Review
Genetics & Heredity
Efthalia Angelopoulou, Anastasia Bougea, Sokratis G. Papageorgiou, Chiara Villa
Summary: Psychosis in Parkinson's disease (PDP) is a common and debilitating condition that significantly affects the quality of life for both patients and caregivers. It is associated with various risk factors such as age, sleep disturbances, disease duration, cognitive impairment, depression, and visual disorders. The pathophysiology of PDP is complex and not fully understood, and some medications used to treat PD can worsen or even precipitate PDP.
Article
Multidisciplinary Sciences
Sneha Mantri, Emily Klawson, Steven Albert, Robyn Rapoport, Chelle Precht, Sarah Glancey, Margaret Daeschler, Eugenia Mamikonyan, Catherine M. Kopil, Connie Marras, Lana M. Chahine
Summary: This study investigates the experiences and needs of care partners of individuals with Parkinson's disease psychosis, revealing challenges in navigating the medical system and communicating with professionals. It emphasizes the importance of providing additional support to strained care partners.
Review
Psychiatry
Shun Kudo, Takahito Uchida, Hana Nishida, Akihiro Takamiya, Toshiaki Kikuchi, Bun Yamagata, Masaru Mimura, Jinichi Hirano
Summary: This study examined the clinical background of patients who underwent maintenance ECT and found a higher prevalence of melancholic and catatonic features in the maintenance ECT group compared to the acute ECT group. The study also suggests that patients receiving both acute and maintenance ECT may have underlying neurodegenerative diseases, including PD/DLB.
Article
Behavioral Sciences
David Howells, John Rees, Rebecca Townsend, George Kirov
Summary: This is a case report of a 72-year-old male patient with severe depression and psychotic symptoms who underwent electroconvulsive therapy (ECT). A SPECT scan revealed abnormal brain perfusion, and after 12 sessions of ECT, his symptoms improved along with cognitive performance. A repeat SPECT scan showed substantial improvement in cerebral blood flow, favoring a diagnosis of depression rather than dementia.
Article
Clinical Neurology
Jan Booij, Sem P. Tellier, John Seibyl, Chris Vriend
Summary: This study reveals the influence of season and sunlight on dopamine transporter availability in early Parkinson's disease patients and healthy controls. The researchers found that DAT availability in the left caudate nucleus of PD patients was higher in spring and summer, and positively correlated with higher sun exposure. In addition, the latitude of the PPMI site was negatively associated with DAT availability in both PD patients and healthy controls.
MOVEMENT DISORDERS
(2023)
Article
Geriatrics & Gerontology
Nicole Mercado Fischer, Jared T. Hinkle, Kate Perepezko, Catherine C. Bakker, Meaghan Morris, Martinus P. G. Broen, Ankur Butala, Ted M. Dawson, Albert F. G. Leentjens, Zoltan Mari, Cherie L. Marvel, Kelly A. Mills, Liana S. Rosenthal, Melissa D. Shepard, Alexander Pantelyat, Arnold Bakker, Olga Pletnikova, Juan C. Troncoso, Jiangxia Wang, Gregory M. Pontone
Summary: The study found that some Parkinson's disease patients had psychosis and depression, which were closely related to neuronal loss and gliosis in the substantia nigra but not in the locus coeruleus. Psychosis and depression were associated with the severity of neuronal loss and gliosis in the substantia nigra, while anxiety did not show such association.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Psychiatry
Julia M. Lappin, Kimberley Davies, Maryanne O'Donnell, Ishan C. Walpola
Summary: This study aimed to understand the use of clozapine and electroconvulsive therapy (ECT) in individuals with treatment-resistant psychosis. The study found that the utilization of these treatments was low and clozapine trials were often terminated prematurely without adequate testing. The study suggests strategies should be implemented to optimize the use of clozapine therapy and ECT in clinical settings to improve the therapeutic effectiveness for treatment-resistant psychosis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Ioanna Pachi, Maria Maraki, Nikolaos Giagkou, Mary H. Kosmidis, Mary Yannakoulia, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Eva Ntanasi, Georgia Xiromerisiou, Maria Stamelou, Nikolaos Scarmeas, Leonidas Stefanis
Summary: The study suggests a possible association between prodromal Parkinson's disease and psychotic symptoms, with participants who developed psychotic manifestations having a higher probability of prodromal PD score. This association is mainly driven by depressive symptoms, constipation, and subthreshold parkinsonism.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Rajesh Pahwa, Stuart H. Isaacson, Gary W. Small, Yasar Torres-Yaghi, Fernando Pagan, Marwan Sabbagh
Summary: Hallucinations and delusions are debilitating non-motor symptoms in Parkinson's disease, but often go unreported. A panel of experts developed a simple screening tool and treatment guidance to assist in the diagnosis and management of Parkinson's disease psychosis.
