Article
Psychology, Multidisciplinary
Renee J. Thompson, Daphne Y. Liu, Ella Sudit, Matt Boden
Summary: Individuals with current major depressive disorder (MDD) or in remission exhibit low levels of negative and positive emotion differentiation, indicating that diminished emotion differentiation may be a stable characteristic of depressive disorders and a potential target for future prevention efforts.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Chengwen Liu, Emily L. Belleau, Daifeng Dong, Xiaoqiang Sun, Ge Xiong, Diego A. Pizzagalli, Randy P. Auerbach, Xiang Wang, Shuqiao Yao
Summary: This study investigated dynamic functional connectivity alterations in unmedicated individuals with current or past major depressive disorder (MDD) using co-activation pattern analyses. The results showed that individuals with current MDD had increased dominance of state 1 (default mode network) and decreased dominance of state 4 (frontal-parietal network), while individuals with past MDD had increased entries of state 4. Both MDD groups showed increased FPN-to-DMN transition frequency and a reduction in state 3 (visual attention, somatosensory, limbic networks) compared to healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Weiliang Yang, Yuting Wang, Wen Qin, Meijuan Li, Huan Mao, Chi Zhou, Xueying Liu, Jie Li
Summary: This study investigated the changes in temporal properties of dynamic functional network connectivity (dFNC) in first-episode, drug-naive patients with major depressive disorder (MDD). The results showed that these changes in temporal properties could serve as potential biomarkers for MDD, with good diagnostic performance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Yang Yang, Qian Cui, Fengmei Lu, Yajing Pang, Yuyan Chen, Qin Tang, Di Li, Ting Lei, Zongling He, Shan Hu, Jiaxin Deng, Huafu Chen
Summary: The study revealed abnormal functional connectivity patterns of DMN subsystems in patients with bipolar disorder during major depressive episodes, and these abnormalities were associated with high levels of pessimism, highlighting the importance of pathological mechanisms in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Ashish K. Sahib, Joana R. Loureiro, Megha Vasavada, Cole Anderson, Antoni Kubicki, Benjamin Wade, Shantanu H. Joshi, Roger P. Woods, Eliza Congdon, Randall Espinoza, Katherine L. Narr
Summary: This study found that subanesthetic ketamine infusion therapy can modify the functional connectome in patients with major depressive disorder (MDD), making it closer to the pattern seen in healthy controls. After treatment, there was a significant decrease in functional connectivity between the cerebellum and the salience network (SN). Additionally, patients who responded to treatment showed increased functional connectivity between the cerebellum and the striatum before treatment, which decreased after treatment.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Wanyi Cao, Haiyan Liao, Sainan Cai, Wanrong Peng, Zhaoxia Liu, Kaili Zheng, Jinyu Liu, Mingtian Zhong, Changlian Tan, Jinyao Yi
Summary: Abnormal connectivity between the right inferior parietal lobule and the right dorsolateral prefrontal cortex was found in MDD patients during 2-back task. Dynamic causal modeling analysis revealed increased forward modulation connectivity from the right IPL to the right dlPFC in MDD patients during 2-back task, compared to healthy controls.
HUMAN BRAIN MAPPING
(2021)
Article
Psychiatry
Lei Yang, Chaoyang Jin, Shouliang Qi, Yueyang Teng, Chen Li, Yudong Yao, Xiuhang Ruan, Xinhua Wei
Summary: This study used rs-fMRI to analyze the FC between PPtha and other brain regions in SD and MDD patients. The findings revealed altered FC in SD and MDD patients, providing insights into the potential pathophysiological mechanisms of these disorders.
