Review
Biochemistry & Molecular Biology
Lais Murta, Daniela Seixas, Luana Harada, Rodolfo Furlan Damiano, Marcus Zanetti
Summary: Recent studies have shown positive effects of Intermittent Fasting (IF) on metabolic parameters, cognition, and mood. However, the effect of IF on depressive symptoms is still unclear. This review assessed the available evidence on IF interventions for depression in both clinical and preclinical studies. Studies on rodents suggest that IF acts as a circadian regulator, improving neurotransmitter availability and increasing neurotrophic factors in the brain. However, studies on humans mainly evaluated healthy volunteers and showed heterogeneity in both the IF regimens studied and the effects on mood. Better designed studies and controlled evaluations are needed to assess the efficiency of IF in treating major depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Psychology, Clinical
Kevin S. O'Connell, Brandon J. Coombes
Summary: Bipolar disorder is a highly heritable mental disorder with significant genetic overlap with other psychiatric disorders. Genetic studies suggest that the number of associated loci is expected to increase substantially in larger future studies, but challenges remain in fully characterizing the genetic architecture of BD.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Raneem Jatal, Sofia Mendes Saraiva, Carlos Vazquez-Vazquez, Eric Lelievre, Olivier Coqueret, Rafael Lopez-Lopez, Maria de la Fuente
Summary: The accumulation of senescent cells can lead to the development of age-related diseases, including cancer. Research has found that the 4N1Ks peptide has the potential to target and eliminate senescent cells. However, peptide drugs have limitations that reduce their efficacy, so the study proposes the use of biodegradable nanosystems decorated with the 4N1Ks peptide. Experimental results show that these nanosystems have suitable properties and demonstrate improved therapeutic effects on cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Clinical Neurology
Kelly A. Ryan, Peisong Han, Yuhua Zhang, David F. Marshall, Anastasia K. Yocum, Melvin G. McInnis, Sebastian Zollner
Summary: Individuals with bipolar disorder tend to have higher neuroticism and lower extraversion and consciousness compared to healthy controls. Personality traits show only small changes over time, with neuroticism being the only trait associated with changes in mood state. Other factors beyond mood changes may influence changes in personality traits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Tomonari Hayasaka, Yoshikazu Takaesu, Izumi Nagashima, Miku Futada, Kazuhiro Nozaki, Takeshi Katagiri, Yayoi Imamura, Mariko Kurihara, Yuki Oe, Takashi Tsuboi, Koichiro Watanabe
Summary: The study found significant associations between word count of transcription task and mood status after occupational therapy and time to achieve employment in patients with mood disorders. These factors could be important predictors for patient's employment outcomes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Immunology
Eric A. Meyerowitz, Shibani S. Mukerji, G. Kyle Harrold, Rachel M. Erdil, Steven T. Chen, Emily A. Rudmann, Athe Tsibris, Nagagopal Venna, Gregory K. Robbins
Summary: Mogamulizumab shows potential for improving symptoms in patients with HAM/TSP, but more clinical trials are needed to confirm its effectiveness.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Psychology, Clinical
Brett D. M. Jones, Brisa S. Fernandes, M. Ishrat Husain, Abigail Ortiz, Tarek K. Rajji, Daniel M. Blumberger, Meryl A. Butters, Ariel G. Gildengers, Tatiana Shablinski, Aristotle Voineskos, Benoit H. Mulsant
Summary: This study aims to explore the relationships among clinical characteristics of bipolar disorder (BD), cognitive dysfunction, and aging. The results support both an early impairment model and an accelerated aging model, indicating that different cognitive domains are affected differently by BD and aging.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tarapati Rana, Tapan Behl, Aayush Sehgal, Vineet Mehta, Sukhbir Singh, Ravinder Kumar, Simona Bungau
Summary: Depression is a common mental disorder and accurately diagnosing it is challenging, leading to the search for new biomarkers in psychotherapy. The endocannabinoid system plays a crucial role in the development of depression, and improving endocannabinoid signaling may represent a new therapeutic approach for managing depressive disorders.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Editorial Material
Psychiatry
Gin S. Malhi, Erica Bell, Kamaldeep Bhui
Summary: The 11th revision of the ICD brings significant advancements but also compromises that may negatively affect clinical practice, as illustrated in this editorial focusing on mood disorders and bipolar disorder subtyping.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Michelle Chao, Jun Min Koay, Anna Van Meter
Summary: This study used a smartphone-based design to evaluate the influence of mood on judgment. The results showed that mood did not have a significant effect on individuals' judgments. Prior task performance and task trial were significant predictors of self-efficacy; sex and task trial were associated with face emotion recognition; and balloons popped the day prior, and task trial influenced individuals' evaluation of risk.
CURRENT PSYCHOLOGY
(2022)
Article
Immunology
Mariele Guerra, Natalia B. Carvalho, Silvane Santos, Mauricio T. T. Nascimento, Renata Sa, Augusto M. M. Carvalho, Edgar M. M. Carvalho, Lucas P. P. Carvalho
Summary: This study found that HTLV-1 infected individuals, especially those with HAM/TSP, have higher levels of MMP-9 production. MMP-9 levels are positively correlated with viral load and TNF levels. These findings suggest an association between MMP-9 production and the proinflammatory state associated with HTLV-1 infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Roberto S. Accolla
Summary: This review discusses the expression of HTLV-1 basic leucine-zipper factor HBZ during HTLV-1 infection, providing a deeper understanding of HTLV-1 infection and oncogenesis mechanisms, and suggesting new directions for further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Anesthesiology
Mari Glette, Tore C. Stiles, Mark P. Jensen, Tom Ivar Lund Nilsen, Petter C. Borchgrevink, Tormod Landmark
Summary: The study suggests that increases in pain intensity and catastrophizing are independently associated with increases in depressive symptoms. Chronic pain increases the risk of developing depression over the following years, and the number of years with chronic pain is associated with a chronic course of depression.