NEUROLOGY AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Natasha S. R. Bidesi, Ida Vang Andersen, Albert D. Windhorst, Vladimir Shalgunov, Matthias M. Herth
Summary: Parkinson's disease is a widespread neurodegenerative disorder characterized by alpha-synuclein accumulation and dopaminergic neurons loss. Molecular imaging techniques such as MRI, SPECT, and PET have shown effectiveness in aiding clinical diagnosis and understanding the heterogeneity of PD. However, challenges remain in using molecular imaging for early diagnosis and differentiation from atypical parkinsonisms.ongoing research focuses on new imaging targets, particularly alpha-synuclein, for detecting pathological changes related to PD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Clinical Neurology
Ioanna Pachi, Vassilis Papadopoulos, Lida Alkisti Xenaki, Christos Koros, Athina Maria Simitsi, Anastasia Bougea, Maria Bozi, Nikos Papagiannakis, Rigas Filippos Soldatos, Dimitra Kolovou, George Pantes, Nikolaos Scarmeas, Georgios Paraskevas, Konstantinos Voumvourakis, Constantin Potagas, Sokratis G. Papageorgiou, Konstantinos Kollias, Nikos Stefanis, Leonidas Stefanis
Summary: This study aimed to explore the correlations between JtC tendency and neuropsychiatric features in early PD. The results showed a high prevalence of JtC bias in PD patients, which was associated with motor symptoms and impulsivity. These findings contribute to understanding the cognitive and psychiatric characteristics of PD.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Beatrice Heim, Marina Peball, Florian Krismer, Atbin Djamshidian, Klaus Seppi
Summary: Parkinson's disease (PD) is the second-most common neurodegenerative disorder, and PD psychosis (PDP) has a cumulative prevalence of 60%. Limited medical treatment options currently exist for PDP, with only a few atypical antipsychotic drugs with low affinity to dopamine D2 receptors. In 2016, pimavanserin, a selective 5-HT2A inverse agonist/antagonist, was approved by the FDA as the only treatment for PDP. This article provides an overview of PDP's epidemiology, pathophysiology, treatment options, and the mode of action and study data of pimavanserin.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe Arriva Pitella, Ana Carolina Trevisan, Leonardo Alexandre-Santos, Mery Kato, Manuelina Mariana Capellari Macruz Brito, Vitor Tumas, Lauro Wichert-Ana
Summary: This study aimed to evaluate different quantitative indexes of striatum dopamine transporter density in healthy subjects and patients with Parkinson's disease (PD). The results showed that the binding potential index (BPI) had higher sensitivity and specificity in differentiating PD and healthy subjects, while the asymmetry index (AI) and putamen/caudate ratio (P/C) had lower performance and reliability. Caution should be exercised when using AI and P/C.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Clinical Neurology
Simo Nuuttila, Mikael Eklund, Juho Joutsa, Elina Jaakkola, Elina Makinen, Emma A. Honkanen, Kari Lindholm, Tommi Noponen, Toni Ihalainen, Kirsi Murtomaki, Tanja Nojonen, Reeta Levo, Tuomas Mertsalmi, Filip Scheperjans, Valtteri Kaasinen
Summary: The study on Parkinson's disease (PD), essential tremor (ET), and healthy controls found that the Glabellar tap reflex (GR) cannot effectively differentiate between PD and ET patients, and it exhibits significant inconsistency over time.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Clinical Neurology
Victor Abler, Cecilia Brain, Clive Ballard, Ana Berrio, Bruce Coate, Alberto. J. J. Espay
Summary: The study found that Pimavanserin 34 mg was well tolerated and did not have a negative impact on motor or cognition in patients with PD psychosis. Rates of motor- and cognition-related adverse events were similar between Pimavanserin and placebo.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
M. Judith Peterschmitt, Hidemoto Saiki, Taku Hatano, Thomas Gasser, Stuart H. Isaacson, Sebastiaan J. M. Gaemers, Pascal Minini, Stephane Saubadu, Jyoti Sharma, Samantha Walbillic, Roy N. Alcalay, Gary Cutter, Nobutaka Hattori, Gunter U. Hoeglinger, Kenneth Marek, Anthony H. Schapira, Clemens R. Scherzer, Tanya Simuni, Nir Giladi, Sergio Pablo Sardi, Tanya Z. Fischer
