Article
Clinical Neurology
Jessica K. Bone, Gemma Lewis, Jonathan P. Roiser, Sarah-Jayne Blakemore, Glyn Lewis
Summary: The study found that adolescents who recalled more self-referential negative words had more severe depressive symptoms, and this association was stronger in females.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Emma Brann, Christina Malavaki, Emma Fransson, Maria-Konstantina Ioannidi, Hanna E. Henriksson, Fotios C. Papadopoulos, George P. Chrousos, Maria Klapa, Alkistis Skalkidou
Summary: The study found that alterations in metabolites in postpartum depressive symptom samples could indicate oxidative stress conditions and provide information on the pathophysiology of postpartum depression. Future studies need to standardize analysis of different subgroups for further investigation.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Qiang Mao, Tian Tian, Jing Chen, Xunyi Guo, Xueli Zhang, Tao Zou
Summary: This study identified 79 significant differential metabolites between antenatal depression and non-antenatal depression, mainly influencing amino acid metabolism and glycerophospholipid metabolism. The simplified biomarker panel consisting of betaine, PC (16:0/16:0), and succinic acid showed excellent diagnostic performance in discriminating antenatal depression and non-antenatal depression.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Suyeon Kim, Eunsoo Won, Hyun-Ghang Jeong, Moon-Soo Lee, Young-Hoon Ko, Jong-Woo Paik, Changsu Han, Byung-Joo Ham, Eunsoo Choi, Kyu-Man Han
Summary: This study found a significant association between workplace gender discrimination and the prevalence of depressive symptoms among female employees.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
William Magee, Philippa Clarke
Summary: Research suggests that smoking may have a negative effect on reducing depressive symptoms among women, but the effect is not statistically significant among men, with no observed differences across race. The reciprocal effect of depressive symptoms on smoking needs to be taken into account in analyses to fully understand the relationship.
ADDICTIVE BEHAVIORS
(2021)
Article
Clinical Neurology
Deepa Shokeen, Karen Sokal-Gutierrez
Summary: The study found a significant association between cardio-metabolic risk factors and clinically-significant depressive symptoms among US adults, with an increased number of CMR factors correlating with increased odds of CSD symptoms. The findings suggest the importance of comprehensive interventions addressing both mental health and physical health issues.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Public, Environmental & Occupational Health
Yue Sun, Yiwen Zhong, Wenzhao Sun, Lingjun Chu, Jiang Long, Xi Wang Fan
Summary: This study examines gender differences in symptoms of Chinese adolescents with depression and finds that females have higher rates of depression and more severe depressive symptoms compared to males across different age groups. The analysis also reveals an earlier onset of depression among Chinese adolescents compared to previous studies in Western countries. This highlights the importance of gender equality and gender-friendly interventions in maintaining the overall mental health of adolescents in China.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Sofiene Chenini, Lucie Barateau, Lily Guiraud, Claire Denis, Ana Laura Rassu, Regis Lopez, Isabelle Jaussent, Yves Dauvilliers
Summary: The study found that the frequency of depressive symptoms and suicidal thoughts was significantly higher in patients with restless legs syndrome (RLS) compared to controls. Current major depressive episode and suicide risk were also high, with associations with factors such as young age, female sex, insomnia symptoms, and urgency.