Article
Clinical Neurology
Zhuoliang Hou, Wenhao Jiang, Fan Li, Xiaoyun Liu, Zhenghua Hou, Yingying Yin, Haisan Zhang, Hongxing Zhang, Chunming Xie, Zhijun Zhang, Youyong Kong, Yonggui Yuan
Summary: This study discovered differences in individual functional connectivity variations between patients with major depressive disorder (MDD) and healthy individuals, and genetic risk may affect the clinical manifestations of depression through brain function heterogeneity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Caroline B. B. C. M. Heuschen, Roel J. T. Mocking, Jasper B. Zantvoord, Caroline A. Figueroa, Aart H. Schene, Damiaan A. J. P. Denys, Henricus G. Ruhe, Claudi L. H. Bockting, Anja Lok
Summary: This study demonstrates that self-reported suicidal symptoms persist during remission in rrMDD and predict recurrence, independent of residual symptoms. Monitoring both suicidal and depressive symptomatology during remission in rrMDD, preferably using self-reported questionnaires, is recommended for future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Behavioral Sciences
P. M. Briley, L. Webster, C. Boutry, W. J. Cottam, D. P. Auer, P. F. Liddle, R. Morriss
Summary: This systematic review explores the differences in resting-state brain connectivity associated with comorbid anxiety in individuals with MDD. The findings suggest that dysconnectivity between the amygdala and other brain networks, as well as abnormalities in default mode network connectivity, may play a role in the co-occurrence of anxiety and MDD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Danielle A. Goldman, Anjali Sankar, Alexandra Rich, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
Summary: This study aimed to identify functional connectivity differences between depressions of bipolar disorder (BD-Dep) and depressions of major depressive disorder (MDD-Dep). The results showed that there were significant differences in functional connectivity patterns between these two groups, suggesting the potential for early diagnosis and treatment strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Yajing Pang, Qiang Wei, Shanshan Zhao, Nan Li, Zhihui Li, Fengmei Lu, Jianyue Pang, Rui Zhang, Kai Wang, Congying Chu, Yanghua Tian, Jiaojian Wang
Summary: This study investigates the longitudinal effects of electroconvulsive therapy (ECT) on resting-state functional connectivity (FC) in patients with major depressive disorder (MDD). The findings suggest that the changes in FC within the default mode network (DMN) and between DMN and central executive network (CEN) may be critical for effective antidepressant treatment and can also serve as neuromarkers for predicting treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Shreyas Harita, Davide Momi, Frank Mazza, John D. Griffiths
Summary: Studying the functional connectivity between TMS targets reveals that differences in brain morphology and function may contribute to the high variability in TMS treatment outcomes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Yanzhuo Song, Jingyu Yang, Miao Chang, Yange Wei, Zhiyang Yin, Yue Zhu, Yuning Zhou, Yifang Zhou, Xiaowei Jiang, Feng Wu, Lingtao Kong, Ke Xu, Fei Wang, Yanqing Tang
Summary: Schizophrenia, bipolar disorder, and major depressive disorder have common neuroimaging characteristics. This study found different alterations in hippocampal subregions among these disorders, providing evidence for the different functions of these subregions in psychiatric pathology.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Noa Tsujii, Wakako Mikawa, Toru Adachi, Soichiro Sakanaka, Osamu Shirakawa
Summary: Patients with remitted major depressive disorder (rMDD) tend to rely on avoidant and emotion-oriented coping strategies, with lower scores in task-oriented coping. Abnormalities in the neural hemodynamic responses of the prefrontal cortex may be associated with coping strategies and vulnerability to MDD recurrence.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Dong Daifeng, Li Chuting, Ming Qingsen, Zhong Xue, Zhang Xiaocui, Sun Xiaoqiang, Jiang Yali, Gao Yidian, Wang Xiang, Yao Shuqiao
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Psychology, Developmental
Yali Jiang, Qingsen Ming, Yidian Gao, Daifeng Dong, Xiaoqiang Sun, Xiaocui Zhang, Weijun Situ, Shuqiao Yao, Hengyi Rao
