. van Dijk, C. J. F. Boon
ACTA OPHTHALMOLOGICA
(2022)
