Review
Biochemistry & Molecular Biology
Vincenzo Giuseppe Nicoletti, Krisztian Pajer, Damiano Calcagno, Gholam Pajenda, Antal Nogradi
Summary: Mature neurotrophic factors and their propeptides are crucial in regulating neuronal growth, survival, and recovery. Understanding the mechanisms of these factors offers potential for neuroregenerative medicine.
Article
Cell Biology
Maryna Koskela, T. Petteri Piepponen, Maria Lindahl, Brandon K. Harvey, Jaan-Olle Andressoo, Vootele Voikar, Mikko Airavaara
Summary: The study explored the impact of GDNF and BDNF on alcohol-seeking behavior in group-housed female mice. While an increase in endogenous Gdnf mRNA level was found to affect behavioral responses to alcohol consumption, overexpression of AVV-GDNF in the nucleus accumbens suppressed alcohol-seeking behavior.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Doaa Fathi, Ahmed I. Abulsoud, Muhammed A. Saad, Noha N. Nassar, Mina M. Maksimos, Sherine M. Rizk, Mahmoud A. Senousy
Summary: Agomelatine treatment in a rat model of alcoholism led to a significant decrease in alcohol consumption and positive effects on behavior and biochemical markers. Agomelatine reversed alcohol cravings and withdrawal symptoms associated with alcohol dependence by modulating the Notch1 signaling pathway.
Review
Biochemistry & Molecular Biology
Ava Nasrolahi, Fatemeh Javaherforooshzadeh, Mohsen Jafarzadeh-Gharehziaaddin, Javad Mahmoudi, Khadijeh Dizaji Asl, Zahra Shabani
Summary: NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment, with potential to protect and treat neurodegenerative diseases.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Neurosciences
Wesley Stansberry, Brian Pierchala
Summary: The discovery of neurotrophins and their potential to save dying neurons in neurodegenerative diseases caused great excitement. Subsequent findings of the survival-promoting activity of BDNF, CNTF, and GDNF on motor neurons led to their proposed use in ALS. This review summarizes the literature on the role of NGF, BDNF, CNTF, and GDNF on spinal motor neuron development and physiology, as well as the preclinical studies and clinical trials evaluating their potential for ALS treatment.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Tatiana A. A. Mishchenko, Maria O. O. Klimenko, Alisa I. I. Kuznetsova, Roman S. S. Yarkov, Alexander G. G. Savelyev, Anastasia V. V. Sochilina, Alexandra O. O. Mariyanats, Vladimir K. K. Popov, Evgeny V. V. Khaydukov, Andrei V. V. Zvyagin, Maria V. V. Vedunova
Summary: Reconstruction of brain tissue after traumatic injury is a challenging task. In this study, a 3D hydrogel scaffold with specific biochemical properties was used to reconstruct brain tissue. The scaffold showed good biocompatibility and promoted neuronal process outgrowth and enhanced functional activity of neuro-glial networks. Animal experiments demonstrated the favorable regenerative potential of the scaffold for post-traumatic nerve tissue.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria S. Gavrish, Mark D. Urazov, Tatiana A. Mishchenko, Victoria D. Turubanova, Ekaterina A. Epifanova, Victoria G. Krut', Alexey A. Babaev, Maria V. Vedunova, Elena Mitroshina
Summary: The role of neurotrophic factors BDNF and GDNF in maintaining brain resistance to hypoxia and promoting recovery of neural networks is being actively studied. This study aimed to evaluate the effects of overexpressing BDNF and GDNF using viral vectors in modeling hypoxia. The results showed increased survival rate of mice under hypoxic conditions, indicating that overexpression of neurotrophic factors may be a potential neuroprotection method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Silvano Gallus, Alessandra Lugo, Elisa Borroni, Teo Vignoli, Lisa Lungaro, Giacomo Caio, Roberto De Giorgio, Giorgio Zoli, Fabio Caputo