MOVEMENT DISORDERS
(2022)
Review
Health Care Sciences & Services
Marianna Mazza, Georgios D. Kotzalidis, Carla Avallone, Marta Balocchi, Ilenia Sessa, Ilaria De Luca, Daniele Hirsch, Alessio Simonetti, Delfina Janiri, Emanuela Loi, Giuseppe Marano, Gabriella Albano, Vittorio Fasulo, Stefania Borghi, Angela Gonsalez del Castillo, Anna Maria Serio, Laura Monti, Daniela Chieffo, Gloria Angeletti, Luigi Janiri, Gabriele Sani
Summary: This study aimed to quantify the extent of depression in expecting fathers and compare it with the depression in their pregnant partners. The findings showed that paternal depression occurs at lower rates (around 5%) compared to maternal depression, indicating the existence of a distinct clinical entity. However, expecting women and new mothers are more likely to experience depression than expecting partners or new fathers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Robert Avramut, Serban Talpos, Camelia Szuhanek, Marius Pricop, Roxana Talpos, Tareq Hajaj, Nicoleta Nikolajevic-Stoican, Raluca Maracineanu, Roxana Ghircau-Radu, Malina Popa
Summary: This study aimed to investigate the sex-based differences in anxiety, depressive symptoms, and coping strategies among orthognathic patients. The findings revealed that female patients had higher levels of depression and anxiety, and coping mechanisms varied between male and female participants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Lewis R. Anderson, Christiaan W. S. Monden, Erzsebet Bukodi
Summary: Prior research suggests that women and less educated individuals are more likely to experience increases in depressive symptoms in response to stressful life events. However, using a new approach, it was found that these apparent differences were due to confounding and in reality, there is no significant difference between men and women in terms of vulnerability to depressive symptoms after stressful events, except for a tentative stronger association among women for events occurring in the household.
JOURNAL OF HEALTH AND SOCIAL BEHAVIOR
(2022)
Article
Psychiatry
Luis Roxo, Julian Perelman
Summary: This study assessed the factors associated with perception of need and affordability concerns regarding mental health services among individuals with depressive symptoms in Portugal. It found that unrecognized need and affordability concerns were common among depressed individuals, but were unevenly distributed across social groups. Gender, age, education, and symptom severity were identified as important factors influencing these perceptions.
PSYCHIATRY RESEARCH
(2022)
Article
Geriatrics & Gerontology
L. -T. Wang, W. -C. Huang, Y. -C. Hung, Jong-Hwan Park
Summary: The study found a non-linear association between depressive symptoms and sarcopenia risks in older adults, with more severe depressive symptoms being associated with higher risks of sarcopenia. Therefore, alleviating depressive symptoms may be an effective strategy for preventing sarcopenia in the older adult population.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Pediatrics
Vladislav Ruchkin, Andrew Stickley, Roman Koposov, Denis G. Sukhodolsky, Johan Isaksson
Summary: Research on the association between depressive symptoms and aggression among adolescents has yielded inconsistent findings. This study examines the prevalence of clinically significant and subthreshold depressive symptoms in a general population sample of adolescents from Northern Russia, and explores their relationship with aggression and anger, taking into account comorbid mental health problems. The results indicate that the severity of depression is positively correlated with anger, aggression, and comorbid problems. These findings suggest that interventions aimed at reducing aggressive behavior in adolescents should consider depression and its comorbid conditions.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Oliwia Gawlik-Kotelnicka, Anna Skowronska, Aleksandra Margulska, Karolina H. Czarnecka-Chrebelska, Igor Loniewski, Karolina Skonieczna-Zydecka, Dominik Strzelecki
Summary: This study protocol aims to assess the effects of probiotic supplementation on symptoms of depression, metabolic parameters, inflammatory markers, and fecal microbiota in patients with depressive disorders. The trial may establish a safe and easy-to-use adjunctive treatment option for patients who are partially responsive to pharmacologic therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Tae-Sung Yeum, Bora Kim, Eun Young Kim, Se Hyun Kim, Kyooseob Ha, Yong Min Ahn