Article
Microbiology
Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Satoshi Nozuma, Eiji Matsuura, Hiroshi Takashima, Shuji Izumo, Ryuji Kubota
Summary: The study compared the performance of different detection methods in the CSF of HAM/TSP patients and HTLV-1 carriers, demonstrating that CLIA was closer to PA in performance, while CLEIA had lower sensitivity.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tarapati Rana, Tapan Behl, Aayush Sehgal, Vineet Mehta, Sukhbir Singh, Neelam Sharma, Simona Bungau
Summary: FoxO transcriptional factors play essential roles in the pathophysiology of depression, potentially regulated by upstream mediators like BDNF and protein kinase B. They are also influenced by serotonin, noradrenaline, and the HPA axis, and may serve as therapeutic targets for managing depressive disorder.
NEUROCHEMICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kazue Hisaoka-Nakashima, Kanako Miyano, Chie Matsumoto, Naoto Kajitani, Hiromi Abe, Mami Okada-Tsuchioka, Akinobu Yokoyama, Yasuhito Uezono, Norimitsu Morioka, Yoshihiro Nakata, Minoru Takebayashi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Naoto Kajitani, Kazue Hisaoka-Nakashima, Mami Okada-Tsuchioka, Mayu Hosoi, Toshiki Yokoe, Norimitsu Morioka, Yoshihiro Nakata, Minoru Takebayashi
JOURNAL OF NEUROCHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Hiromi Abe, Kazue Hisaoka-Nakashima, Naoto Kajitani, Mami Okada-Tsuchioka, Ryoya Yano, Kei Itagaki, Chiyo Shibasaki, Norimitsu Morioka, Yoshihiro Nakata, Minoru Takebayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Neurosciences
Kazue Hisaoka-Nakashima, Naoto Kajitani, Masahiro Kaneko, Takahiro Shigetou, Miho Kasai, Chie Matsumoto, Toshiki Yokoe, Honami Azuma, Minoru Takebayashi, Norimitsu Morioka, Yoshihiro Nakata
Article
Clinical Neurology
Chiyo Shibasaki, Minoru Takebayashi, Kei Itagaki, Hiromi Abe, Naoto Kajitani, Mami Okada-Tsuchioka, Shigeto Yamawaki
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Naoto Kajitani, Kanako Miyano, Mami Okada-Tsuchioka, Hiromi Abe, Kei Itagaki, Kazue Hisaoka-Nakashima, Norimitsu Morioka, Yasuhito Uezono, Minoru Takebayashi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Clinical Neurology
Chiyo Shibasaki, Kei Itagaki, Hiromi Abe, Naoto Kajitani, Mami Okada-Tsuchioka, Minoru Takebayashi
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Clinical Neurology
Kei Itagaki, Minoru Takebayashi, Chiyo Shibasaki, Naoto Kajitani, Hiromi Abe, Mami Okada-Tsuchioka, Shigeto Yamawaki
JOURNAL OF AFFECTIVE DISORDERS
(2017)
Article
Clinical Neurology
Kei Itagaki, Minoru Takebayashi, Hiromi Abe, Chiyo Shibasaki, Naoto Kajitani, Mami Okada-Tsuchioka, Kotaro Hattori, Sumiko Yoshida, Hiroshi Kunugi, Shigeto Yamawaki
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Clinical Neurology
Wataru Omori, Kei Itagaki, Naoto Kajitani, Hiromi Abe, Mami Okada-Tsuchioka, Yasumasa Okamoto, Minoru Takebayashi
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Naoto Kajitani, Mami Okada-Tsuchioka, Kuniyuki Kano, Wataru Omori, Shuken Boku, Junken Aoki, Minoru Takebayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Clinical Neurology
Wataru Omori, Kotaro Hattori, Naoto Kajitani, Mami Okada-Tsuchioka, Shuken Boku, Hiroshi Kunugi, Yasumasa Okamoto, Minoru Takebayashi
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Clinical Neurology
Wataru Omori, Kuniyuki Kano, Kotaro Hattori, Naoto Kajitani, Mami Okada-Tsuchioka, Shuken Boku, Hiroshi Kunugi, Junken Aoki, Minoru Takebayashi
Summary: The study found significantly lower levels of LPA 22:6 in patients with MDD and SCZ compared to healthy controls, with a negative correlation with clinical symptom scores in MDD patients. Additionally, the levels of LPA 22:6 were significantly correlated with LPC 22:6 levels among all 3 groups, but not with ATX activity in MDD and SCZ patients.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kazue Hisaoka-Nakashima, Toshiki Yokoe, Shintaro Watanabe, Yoki Nakamura, Naoto Kajitani, Mami Okada-Tsuchioka, Minoru Takebayashi, Yoshihiro Nakata, Norimitsu Morioka
Summary: The study demonstrates that LPA increases TSP-1 production in astrocytes through activation of LPA(1/3) receptors, involving Gi/o-coupled LPA(1) and LPA(3) receptors.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Mami Okada-Tsuchioka, Wataru Omori, Naoto Kajitani, Chiyo Shibasaki, Kei Itagaki, Minoru Takebayashi
NEUROPSYCHOPHARMACOLOGY REPORTS
(2020)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)