Article
Pharmacology & Pharmacy
Ruo Man Wu, Chun Yan Wang, Jie Wang, Xiao Le Xu
Summary: This study found that paeoniflorin has potential therapeutic value for atherosclerosis by promoting reverse cholesterol transport (RCT) and inhibiting inflammation. It reduced atherosclerosis, improved hyperlipidemia, and mitigated hepatic steatosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Vasily A. Kudinov, Tatiana I. Torkhovskaya, Tamara S. Zakharova, Galina E. Morozevich, Rafael I. Artyushev, Marina Yu. Zubareva, Sergey S. Markin
Summary: The study demonstrates that lipidating HDL with phospholipid nanoparticles can improve HDL functionality, enhance cholesterol efflux capacity, and provide protection against atherosclerosis progression.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Cheng Zhang, Xuewen Wu, Pengmin Shi, Hongyu Ma, Fei Fang, Qianlang Feng, Shuang Zhao, Ruipu Zhang, Jinyuan Huang, Xinting Xu, Weilie Xiao, Guang Cao, Xu Ji
Summary: In this study, it was found that diterpenoids from the traditional Chinese medicine Callicarpa rubella could effectively inhibit oxidized low-density lipoprotein-induced macrophage foam cell formation by promoting cholesterol efflux, suggesting their potential as drugs for the treatment of atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laeticia Scherler, Sofia N. Verouti, Daniel Ackermann, Bruno Vogt, Genevieve Escher
Summary: In this study, adenine was used to induce nephropathy in mice, showing the loss of protective effects of renal cholesterol and vitamin D-3 metabolism under this condition. It was found that adenine enhanced cholesterol efflux and eliminated lipids in feces, which had a protective effect against atherosclerosis but also affected bone growth.
Article
Biochemistry & Molecular Biology
Ilaria Zanotti, Francesco Poti, Marina Cuchel
Summary: HDL plays an antiatherogenic role by accepting cholesterol from cells and promoting reverse cholesterol transport, with cholesterol efflux capacity being associated with cardiovascular risk in various human cohorts. These findings support the protective role of RCT in humans.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Nutrition & Dietetics
Malgorzata Sidorkiewicz
Summary: The maintenance of cholesterol homeostasis involves complicated processes such as regulation of cholesterol synthesis, dietary uptake, and bile acid synthesis and excretion. Reverse cholesterol transport, mediated by high-density lipoproteins, plays a vital role in transferring cholesterol from non-hepatic cells to the liver for excretion. MicroRNA-33 has been identified as a key regulator of cholesterol homeostasis, impacting both cellular cholesterol efflux and bile metabolism in the liver. Understanding these mechanisms could lead to new perspectives in microRNA-targeted treatment for cholesterol imbalance.
Article
Biochemistry & Molecular Biology
Shamil Akhmedov, Sergey Afanasyev, Natalia Beshchasna, Marina Trusova, Ivan Stepanov, Mariya Rebenkova, Ekaterina Poletykina, Yuri Vecherskiy, Sergei Tverdokhlebov, Evgeny Bolbasov, Sascha Balakin, Joerg Opitz, Anatoly Yermakov, Boris Kozlov
Summary: The interaction of chemically modified carbon-coated iron nanoparticles (Fe@C NPs) with subcutaneous fat tissue in rats and human atherosclerotic plaques was studied. The results showed the potential of these nanoparticles in inhibiting and destroying atherosclerotic plaques, which is important for the fabrication of vascular stents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Ali Ahmadi, Mariam Bagheri Ekta, Amirhossein Sahebkar
Summary: This review summarizes the potential effects of hypoglycemic agents on cholesterol efflux (CE), a key step in reverse cholesterol transport (RCT), and how this may influence atherosclerosis and fatty liver disease. Newer antidiabetic agents have the potential to target CE and prevent or alleviate the development of related diseases, while also improving insulin secretion. However, further research is needed to interpret the clinical relevance of these findings.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Vasily P. Karagodin, Volha I. Summerhill, Shaw-Fang Yet, Alexander N. Orekhov
Summary: This review discusses the potential role and mechanisms of plant-derived polysaccharides in the treatment of atherosclerosis, and explores directions for further research.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Biochemistry & Molecular Biology