Summary: This study evaluated the pharmacology, safety, and tolerability of the glucosylceramide synthase inhibitor venglustat in patients with Parkinson's disease and GBA mutations. The results showed favorable safety and tolerability of venglustat in both Japanese and non-Japanese participants, with target engagement achieved in cerebrospinal fluid.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
Cloe Domenighetti, Pierre-Emmanuel Sugier, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Oceane Mohamed, Berta Portugal, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimos Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Stefano Duga, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Yusuke Kawamura, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart Pc van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy L. Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Clara Hellberg, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Krueger, Thomas Gasser, Manu Sharma, Alexis Elbaz
Summary: This study used a two-sample Mendelian randomization method to analyze the associations of smoking, alcohol drinking, and coffee drinking with Parkinson's disease (PD). The results showed that smoking was inversely associated with PD, while genetic liability was positively associated with PD. The associations of alcohol drinking and coffee drinking with PD were limited by insufficient statistical power.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Behavioral Sciences
Jinyoung Youn, Genko Oyama, Nobutaka Hattori, Yasushi Shimo, Tomi Kuusimaki, Valtteri Kaasinen, Angelo Antonini, Dongyeop Kim, Jung-Il Lee, Kyung Rae Cho, Jin Whan Cho
Summary: This multicenter retrospective study investigated the long-term outcome of bilateral subthalamic deep brain stimulation (DBS) in Parkinson's disease (PD) patients with SNCA mutations. The study found that subthalamic DBS could be beneficial for motor fluctuation in PD patients with SNCA mutations, especially those with SNCA duplication. However, cognitive and psychiatric symptoms are important factors influencing the long-term outcome of subthalamic DBS.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Nobutaka Hattori, Yuki Kogo, Michinori Koebis, Takayuki Ishida, Ippei Suzuki, Yoshio Tsuboi, Masahiro Nomoto
Summary: The results of this post-hoc analysis of a Japanese study suggest that safinamide as an adjunct therapy could potentially benefit PD patients with mild depression and pain during the OFF phase. Additionally, safinamide may provide particular benefits for PD patients with mild apathy and female sex.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Haruka Takeshige-Amano, Taku Hatano, Koji Kamagata, Christina Andica, Wataru Uchida, Masahiro Abe, Takashi Ogawa, Yasushi Shimo, Genko Oyama, Atsushi Umemura, Masanobu Ito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattori
Summary: This study comprehensively assessed white matter microstructures in PD patients with ICBs using advanced diffusion MRI and MT-sat imaging. The results showed that compared with healthy controls, PD-nICBs had significant alterations in many major white matter tracts in most parameters. Compared with PD-ICBs, PD-nICBs had more prominent myelin and axonal changes in fibers related to the reward system and visual emotional recognition.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Mayuko Ogawa, Genko Oyama, Satoko Sekimoto, Taku Hatano, Nobutaka Hattori
Summary: In a specific cohort in Japan, patients with Parkinson's disease and their caregivers were mostly satisfied with the telemedicine service, finding it effective in reducing travel burden.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Letter
Clinical Neurology
Hikaru Kamo, Genko Oyama, Kenya Nishioka, Manabu Funayama, Nobutaka Hattori
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Tatou Iseki, Yuzuru Imai, Nobutaka Hattori
Summary: Leucine rich-repeat kinase 2 (LRRK2) is the most well-known genetic cause of familial Parkinson's disease (PD). Its functions and relationship to the pathogenesis of PD are not fully understood. Recent studies have suggested that LRRK2 plays a role in glial cell dysfunction and neurodegeneration, particularly in lysosomal dynamics and inflammation. This review discusses the proposed functions of LRRK2 in glial cells and its involvement in the pathomechanisms of PD.
