Article
Psychiatry
Ester Anton-Galindo, Judit Cabana-Dominguez, Barbara Torrico, Roser Corominas, Bru Cormand, Noelia Fernandez-Castillo
Summary: This study demonstrates the pleiotropic contribution of dopaminergic and serotonergic genes to addiction and related behaviors, such as anxiety, irritability, neuroticism, and risk-taking behavior, highlighting the role of dopamine genes in the co-occurrence of these phenotypes.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Nutrition & Dietetics
Lucia Manfredi, Alessandra Accoto, Alessandro Couyoumdjian, David Conversi
Summary: This systematic review focuses on the genetic polymorphisms related to binge eating disorder (BED), highlighting potentially useful polymorphisms such as 5-HTTLPR, Taq1A, A118G, C957T, rs2283265, Val158Met, rs6198, Val103Ile, Ile251Leu, rs6265, and Leu72Met. Among these, Taq1A showed the most significant association with BED according to the research. Additional evidence is needed to confirm the impact of the other polymorphisms.
Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kishore K. Joshi, Tarmie L. Matlack, Stephanie Pyonteck, Mehul Vora, Ralph Menzel, Christopher Rongo
Summary: Metazoans utilize protein homeostasis pathways to respond to adverse conditions, with the nervous system playing a role in regulating proteostasis in different tissues. This study reveals that Caenorhabditis elegans uses biogenic amine neurotransmitters to modulate UPS proteostasis in epithelia by promoting eicosanoid production through P450 monooxygenases, ultimately maintaining protein turnover.
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Edenia C. Menezes, Relish Shah, Lindsay Laughlin, K. Yaragudri Vinod, John F. Smiley, Catarina Cunha, Andrea Balla, Henry Sershen, Francisco X. Castellanos, Andre Corvelo, Catia M. Teixeira
Summary: Early life is a critical period where enhanced neural plasticity allows the developing brain to adapt to its environment. Exposure to fluoxetine in early postnatal period can lead to reduced effort-related motivation and blunted dopaminergic activation in reward tasks in adulthood. Administering bupropion in adulthood can rescue the reduction in motivation, highlighting the involvement of the dopaminergic system in this process.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Saheed E. Elugoke, Omolola E. Fayemi, Abolanle S. Adekunle, Thabo T. Nkambule, Bhekie B. Mamba, Eno E. Ebenso
Summary: Nanodiamond is a type of carbon nanomaterial that can be used to detect neurotransmitters that provoke physiological responses, but there are limited electrochemical ND-based NT sensors available. The study focused on the performance of existing sensors, interactions between NTs and NDs, and the lack of data on the subject.
Article
Biochemical Research Methods
Rajasree G. Krishnan, Beena Saraswathyamma
Summary: This study presents a protocol for the simultaneous electroanalysis of tryptamine, serotonin, and dopamine using a conducting poly-murexide-based electrode, the first report of its kind. The analytes underwent irreversible electro-oxidation at the modified electrode surface under optimized conditions, with linear ranges for dopamine, serotonin, and tryptamine. The specificity of the developed electrode was satisfactory in the presence of other biomolecules, and electroanalysis was demonstrated in human serum for these targets.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Itaru Miura, Sho Horikoshi, Mizue Ichinose, Yuhei Suzuki, Kenya Watanabe
Summary: This review provides a comprehensive overview of the drug design, development, and therapy of lurasidone for schizophrenia treatment. Lurasidone has specific effects on different receptors and has been found to be effective in improving symptoms and preventing relapse in patients with schizophrenia. It also has minimal metabolic side effects and improves cognitive and functional performance.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Behavioral Sciences
Salar Vaseghi, Mohammad Nasehi, Mohammad-Reza Zarrindast
Summary: Cannabinoids interact with multiple neurotransmitters in learning and memory, yielding unpredictable effects, with mechanisms that require further investigation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Paul J. Fletcher, Zhaoxia Li, Xiaodong Ji, Guy A. Higgins, Douglas Funk
Summary: This study examined the effects of manipulating serotonin receptors on alcohol self-administration and alcohol-seeking behavior in rats. The results showed that blocking 5-HT2A receptors had limited effects on reducing alcohol-seeking, while activating 5-HT2C receptors had a broader range of effects on reducing alcohol self-administration, alcohol drinking, and alcohol-seeking behavior.