Summary: This systematic review summarizes literature on major symptoms of protracted alcohol withdrawal in patients with alcohol use disorder. The pharmacological approach to manage protracted alcohol withdrawal ensures a more rapid reduction of symptoms (craving in particular), achieving in three weeks similar results obtained only after almost 6 months without treatment.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Damian Czarnecki, Marcin Ziolkowski, Jan Chodkiewicz, Marta Gorzkiewicz, Napoleon Waszkiewicz, Anna Dlugosz, Jacek Budzynski, Anna Junkiert-Czarnecka, Agnieszka Kulak-Bejda
Summary: This study aimed to assess changes in the severity of alcohol craving according to allelic variants of the 5-HTTLPR gene polymorphism during hospitalisation and their association with selected clinical variables in alcohol-dependent patients. The results showed that there was a decrease in the severity of alcohol craving at the 6th week of the follow-up in subjects with the short/short allele and long/short allele of the 5-HTTLPR gene.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2023)
Article
Cell Biology
Daniel Hellenbrand, Clayton L. Haldeman, Jae-Sung Lee, Angela G. Gableman, Elena K. Dai, Stephen D. Ortmann, Jerrod C. Gotchy, Kierra K. Miller, Adrianna M. Doucas, Nicole C. Nowak, William L. Murphy, Amgad S. Hanna
Summary: The gold standard for treating peripheral nerve injuries with large nerve gaps is autologous nerve grafts. However, incorporating mineral coated microparticles (MCMs) to release growth factors like NGF and GDNF can significantly enhance axon growth and improve limb function in rats with nerve grafts.
NEURAL REGENERATION RESEARCH
(2021)
Article
Substance Abuse
Rilana Schuster, Matthias Winkler, Anne Koopmann, Patrick Bach, Sabine Hoffmann, Iris Reinhard, Rainer Spanagel, J. Malte Bumb, Wolfgang H. Sommer, Falk Kiefer
Summary: The study suggests that oral administration of calcium carbonate can alleviate withdrawal symptoms and alcohol cravings in alcohol-dependent patients, demonstrating a potential therapeutic effect in controlled clinical pilot studies.
EUROPEAN ADDICTION RESEARCH
(2021)
Article
Psychiatry
Vatsalya Vatsalya, Joris C. Verster, Manasa Sagaram, Amor J. Royer, Huirong Hu, Ranganathan Parthasarathy, Melanie L. Schwandt, Maiying Kong, Vijay A. Ramchandani, Wenke Feng, Ruchita Agrawal, Xiang Zhang, Craig J. Mcclain
Summary: This study examined the role of gut dysfunction, proinflammatory cytokines, and hormones in characterizing symptoms of alcohol use disorder (AUD). The results showed that patients with clinically significant AUD exhibited higher levels of adiponectin and interleukin-6 compared to patients with clinically not-significant AUD. Additionally, craving was associated with gut dysregulation and proinflammatory markers.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Ran Zhu, Zhaojun Ni, Ran Tao, Jun Cheng, Liangjun Pang, Shun Zhang, Yang Zhang, Yanxue Xue, Yundong Ma, Wei Sun, Lin Lu, Jiahui Deng, Hongqiang Sun
Summary: Repeated exposure to olfactory stimulus during non-rapid eye movement sleep did not significantly affect cue reactivity and craving in patients with alcohol dependence.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Anna Mosiolek, Jadwiga Mosiolek, Slawomir Jakima, Aleksandra Pieta, Agata Szulc
Summary: Major depressive disorder (MDD) is a multifactorial disease with ongoing research on the role of neurotrophic factors in its pathophysiology. Antidepressant treatment can modify serum levels of neurotrophins, such as BDNF, leading to clinical improvement of MDD. Further research is needed to understand the correlation between different antidepressant drugs and neurotrophic factor serum levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Yong-Mei Wang, Ya-Yun Xu, Yi Zhai, Qian-Qian Wu, Wen Huang, Yan Liang, Yan-Hong Sun, Lian-Yin Xu
Summary: The study found that transcutaneous auricular vagus nerve stimulation (taVNS) can improve depression symptoms and sleep quality in alcohol-dependent patients after withdrawal, potentially due to the increase in plasma BDNF levels.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Maximilian Deest, Vanessa Buchholz, Kirsten Jahn, Christian Eberlein, Stefan Bleich, Helge Frieling