Article
Medicine, General & Internal
Nobutaka Hattori, Yoshiko Okada, Yayoi Kawata, Yoshihiko Furusawa, Takumi Imai, Hisako Yoshida, Mihoko Ota, Masaki Arai, Ayumi Shintani, Jovelle Fernandez
Summary: This study aimed to investigate the impact of the COVID-19 pandemic on patients with Parkinson's disease and their caregivers in Japan. The results showed that over 40% of patients reduced their frequency of going out, approximately 7-30% experienced worsened symptoms, and caregivers reported increased burden. The findings suggest the importance of providing support to patients and caregivers during infectious disease epidemics to alleviate their burden.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Biochemistry & Molecular Biology
Yuri Yamashita, Satoshi Nakada, Kyoko Nakamura, Hidetoshi Sakurai, Kinji Ohno, Tomohide Goto, Yo Mabuchi, Chihiro Akazawa, Nobutaka Hattori, Eri Arikawa-Hirasawa
Summary: Schwartz-Jampel syndrome (SJS) is a rare genetic disorder characterized by myotonia. In this study, a cellular model of SJS was created using patient-derived induced pluripotent stem cells, which showed hyper-responsiveness to acetylcholine. These findings confirmed the use of cellular models in studying SJS and evaluating myotonia in clinical cases.
Editorial Material
Clinical Neurology
Nobutaka Hattori
NEURODEGENERATIVE DISEASE MANAGEMENT
(2023)
Article
Clinical Neurology
Christina Andica, Koji Kamagata, Wataru Uchida, Yuya Saito, Kaito Takabayashi, Akifumi Hagiwara, Haruka Takeshige-Amano, Taku Hatano, Nobutaka Hattori, Shigeki Aoki
Summary: This study compared the white matter differences between nonmedicated patients with early-stage GBA-PD and iPD using a novel technique, fixel-based analysis. The results showed that patients with GBA-PD had lower white matter density, while patients with iPD had larger white matter fiber bundles. These findings may be related to neurodegenerative diseases, α-synuclein accumulation, and cognitive and motor impairments.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Amica C. Mueller-Nedebock, Marieke C. J. Dekker, Matthew J. Farrer, Nobutaka Hattori, Shen-Yang Lim, George D. Mellick, Irena Rektorova, Mohamed Salama, Artur F. S. Schuh, A. Jon Stoessl, Carolyn M. Sue, Ai Huey Tan, Rene L. Vidal, Christine Klein, Soraya Bardien
Summary: The biological basis of Parkinson's disease, a neurodegenerative movement disorder, is still unclear despite being discovered over 200 years ago. This article summarizes the viewpoints of PD experts on the different theories regarding its pathobiology.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Wataru Sako, Yuki Kogo, Michinori Koebis, Yoshiaki Kita, Hajime Yamakage, Takayuki Ishida, Nobutaka Hattori
Summary: This study compared the efficacy, tolerability, and safety of different classes of anti-PD drugs in patients with fluctuating PD who were receiving levodopa. The results showed that ropinirole, pramipexole, and safinamide are well-balanced anti-PD drugs that have both good efficacy and tolerability.
NPJ PARKINSONS DISEASE
(2023)
Article
Biology
Davide Cossu, Yuji Tomizawa, Kazumasa Yokoyama, Tamami Sakanishi, Eiichi Momotani, Leonardo A. Sechi, Nobutaka Hattori
Summary: The study analyzed the levels of different IgG subclasses in the blood of Japanese and Italian individuals with relapsing remitting multiple sclerosis (MS) in response to MAP-derived peptides. The study also examined the effects of MAP peptides on MOG-induced experimental autoimmune encephalomyelitis (EAE) in mice. The results suggest a potential link between MAP and the development or exacerbation of MS, particularly in individuals with elevated serum IgG4 levels.
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)