Article
Biochemistry & Molecular Biology
Tanya Scerbina, Robert Gerlai
Summary: This study investigates the effects of acute alcohol administration in zebrafish, suggesting that alcohol may influence behavior through dopaminergic mechanisms. Significant interactions and main effects of alcohol and D1-R antagonist are found on behavioral phenotypes and neurochemical levels, hinting at potential strain differences in identifying molecular mechanisms underlying acute alcohol effects.
Article
Clinical Neurology
Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Letter
Psychiatry
Blazej Misiak, Tomasz Bielawski, Jerzy Samochowiec, Agnieszka Samochowiec, Mariusz G. Fleszar, Paulina Fortuna, Bogna Kosyk, Dorota Frydecka
SCHIZOPHRENIA RESEARCH
(2023)
Article
Medicine, General & Internal
Anna Michalczyk, Ernest Tyburski, Piotr Podwalski, Katarzyna Waszczuk, Krzysztof Rudkowski, Jolanta Kucharska-Mazur, Monika Mak, Katarzyna Rek-Owodzin, Piotr Plichta, Maksymilian Bielecki, Wojciech Andrusewicz, Elzbieta Cecerska-Heryc, Agnieszka Samochowiec, Blazej Misiak, Leszek Sagan, Jerzy Samochowiec
Summary: Chronic subclinical inflammation is believed to play a role in schizophrenia. This study investigated the correlation between peripheral inflammatory markers (IM) levels and the integrity of brain regions in different stages of schizophrenia. The study did not find any correlations between IM levels and integrity of specific brain regions in schizophrenia spectrum disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Jerzy Samochowiec, Marcin Jablonski, Piotr Plichta, Patryk Piotrowski, Bartlomiej Stanczykiewicz, Tomasz Bielawski, Blazej Misiak
Summary: This study investigated the psychometric properties of the Self-evaluation of Negative Symptoms (SNS) in subjects with deficit subtype of schizophrenia (SCZ-D) and explored its usefulness in comparison with other clinical characteristics for screening SCZ-D. The results showed good internal consistency of SNS in both SCZ-D and non-deficit subtype (SCZ-ND) groups. SNS, PANSS, and SOFAS may serve as screening tools for SCZ-D.
Article
Nutrition & Dietetics
Anna Grzywacz, Arkadiusz Lubas, Stanislaw Niemczyk
Summary: This prospective observational study aimed to assess the nutritional status of type 1 and type 2 diabetes patients on dialysis and its relationship with hospitalizations and all-cause death. The results showed that type 1 diabetes patients had poorer nutritional status and higher nutritional risk compared to those with type 2 diabetes. Inferior nutritional status was associated with all-cause hospitalizations, while higher comorbidity was associated with a greater likelihood of cardiovascular hospitalizations and all-cause death.