Summary: The methylation level of the MAOA promoter/exon 1 region is significantly lower in patients with Prader-Willi syndrome (PWS), especially in those experiencing temper outbursts, suggesting a dysregulation of methylation in the pathophysiology of PWS temper outbursts.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Christiane Muehle, Massimiliano Mazza, Christian Weinland, Claudia von Zimmermann, Patrick Bach, Falk Kiefer, Valery Grinevich, Iulia Zoicas, Johannes Kornhuber, Bernd Lenz
Summary: This study analyzed the OXTR serum concentrations in patients with AUD, finding a correlation between higher OXTR levels in male patients with alcohol-related readmissions. However, OXTR concentrations did not significantly differ between male and female patients with AUD and controls. The study also found lower OXTR concentrations in female smokers compared to non-smokers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Bernd Lenz, Sarah Gerhardt, Rafat Boroumand-Jazi, Anna Eichler, Verena Nadine Buchholz, Peter A. Fasching, Johannes Kornhuber, Tobias Banaschewski, Herta Flor, Stella Guldner, Maren Prignitz, Frauke Nees
Summary: Prenatal androgenization is associated with behavior and mental health in adolescence and adulthood. This study found that prenatal androgen load is related to frontal cortex volumes in a sex-dependent manner, with different effects in males and females. These findings contribute to our understanding of sex differences in behavior and mental health.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Bocwinska-Kiluk Beata, Jelski Wojciech, Kornhuber Johannes, Lewczuk Piotr, Mroczko Barbara
Summary: There is a lack of empirical research on non-pharmacological interventions for Alzheimer's disease (AD) globally. This paper examines the biochemical, clinical, and social aspects of AD in relation to psychological interventions and their impact on patients' quality of life. Despite limited research, psychological interventions based on biochemical and other studies show potential for improving emotional well-being and slowing disease progression in AD patients. However, no effective methods of AD treatment have been established to date.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
David Pericat, Stephen Adonai Leon-Icaza, Marina Sanchez Rico, Christiane Muehle, Iulia Zoicas, Fabian Schumacher, Remi Planes, Raoul Mazars, Germain Gros, Alexander Carpinteiro, Katrin Anne Becker, Jacques Izopet, Nathalie Strub-Wourgaft, Peter Sjoe, Olivier Neyrolles, Burkhard Kleuser, Frederic Limosin, Erich Gulbins, Johannes Kornhuber, Etienne Meunier, Nicolas Hoertel, Celine Cougoule
Summary: This study evaluated the potential antiviral and anti-inflammatory activities of fluoxetine in a SARS-CoV-2 infection model and in vitro. The results showed that fluoxetine significantly reduced lung tissue viral titers and expression of inflammatory markers, and inhibited the replication of all variants of concern. These effects may be attributed to the modulation of the ceramide system in the lung tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christiane Muehle, Johannes Kornhuber
Summary: The activity of neutral sphingomyelinase (NSM) has been detected in human serum and plasma samples, which hydrolyzes fluorescently labeled sphingomyelin to ceramide. This discovery could lead to the development of new biomarkers or therapeutic targets for diseases affected by sphingolipid derangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Christian P. Mueller, Gunter Schumann, Jurgen Rehm, Johannes Kornhuber, Bernd Lenz
Summary: Self-management includes behavioral measures and cognitive activities aimed at coping with challenges throughout the lifespan. Alcohol consumption has been used as a tool to support coping with specific problems during adolescence, adulthood, and aging. This systematic review provides evidence of non-addictive alcohol use for self-managing developmental issues and psychiatric symptoms, as well as the neuropharmacological effects of alcohol. Adverse effects and risks associated with alcohol use for self-management are discussed, and a new perspective is suggested to implement harm-controlled self-management with alcohol.
