Review
Biochemistry & Molecular Biology
Angela Armento, Marius Ueffing, Simon J. Clark
Summary: Age-related macular degeneration (AMD) is a complex disease with genetic, aging, and lifestyle factors all playing a role in its onset and progression. Therapeutic attempts targeting the complement system have not been successful, highlighting the complexity of AMD beyond genetic factors.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Niloofar Piri, Henry J. Kaplan
Summary: AMD is a progressive degenerative disease that severely affects central vision in people over age 50, impacting their ability to read, write, drive, and recognize faces. The disease is complex and multifactorial, involving age, genetics, and environmental factors. The role of complement system in the development of AMD is reviewed. Understanding the pathophysiology of AMD and its risk factors is crucial for drug discovery.
Article
Ophthalmology
Michael D. Osterman, Yeunjoo E. Song, Muneeswar Nittala, SriniVas R. Sadda, William K. Scott, Dwight Stambolian, Margaret A. Pericak-Vance, Jonathan L. Haines
Summary: This study identified potential novel genetic risk loci for AMD in a midwestern Amish study population and determined a clear link between the genetic risk of AMD and drusen. Further study may improve understanding of the biological risk factors underlying drusen development.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Medicine, General & Internal
Amy C. Cohn, Zhichao Wu, Andrew I. Jobling, Erica L. Fletcher, Robyn H. Guymer
Summary: This article summarizes the potential of lasers in slowing the progression of AMD and key findings from clinical trials, while also highlighting the importance of advances in multimodal imaging and functional testing, as well as ongoing investigation of key pathological mechanisms in further exploring the utility of nanosecond and other subthreshold short pulse lasers in AMD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Young Gun Park, Yong Soo Park, In-Beom Kim
Summary: Age-related macular degeneration (AMD) is a complex disease characterized by neovascularization or geographic atrophy. The complement system plays a crucial role in AMD and has become a therapeutic target. Further research is needed to fully understand the mechanism of complement disease propagation in AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Fabian Kananen, Timo Strandberg, Sirpa Loukovaara, Ilkka Immonen
Summary: The study found that high systemic total cholesterol in early middle age may be associated with the initial development of age-related macular degeneration, particularly in patients who later develop large drusen. Lipid values measured in 2011 showed no associations after correction for other factors.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Kai Lyn Goh, Fred K. Chen, Chandrakumar Balaratnasingam, Carla J. Abbott, Lauren A. B. Hodgson, Robyn H. Guymer, Zhichao Wu
Summary: In a cohort of patients with intermediate age-related macular degeneration (AMD), the presence of cuticular drusen was not associated with an increased risk of developing late AMD over a three-year period or with a difference in the rate of visual sensitivity decline.
Article
Medicine, Research & Experimental
Xuan Cao, Jaron Castillo Sanchez, Aumreetam Dinabandhu, Chuanyu Guo, Tapan P. Patel, Zhiyong Yang, Ming-Wen Hu, Lijun Chen, Yuefan Wang, Danyal Malik, Kathleen Jee, Yassine J. Daoud, James T. Handa, Hui Zhang, Jiang Qian, Silvia Montaner, Akrit Sodhi
Summary: This study investigated the relationship between protein expression in aqueous fluid and the response of patients with nvAMD to anti-VEGF therapy. The study found that increased expression of ApoB100 in treated patients correlated with a decreased need for frequent injections. This suggests that aqueous biomarkers, such as ApoB100, may help identify nvAMD patients who do not require or benefit from long-term anti-VEGF therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Ophthalmology
Shenouda Girgis, Lawrence R. Lee
Summary: Age-related macular degeneration is a global disease with a significant social impact, and the treatment of neovascular AMD has been revolutionized by the advent of anti-VEGF therapy. Currently, investigations are being conducted for possible therapeutic options for dry AMD. Various treatments, including complement pathway inhibitors, visual cycle modulators, antioxidative therapy, gene therapy, and stem cell therapy, are undergoing clinical trials. Two intravitreal anti-complement factors have shown promising results in reducing the growth of geographic atrophy.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Zhichao Wu, Erica L. Fletcher, Himeesh Kumar, Ursula Greferath, Robyn H. Guymer
Summary: Reticular pseudodrusen are distinct lesions in the subretinal space that have been increasingly recognized in association with age-related macular degeneration. Understanding their pathogenesis is crucial for understanding the processes driving vision loss in AMD.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yanhui Deng, Lifeng Qiao, Mingyan Du, Chao Qu, Ling Wan, Jie Li, Lulin Huang
Summary: Age-related macular degeneration (AMD) is a complex eye disorder that leads to incurable blindness in the elderly, with wet and dry forms classified as the advanced stages. Genetic factors, lipid metabolism, oxidative stress, and aging all play a role in the development of AMD, with current treatment focusing on anti-VEGF therapy for wet AMD. New AMD drugs and iPSC-derived RPE cell therapy show promise in improving AMD treatment in the near future.