Review
Microbiology
Agata Misera, Igor Loniewski, Joanna Palma, Monika Kulaszynska, Wiktoria Czarnecka, Mariusz Kaczmarczyk, Pawel Liskiewicz, Jerzy Samochowiec, Karolina Skonieczna-Zydecka
Summary: The relationship between drugs and microbiota is two-way. The proper composition and function of microbiota are key factors for some medications used in modern medicine. On the other hand, pharmacotherapeutic agents can significantly modify the microbiota, which in turn affects its function. A recent study revealed that nearly 25% of drugs administered to humans have antimicrobial effects. Multiple antidepressants have antimicrobial properties, and there are antibiotics with proven antidepressant effects. Additionally, antibiotics can cause mental phenotype changes, and some antibiotics have adverse effects including neurological and psychological symptoms, supporting the hypothesis that intestinal microbiota may affect the function of the central nervous system. We have comprehensively collected data on psychiatric drugs and their antimicrobial properties, which we believe has strong implications for the treatment of psychiatric entities. However, our study also highlights the need for more well-designed trials to analyze the function of gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Clinical Neurology
Aleksandra Kroll, Ewa Danczura, Piotr Podwalski, Jolanta Kucharska-Mazur, Monika Mak
Summary: There is a need for objective and efficient methods to diagnose cognition in depression. In this study, we developed a set of simple visual tasks with three different speed measuring approaches: paper-pencil, computer-based, and eye-tracking. We examined 11 patients with major depression twice (before and after three months of medication) along with a control group of healthy individuals. Cognitive difficulties were observed in all tasks, and while there was some improvement after medication, it did not reach the level of the control group. These observed difficulties could be linked to psychomotor retardation, a common symptom in depression, as indicated by differences in reaction times and saccade latencies. Analyzing simple visual reaction times could be a promising method to measure cognitive state and recovery in individuals with mood disorders and major depressive disorder treatment.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Medicine, General & Internal
Maksymilian Bielecki, Ernest Tyburski, Piotr Plichta, Monika Mak, Jolanta Kucharska-Mazur, Piotr Podwalski, Katarzyna Rek-Owodzin, Katarzyna Waszczuk, Leszek Sagan, Shane T. Mueller, Anna Michalczyk, Blazej Misiak, Jerzy Samochowiec
Summary: This study compared executive functions between deficit and non-deficit schizophrenia patients and healthy controls, while controlling for IQ and level of education. It also compared executive functions within the two patient groups, while controlling for IQ and psychopathological symptoms. Relationships between clinical factors, psychopathological symptoms, and executive functions were estimated using structural equation modeling. Results showed that both patient groups performed poorer on cognitive flexibility compared to healthy controls, with deficit schizophrenia patients performing worse on verbal working memory and non-deficit schizophrenia patients performing worse on planning. After controlling for IQ and negative symptoms, there were no differences in executive functions between deficit and non-deficit schizophrenia patients, except for planning. Clinical variables appeared to significantly impact these deficits.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Piotr Plichta, Ernest Tyburski, Maksymilian Bielecki, Monika Mak, Jolanta Kucharska-Mazur, Piotr Podwalski, Katarzyna Rek-Owodzin, Katarzyna Waszczuk, Leszek Sagan, Anna Michalczyk, Blazej Misiak, Jerzy Samochowiec
Summary: This study compared cognitive domains between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS) patients and healthy controls (HC), analyzing relationships between psychopathological dimensions and cognitive domains. The results showed that clinical groups performed poorer than HC groups in various cognitive domains, and DS patients scored poorer than NDS patients in all cognitive domains except for reasoning and problem solving. Psychopathological symptoms were only related to cognitive functions in NDS patients. The findings suggest that the MCCB battery is sensitive to detecting cognitive dysfunctions in both deficit and non-deficit schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Krzysztof Rudkowski, Katarzyna Waszczuk, Ernest Tyburski, Katarzyna Rek-Owodzin, Piotr Plichta, Piotr Podwalski, Maksymilian Bielecki, Monika Mak, Anna Michalczyk, Maciej Tarnowski, Katarzyna Sielatycka, Marta Budkowska, Karolina Luczkowska, Barbara Dolegowska, Mariusz Z. Z. Ratajczak, Jerzy Samochowiec, Jolanta Kucharska-Mazur, Leszek Sagan
Summary: Evidence suggests a role of the immune system in mental conditions like schizophrenia. The complement cascade (CC), a critical element of regeneration processes, may be involved. This study found elevated levels of complement activation products in chronic schizophrenia patients, particularly C3a and C5a, which showed significant correlations with the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Tomasz Pawlowski, Krzysztof Malyszczak, Dariusz Pawlak, Malgorzata Inglot, Malgorzata Zalewska, Anna Grzywacz, Marek Radkowski, Tomasz Laskus, Justyna Janocha-Litwin, Dorota Frydecka
Summary: The aim of this study was to explore the associations between serotonin gene polymorphisms and tryptophan catabolite concentration during PEG-IFN-alpha 2a treatment, as well as the associations between polymorphisms within HTR1A, TPH2, and 5-HTT genes and the severity of depression symptoms. The study found that subjects with C/C genotypes of 5-HT1A and lower-expressing alleles of 5-HTTLPR had higher total depression scores and greater increase in depression scores during treatment. Associations between tryptophan concentrations and TPH-2 and 5-HTTLPR rs25531 genotypes were also observed.