MOLECULAR PSYCHIATRY
(2023)
Article
Cell Biology
Iulia Zoicas, Christiane Muehle, Fabian Schumacher, Burkhard Kleuser, Johannes Kornhuber
Summary: Currently, there are no animal models available for studying specific social fear and social fear with comorbidities. This study investigated whether social fear conditioning (SFC), an animal model for social anxiety disorder (SAD), leads to comorbidities and how it affects brain sphingolipid metabolism. The results showed that SFC altered emotional behavior and brain sphingolipid metabolism in a time-dependent manner. Social fear alone did not cause changes in non-social anxiety or depressive behavior, but comorbid depression developed five weeks after SFC, accompanied by alterations in sphingolipid metabolism in various brain regions.
Article
Pediatrics
Stefan A. Mestermann, Peter A. W. Fasching, Matthias W. Beckmann, Jennifer Gerlach, Oliver H. Kratz, Gunther H. Moll, Johannes Kornhuber, Anna Eichler
Summary: Pregnancy anamnesis is crucial for child and adolescent psychiatry diagnostics. This study aimed to evaluate women's recall of prenatal events and found that retrospective self-reporting was not always accurate. The reliability of self-reporting on prenatal alcohol, smoking, partnership quality, pregnancy satisfaction, and obstetric complications varied.
Article
Clinical Neurology
Leonard P. Wenger, Oliver Hamm, Christiane Muehle, Sabine Hoffmann, Iris Reinhard, Patrick Bach, Johannes Kornhuber, Georg W. Alpers, Falk Kiefer, Tagrid Lemenager, Bernd Lenz
Summary: In this study, it was found that alcohol may affect trust in others not through modulation of oxytocin and androgens, but by inhibiting an increase in dihydrotestosterone. The study also confirmed the effects of alcohol on positive affect and risk-taking. These findings provide novel mechanistic insight into the influence of alcohol on social facilitation.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Eva-Maria Siegmann, Pauline Olm, Bernd Lenz, Christiane Muehle, Timo Jan Oberstein, Juan Manuel Maler, Johannes Kornhuber, Christopher M. William
Summary: This study examined the relationship between 2D:4D and the development and severity of AD. The results showed no significant association between 2D:4D and AD, but suggested a potential role of 2D:4D in depression in women.
Article
Chemistry, Medicinal
Nicolas Hoertel, Katayoun Rezaei, Marina Sanchez-Rico, Alfonso Delgado-Alvarez, Johannes Kornhuber, Erich Gulbins, Mark Olfson, Charles Ouazana-Vedrines, Alexander Carpinteiro, Celine Cougoule, Katrin Anne Becker, Jesus M. Alvarado, Frederic Limosin
Summary: The study suggests that the use of medications inhibiting acid sphingomyelinase (FIASMA) can reduce the risk of mortality in patients with SARS-CoV-2 infection. The multicenter retrospective observational study included 72,105 adult patients and found a significant association between FIASMA medication use and reduced 28-day mortality risk.
Article
Health Care Sciences & Services
Stefan Mestermann, Marie A. Arndt, Peter W. Fasching, Matthias Beckmann, Oliver H. Kratz, Gunther Moll, Johannes Kornhuber, Anna Eichler, IMAC Mind Consortium
Summary: This study analyzed paternal contributions to child well-being and found that father psychopathology significantly predicted girls' quality of life, while maternal parenting behavior had a significant influence on boys' quality of life. Fathers face different individual stressors and have different parenting behavior compared to mothers, but their influences are still significant, especially for daughters. Therefore, father-addressed pre- and intervention programs in child psychotherapeutic treatment are of high relevance.
Review
Psychology, Clinical
Monique L. Mefrouche, Eva-Maria Siegmann, Stephanie Boehme, Matthias Berking, Johannes Kornhuber
Summary: This study conducted a systematic review and meta-analysis to investigate the effects of digital-based mindfulness interventions on depressive, anxiety, and stress symptoms during pregnancy. The results indicated that digital mindfulness interventions were effective in reducing depression and anxiety symptoms, but had no significant effect on stress symptoms. The attrition rate and primiparity were found to moderate the intervention effect.
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