Wei-Hua Tan, Zheng-Liang Peng, Ting You, Zhi-Lu Sun
Summary: The study demonstrated that CTRP15 inhibits the development of atherosclerosis by enhancing RCT efficiency and increasing plasma HDL-C levels through the T-cadherin/miR-101-3p/ABCA1 pathway. Targeting CTRP15 may serve as a novel and promising therapeutic strategy for atherosclerotic cardiovascular diseases.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhezhe Chen, Qiongjun Zhu, Duanbin Li, Qingbo Lv, Guosheng Fu, Boxuan Ma, Wenbin Zhang
Summary: In this study, a targeting nanoplatform named LPLCH is constructed to perform a dual-track reverse cholesterol transport strategy for the inhibition and degradation of atherosclerosis. LPLCH exhibits active targeting ability to plaques, efficient internalization by foam cells, and escape from lysosomes through pH-triggered charge conversion. Additionally, the nanoparticles carry deposited cholesterol crystals and activate cholesterol efflux, providing a potential candidate for the effective therapy of early-stage atherosclerosis.
Article
Biochemistry & Molecular Biology
Shamil Akhmedov, Sergey Afanasyev, Marina Trusova, Pavel Postnikov, Yulia Rogovskaya, Elena Grakova, Kristina Kopeva, Rosa Karen Carreon Paz, Sascha Balakin, Hans-Peter Wiesmann, Joerg Opitz, Benjamin Kruppke, Natalia Beshchasna, Sergey Popov
Summary: The novel Fe@C NPs show great potential in the treatment of atherosclerosis by causing structural changes in plaques. They exhibit high biocompatibility in in vitro experiments and rat studies, indicating a promising role as active substances in stent coatings.
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Dmitry A. Kashirskikh, Vasily N. Sukhorukov, Vladislav Kalmykov, Andrey V. Omelchenko, Alexander N. Orekhov
Summary: Atherosclerosis is a major cause of serious cardiovascular disorders, and its pathogenesis involves multiple processes. Reverse transport of cholesterol is a mechanism that plays a protective role against atherosclerosis. Disordered cholesterol metabolism can result in dyslipidemia and early atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Magdalena Wit, Jonathan Trujillo-Viera, Akim Strohmeyer, Martin Klingenspor, Mohammed Hankir, Grzegorz Sumara
Summary: Overconsumption of energy-dense foods can lead to increased intestinal nutrient absorption and excessive lipid accumulation, resulting in obesity and obesity-associated diseases. Targeting the pathways that regulate intestinal nutrient absorption holds significant therapeutic potential.
EMBO MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Miguel Hueso, Raquel Grinan, Adrian Mallen, Estanislao Navarro, Elvira Purqueras, Montse Goma, Fabrizio Sbraga, Arnau Blasco-Lucas, Giovanna Revilla, David Santos, Marina Canyelles, Josep Julve, Joan Carles Escola-Gil, Noemi Rotllan
Summary: miR-125b regulates cholesterol efflux by downregulating SCARB1 and SR-B1 in human and mouse macrophages as well as VSMCs, impairing macrophage cholesterol efflux in vitro and the macrophage-specific reverse cholesterol transport pathway in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Francisco Blanco-Vaca, Noemi Rotllan, Marina Canyelles, Didac Mauricio, Joan Carles Escola-Gil, Josep Julve
Summary: NAD+-increasing strategies have shown potential in improving cardiometabolic health, with various forms of vitamin B3 being tested in clinical trials. These interventions have demonstrated positive effects on exercise capacity, blood pressure, anti-inflammatory profile, insulin-stimulated glucose disposal, and fat-free mass.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Estefania Nunez, Valentin Fuster, Maria Gomez-Serrano, Jose Manuel Valdivielso, Juan Miguel Fernandez-Alvira, Diego Martinez-Lopez, Jose Manuel Rodriguez, Elena Bonzon-Kulichenko, Enrique Calvo, Alvaro Alfayate, Marcelino Bermudez-Lopez, Joan Carles Escola-Gil, Leticia Fernandez-Friera, Isabel Cerro-Pardo, Jose Maria Mendiguren, Fatima Sanchez-Cabo, Javier Sanz, Jose Maria Ordovas, Luis Miguel Blanco-Colio, Jose Manuel Garcia-Ruiz, Borja Ibanez, Enrique Lara-Pezzi, Antonio Fernandez-Ortiz, Jose Luis Martin-Ventura, Jesus Vazquez
Summary: This study identified circulating proteins that are associated with subclinical atherosclerosis and can predict the disease. These proteins offer potential for improving primary prevention strategies in areas where cardiovascular imaging is not available.