Review
Biochemistry & Molecular Biology
Ruth M. Galindo-Camacho, Cristina Blanco-Llamero, Raquel da Ana, Mayra A. Fuertes, Francisco J. Senorans, Amelia M. Silva, Maria L. Garcia, Eliana B. Souto
Summary: This article reviews the challenges in the treatment of age-related macular degeneration (AMD), innovative nanoformulations, 3D bioprinting, and techniques for monitoring progress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shruti Chandra, Manjot K. Grewal, Sarega Gurudas, Rajan Sondh, Alan Bird, Glen Jeffery, Victor Chong, Sobha Sivaprasad
Summary: The qAF8 levels in patients with non-neovascular AMD were found to be significantly lower compared to age-matched controls, indicating a early and sustained loss of function of the retinal pigment epithelium in AMD.
Review
Biochemistry & Molecular Biology
Prem N. Patel, Parth A. Patel, Matthew R. Land, Ibrahim Bakerkhatib-Taha, Harris Ahmed, Veeral Sheth
Summary: Age-related macular degeneration (AMD) is a common cause of vision loss in elderly individuals. The pathophysiology of dry AMD is associated with key proteins in the complement cascade, providing potential therapeutic targets. Early intervention may prevent disease progression.
Article
Health Care Sciences & Services
Arun Govindaiah, Abdul Baten, R. Theodore Smith, Siva Balasubramanian, Alauddin Bhuiyan
Summary: This study compared the performance of retinal fundus images and genetic-information-based machine learning models in predicting late AMD, with the findings indicating that the model based on retinal image and socio-demographic parameters outperformed the genetic and socio-demographic parameters-based model.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Ophthalmology
Xuan-thanh-an Nguyen, Mays Talib, Mary J. van Schooneveld, J. A. N. Wijnholds, Maria M. van Genderen, Nicoline E. Schalij-delfos, Caroline C. W. Klaver, Herman E. Talsma, Marta Fiocco, Ralph J. Florijn, Jacoline B. ten Brink, Frans P. M. Cremers, Magda A. Meester-smoor, L. Ingeborgh van den Born, Carel B. Hoyng, Alberta A. H. J. Thiadens, Arthur A. Bergen, Camiel J. F. Boon
Summary: This study aimed to investigate the natural disease course of retinal dystrophies associated with CRB1 and identify clinical end points for future trials. Results showed that over 2 years, BCVA and V4e isopter seeing retinal areas remained relatively stable in the entire cohort, but individual patients showed signs of clinical progression. Microperimetry revealed a significant decrease in retinal sensitivity during follow-up.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Thomas J. van Rijssen, Elon H. C. van Dijk, Roula Tsonaka, Helena M. A. Feenstra, Greet Dijkman, Petrus J. H. Peters, Roselie M. H. Diederen, Carel B. Hoyng, Reinier O. Schlingemann, Camiel J. F. Boon
Summary: This study compared the efficacy and safety of half-dose photodynamic therapy and eplerenone therapy for treating chronic central serous chorioretinopathy. The results showed that half-dose PDT was superior to eplerenone treatment in terms of short-term safety and efficacy outcomes.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Mariantonia Ferrara, Vito Romano, Claudio Iovino, Mustafa R. Kadhim, Elon H. C. van Dijk, Camiel J. F. Boon, Piergiacomo Grassi, Sibel Demirel, Cristian Cartes, Mario R. Romano
Summary: This study aimed to identify the preferences of audience and faculty in digital education sessions in ophthalmology. The survey results showed that most respondents preferred digital education sessions to last 30-60 minutes without a break, to be held in the evening time-slot of a weekday. The availability of webinars and recorded surgical videos/clinical cases, associated with live discussion, were considered the most important opportunities in digital educational channels.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Tin Yan Alvin Liu, Carlthan Ling, Leo Hahn, Craig K. Jones, Camiel J. F. Boon, Mandeep S. Singh
Summary: This study demonstrates the use of cSLO imaging and deep learning to estimate visual acuity in retinitis pigmentosa (RP) patients, showing promising performance in predicting visual impairment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Elon H. C. van Dijk, Helena M. A. Feenstra, Jakob Bjerager, Jakob Grauslund, Camiel J. F. Boon, Yousif Subhi
Summary: The treatment of chronic central serous chorioretinopathy (cCSC) is controversial. This study reviewed the short-term efficacy of different cCSC treatments and found that half-dose/half-fluence photodynamic therapy (PDT), conventional laser, and selective retina therapy (SRT) provide significant improvement compared to no treatment. Half-dose/half-fluence PDT is the only viable treatment option for cCSC patients.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Helena M. A. Feenstra, Elon H. C. van Dijk, Thomas J. van Rijssen, Roula Tsonaka, Roselie M. H. Diederen, Carel B. Hoyng, Reinier O. Schlingemann, Camiel J. F. Boon