Article
Endocrinology & Metabolism
Pawel Karpinski, Paulina Zebrowska-Rozanska, Dorota Kujawa, Lukasz Laczmanski, Jerzy Samochowiec, Marcin Jablonski, Piotr Plichta, Patryk Piotrowski, Tomasz Bielawski, Blazej Misiak
Summary: This study aimed to compare gut microbiota between patients with schizophrenia and controls, taking into consideration factors such as exposure stress, dietary habits, metabolic parameters, and clinical manifestation. The results showed increased abundance of Lactobacillus and Limosilactobacillus and decreased abundance of Faecalibacterium and Paraprevotella in patients with schizophrenia. Machine learning analysis revealed that these gut microbiota differences were associated with factors such as psychosocial stress, poor nutrition, lipid profile alterations, and cognitive impairment.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Agnieszka Cyran, Edyta Pawlak, Patryk Piotrowski, Tomasz Bielawski, Jerzy Samochowiec, Ernest Tyburski, Magdalena Chec, Krzysztof Rembacz, Lukasz Laczmanski, Wiktoria Bieniek, Andrzej Gamian, Blazej Misiak
Summary: There is evidence that subclinical inflammation and increased gut permeability might be involved in the pathophysiology of schizophrenia. However, the present study found that individuals with deficit subtype of schizophrenia (D-SCZ) show higher levels of immune-inflammatory markers, but no significant difference in gut permeability marker (zonulin) compared to non-deficit schizophrenia (ND-SCZ) and healthy controls (HCs).
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Julia Eder, Geert Dom, Philip Gorwood, Hikka Kaerkkaeinen, Andre Decraene, Ulrike Kumpf, Julian Beezhold, Jerzy Samochowiec, Tamas Kurimay, Wolfgang Gaebel, Livia De Picker, Peter Falkai
Summary: The European Psychiatric Association has proposed a policy paper addressing the unmet healthcare and research needs of patients with depressive disorders. They emphasize the importance of increased awareness, development of new biomarkers, implementation of machine learning technology, use of electronic devices and apps for treatment, development of new treatment options, and comprehensive recovery approach. They also propose priorities at a political level regarding open science, data protection laws, ethical electronic health records, and better healthcare research and resource-saving.
EUROPEAN PSYCHIATRY
(2023)
Review
Psychiatry
Blazej Misiak, Jerzy Samochowiec, Krzysztof Kowalski, Wolfgang Gaebel, Claudio L. A. Bassetti, Andrew Chan, Philip Gorwood, Sergi Papiol, Geert Dom, Umberto Volpe, Agata Szulc, Tamas Kurimay, Hilkka Karkkainen, Andre Decraene, Jan Wisse, Andrea Fiorillo, Peter Falkai
Summary: The ongoing developments in psychiatric classification systems have improved the reliability of diagnosis for schizophrenia to some extent, but due to unknown pathophysiology and lack of biomarkers, its validity still remains low, requiring further advancements. In contrast, multiple sclerosis, with its established pathophysiology and defined biomarkers, has good validity and improved treatment options. Recognizing the clinical heterogeneity of schizophrenia and considering the similarities it shares with multiple sclerosis, it is crucial to deconstruct the psychosis spectrum and adopt dimensional approaches to refine current diagnostic boundaries.
EUROPEAN PSYCHIATRY
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)