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2018)
Article
Psychology, Clinical
Ji Hyun Baek, Kyooseob Ha, Yongkang Kim, Young-ah Cho, So Yung Yang, Yujin Chois, Sung-Lee Jang, Taesung Park, Tae Hyon Has, Kyung Sue Hong
PSYCHOLOGICAL MEDICINE
(2019)
Article
Clinical Neurology
C. Hyung Keun Park, Hyeyoung Kim, Bora Kim, Eun Young Kim, Hyun Jeong Lee, Daewook Kim, Yong Min Ahn
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2019)
Editorial Material
Psychiatry
Kyooseob Ha, Tae Hyon Ha, Kyung Sue Hong
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2019)
Article
Psychiatry
Sang Jin Rhee, Dohyun Han, Yunna Lee, Hyeyoung Kim, Junhee Lee, Kangeun Lee, Hyunsuk Shin, Hyeyoon Kim, Tae Young Lee, Minah Kim, Se Hyun Kim, Yong Min Ahn, Jun Soo Kwon, Kyooseob Ha
Article
Psychiatry
Tae Young Lee, Junhee Lee, Hyun Ju Lee, Yunna Lee, Sang Jin Rhee, Dong Yeon Park, Myung Jae Paek, Eun Young Kim, Euitae Kim, Sungwon Roh, Hee Yeon Jung, Minah Kim, Se Hyun Kim, Dohyun Han, Yong Min Ahn, Kyooseob Ha, Jun Soo Kwon
FRONTIERS IN PSYCHIATRY
(2020)
Review
Clinical Neurology
Liranso Gselamu, Kyooseob Ha
JOURNAL OF AFFECTIVE DISORDERS
(2020)
Article
Medical Informatics
Bora Kim, Younghoon Kim, C. Hyung Keun Park, Sang Jin Rhee, Young Shin Kim, Bennett L. Leventhal, Yong Min Ahn, Hyojung Paik
JMIR MEDICAL INFORMATICS
(2020)
Article
Clinical Neurology
Hyunju Lee, C. Hyung Keun Park, Sang Jin Rhee, Jayoun Kim, Bora Kim, Sang Sin Lee, Kyooseob Ha, Chang Jae Baik, Yong Min Ahn
Summary: This study identified that permissive attitude, low income, and fatalistic attitude were associated with high suicide rates in South Korea. In contrast, resilience to stress was found to protect against suicidal ideation in the United States and Japan. However, the exclusion of adults over 60 in the sample limited the generalizability of the results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Hyunju Lee, C. Hyung Keun Park, Sang Jin Rhee, Bora Kim, Sang Sin Lee, Kyooseob Ha, Chang Jae Baik, Yong Min Ahn
Summary: This study investigates the influence of poverty on suicide using a structural equation model, identifying common and distinctive factors associated with suicide in different countries. Results show that societal attribution of poverty, permissive attitude towards suicide, and income have significant impacts on the severity of suicidal thoughts across all nations studied.
COMPREHENSIVE PSYCHIATRY
(2021)
Article
Psychology, Clinical
Peter J. Na, Brandon Nichter, Melanie L. Hill, Bora Kim, Sonya B. Norman, Robert H. Pietrzak
Summary: Substance use is a strong risk factor for suicidal behavior, and optimal cut-off scores on measures like AUDIT and SDU can help identify individuals at elevated risk. Among U.S. veterans, a significant proportion reported past-year suicidal ideation and alcohol/drug use disorders, with specific cut-off scores indicating moderate-to-severe alcohol use disorder (>14, >18) and drug use disorder (>1). These findings can inform suicide risk assessment in veterans with substance use issues.
ADDICTIVE BEHAVIORS
(2021)
Article
Psychology, Developmental
Bora Kim, Mina Ha, Young Shin Kim, Yun-Joo Koh, Shan Dong, Ho-Jang Kwon, Young-Suk Kim, Myung-Ho Lim, Ki-Chung Paik, Seung-Jin Yoo, Hosanna Kim, Patricia S. Hong, Stephan J. Sanders, Bennett L. Leventhal
Summary: The study found that paternal smoking before pregnancy significantly increased the risk of offspring developing autism spectrum disorder, while smoking during pregnancy was also a risk factor. Smoking prevention may be beneficial in reducing the risk of autism spectrum disorder in offspring.
Article
Medicine, General & Internal
Jeong Hun Yang, Sang Jin Rhee, C. Hyung Keun Park, Min Ji Kim, Daun Shin, Jae Won Lee, Junghyun Kim, Hyeyoung Kim, Hyun Jeong Lee, Kyooseob Ha, Yong Min Ahn
Summary: This study suggests that self-transcendence may mediate the relationship between early trauma and suicide attempts using fatal methods, indicating a potential increase in suicide risk.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Medicine, General & Internal
Inhwan Park, Jared Gong, Gregory L. Lyons, Tomoya Hirota, Michio Takahashi, Bora Kim, Seung Yeon Lee, Young Shin Kim, Jeongsoo Lee, Bennett L. Leventhal
YONSEI MEDICAL JOURNAL
(2020)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)