Summary: This study compares the anatomic and functional efficacy and safety of primary treatment with half-dose photodynamic therapy (PDT) or oral eplerenone, or crossover treatment in chronic central serous chorioretinopathy patients. The results showed that most patients treated with half-dose PDT achieved complete resolution of subretinal fluid (SRF) after 12 months, and patients who received primary half-dose PDT had better long-term visual acuity compared to those who delayed PDT treatment due to initial eplerenone therapy with persistent SRF.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Paula Scholz, Lebriz Altay, Vasilena Sitnilska, Elon H. C. van Dijk, Alberto M. Pereira, Femke M. van Haalen, Isha Akhtar, Camiel J. F. Boon, Sascha Fauser
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Letter
Ophthalmology
Marc J. Sirks, Helena M. A. Feenstra, Florentine R. de Vries, Greet Dijkman, Camiel J. F. Boon, Elon H. C. van Dijk
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Helena M. A. Feenstra, Roselie M. H. Diederen, Martine J. C. M. Lamme, Roula Tsonaka, Sascha Fauser, Suzanne Yzer, Thomas van Rijssen, Theodora Gkika, Susan M. Downes, Reinier O. Schlingemann, Carel B. Hoyng, Elon H. C. van Dijk, Camiel J. F. Boon
Summary: A retrospective study analyzed the data from two prospective randomized controlled trials to evaluate the risk of foveal atrophy and the likelihood of improvement in structure and function with half-dose photodynamic therapy in chronic central serous chorioretinopathy. The results showed significant improvement in optical coherence tomography and fundus autofluorescence after treatment, with no development of foveal atrophy in any of the patients.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Francesco Romano, Mariano Cozzi, Davide Monteduro, Marta Oldani, Camiel J. F. Boon, Giovanni Staurenghi, Anna Paola Salvetti
Summary: This study describes the imaging characteristics and topographic expansion of retinal pigment epithelium (RPE) and outer retinal atrophy in extensive macular atrophy with pseudodrusen-like appearance. The findings suggest that the primary alterations occur at the outer segment-RPE interface, and the superior sector is the most vulnerable. Visual acuity decline is significantly associated with subfoveal atrophy and fibrosis. A three-stage disease classification is proposed.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Danial Mohabati, Camiel J. F. Boon, Carel B. B. Hoyng, Konstantine Purtskhvanidze, Johann Roider, Elon H. C. van Dijk
Summary: This study aims to assess the correlation between findings on fundus autofluorescence (FAF) and fluorescein angiography (FA) in chronic central serous chorioretinopathy (cCSC) patients. The discrepancy between FAF and FA was measured and compared, and a relationship between the discrepancy and disease characteristics was found. The study suggests that baseline FAF and follow-up duration can predict long-term changes in cCSC.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Helena M. A. Feenstra, Elon H. C. van Dijk, Thomas J. van Rijssen, Roula Tsonaka, Roselie M. H. Diederen, Reinier O. Schlingemann, Carel B. Hoyng, Camiel J. F. Boon
Summary: This study compared the efficacy and safety of crossover treatment between half-dose photodynamic therapy (PDT) and eplerenone treatment in patients with chronic central serous chorioretinopathy (cCSC). The results showed that half-dose PDT was more effective in resolving subretinal fluid (SRF) and improving foveal sensitivity compared to eplerenone treatment after the failure of primary treatment.
OPHTHALMOLOGY RETINA
(2022)
Article
Ophthalmology
Leo C. Hahn, Michalis Georgiou, Hind Almushattat, Mary J. van Schooneveld, Emanuel R. de Carvalho, Nieneke L. Wesseling, Jacoline B. ten Brink, Ralph J. Florijn, Birgit Lissenberg-Witte, Ine Strubbe, Caroline van Cauwenbergh, Julie de Zaeytijd, Sophie Walraedt, Elfride de Baere, Rajarshi Mukherjee, Martin McKibbin, Magda A. Meester-Smoor, Alberta A. H. J. Thiadens, Saoud Al-Khuzaei, Engin Akyol, Andrew J. Lotery, Maria M. van Genderen, Jeannette Ossewaarde-van Norel, L. Ingeborgh van den Born, Carel B. Hoyng, Caroline C. W. Klaver, Susan M. Downes, Arthur A. Bergen, Bart P. Leroy, Michel Michaelides, Camiel J. F. Boon
Summary: This study describes the clinical characteristics of Leber congenital amaurosis and cone-rod dystrophy associated with the GUCY2D gene. The study found that Leber congenital amaurosis presents in infancy, while vision loss is progressive and becomes severe during mid-to-late adulthood. The study also identifies potential therapeutic endpoints and optimal patient selection.
OPHTHALMOLOGY RETINA
(2022)
Meeting Abstract
Ophthalmology
Th. J. van Rijssen, H. M. A. Feenstra, E. H. C. van Dijk, R. Tsonaka, R. M. H. Diederen, C. B. Hoyng, R. O. Schlingemann, C. J. F. Boon
ACTA OPHTHALMOLOGICA
(2022)
Meeting Abstract
Ophthalmology
L. Moekotte, X. T. Nguyen, C. J. F. Boon, L. I. Van den Born, J. H. de Boer, J. J. W. Kuiper, M. M. Van Genderen
ACTA OPHTHALMOLOGICA
(2022)