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2020)
Article
Clinical Neurology
Ge Xiong, Daifeng Dong, Chang Cheng, Yali Jiang, Xiaoqiang Sun, Jiayue He, Chuting Li, Yidian Gao, Xue Zhong, Haofei Zhao, Xiang Wang, Shuqiao Yao
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Clinical Neurology
Daifeng Dong, Chuting Li, Xue Zhong, Yidian Gao, Chang Cheng, Xiaoqiang Sun, Ge Xiong, Qingsen Ming, Xiaocui Zhang, Xiang Wang, Shuqiao Yao
JOURNAL OF AFFECTIVE DISORDERS
(2020)
Article
Psychology, Biological
Xiaoqiang Sun, Chuting Li, Xue Zhong, Daifeng Dong, Qingsen Ming, Yidian Gao, Ge Xiong, Chang Cheng, Haofei Zhao, Xiang Wang, Shuqiao Yao
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Psychology, Developmental
Yidian Gao, Yali Jiang, Qingsen Ming, Jibiao Zhang, Ren Ma, Qiong Wu, Daifeng Dong, Xiaoqiang Sun, Jiayue He, Wanyi Cao, Shuwen Yuan, Shuqiao Yao
Summary: Childhood maltreatment poses a serious risk to children's well-being and can lead to maladaptive behaviors, including conduct disorder. This study used VBM and SBM to investigate the impact of CD diagnosis and CM on the brains of boys with CD and typically developing boys. The results revealed distinct brain structural changes associated with CM among boys diagnosed with CD, potentially contributing to increased aggression and conduct problems in this population.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Yali Jiang, Yidian Gao, Daifeng Dong, Xiaoqiang Sun, Weijun Situ, Shuqiao Yao
Summary: The study found that CD patients with CU traits had decreased global efficiency in brain topology, as well as decreased nodal efficiency in the right amygdala, which may contribute to abnormal information processing and integration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Developmental
Yali Jiang, Yidian Gao, Daifeng Dong, Xiaoqiang Sun, Weijun Situ, Shuqiao Yao
Summary: This study investigated morphological differences in the brains of Chinese adolescents diagnosed with conduct disorder (CD) using surface-based morphometry methods. The results showed that adolescents with low callous unemotional (CU) traits, compared to healthy controls, had increased cortical surface area in the left inferior temporal cortex and right precuneus, but decreased surface area in the left superior temporal cortex. There were no significant differences in cortical surface area between adolescents with high CU traits and healthy controls. Additionally, adolescents with low CU traits had greater cortical thickness in the left rostral middle frontal cortex compared to those with high CU traits.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Yali Jiang, Yidian Gao, Daifeng Dong, Xiaoqiang Sun, Weijun Situ, Shuqiao Yao
Summary: Aggression is a core feature of conduct disorder, but the motivation and execution of aggression can vary. This study found that impulsive aggression and premeditated aggression have different neural substrates and correlations with amygdala volume.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2022)
Article
Neuroimaging
Ge Xiong, Daifeng Dong, Chang Cheng, Yali Jiang, Xiaoqiang Sun, Jiayue He, Chuting Li, Yidian Gao, Xue Zhong, Haofei Zhao, Xiang Wang, Shuqiao Yao
Summary: The study found that both currently depressed and remitted major depressive disorder patients had decreased volumes in the left pallidum and pulvinar anterior of thalamus, indicating trait markers. Additionally, subcortical structural covariance networks of these patients showed reduced small-world-ness and path length, suggesting a trait-like topological feature of depression.
NEUROIMAGE-CLINICAL
(2021)
Article
Psychology, Multidisciplinary
Yidian Gao, Yali Jiang, Qingsen Ming, Jibiao Zhang, Ren Ma, Qiong Wu, Daifeng Dong, Xiao Guo, Mingli Liu, Xiang Wang, Weijun Situ, Ruth Pauli, Shuqiao Yao
FRONTIERS IN PSYCHOLOGY
(2020)
Article
Family Studies
Jiayue He, Xue Zhong, Yidian Gao, Ge Xiong, Shuqiao Yao
CHILD ABUSE & NEGLECT
(2019)
Article
Psychology, Multidisciplinary
Chang Cheng, Daifeng Dong, Yali Jiang, Qingsen Ming, Xue Zhong, Xiaoqiang Sun, Ge Xiong, Yidian Gao, Shuqiao Yao
FRONTIERS IN PSYCHOLOGY
(2019)
Article
Psychology, Multidisciplinary
Daifeng Dong, Yali Jiang, Yidian Gao, Qingsen Ming, Xiang Wang, Shuqiao Yao
FRONTIERS IN PSYCHOLOGY
(2019)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)