Review
Cardiac & Cardiovascular Systems
Miriam Lee-Rueckert, Jani Lappalainen, Petri T. Kovanen, Joan Carles Escola-Gil
Summary: Macrophages play important roles in atherosclerosis and malignant tumors, showing phenotypic and functional plasticity in response to different microenvironments. In atherosclerosis, macrophages form foam cells, which have anti-atherogenic effects. In malignant tumors, macrophages can exhibit either anti-tumoral or pro-tumoral characteristics, but their specific roles are still poorly understood.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Carla Borras, Aina Mercer, Sonia Sirisi, Daniel Alcolea, Joan Carles Escola-Gil, Francisco Blanco-Vaca, Mireia Tondo
Summary: This work aims to review the mechanisms of high-density lipoprotein (HDL)-mediated cholesterol trafficking in the central nervous system (CNS) in the context of Alzheimer's disease (AD). It explores the relationship between HDL-mediated cholesterol transport and Aβ peptide accumulation and apolipoprotein E (ApoE)-mediated cholesterol transport. The existing data suggest decreased cholesterol efflux and impaired cholesterol entry into neurons among patients with AD. However, most studies in this field have been performed in cells that are not physiologically relevant for CNS pathology, which is a major flaw. Further investigations are needed to clarify the role of cholesterol trafficking in AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marta Farras, Jonathan Richard Swann, Ian Rowland, Laura Rubio, Isaac Subirana, Ursula Catalan, Maria Jose Motilva, Rosa Sola, Maria Isabel Covas, Francisco Blanco-Vaca, Montserrat Fito, Jordi Mayneris-Perxachs
Summary: The consumption of phenol-rich oils, such as virgin olive oil, has been shown to have beneficial effects on cardiovascular health. This study aimed to explore the broader biochemical impact of phenol-enriched olive oils. The results showed that both interventions with phenol-enriched olive oils led to a favorable shift in the circulating metabolic phenotype, reducing metabolites associated with cardiometabolic diseases.
Review
Biochemistry & Molecular Biology
Marina Canyelles, Carla Borras, Noemi Rotllan, Mireia Tondo, Joan Carles Escola-Gil, Francisco Blanco-Vaca
Summary: Trimethylamine-N-oxide (TMAO), the main metabolite produced by gut microbiota, is mainly eliminated through renal excretion. Elevated levels of TMAO have been associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) and related complications. However, the causal relationship between TMAO and CVD remains inconclusive, with conflicting findings in prospective studies and potential mediating role of renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Marina Canyelles, Antonio Perez, Alexandra Junza, Inka Minambres, Oscar Yanes, Helena Sarda, Noemi Rotllan, Josep Julve, Jose Luis Sanchez-Quesada, Mireia Tondo, Joan Carles Escola-Gil, Francisco Blanco-Vaca
Summary: This study evaluated the effects of glycemic control and bariatric surgery on TMAO and γ BB in newly diagnosed T2D patients and morbidly obese subjects, showing that neither glycemic control nor bariatric surgery improved the circulating concentrations of TMAO in these populations.
Article
Biochemistry & Molecular Biology
Juan Pablo Munoz, Paula Sanchez-Fernandez-de-Landa, Elena Maria Goretti Diarte-Anazco, Antonio Zorzano, Francisco Blanco-Vaca, Josep Julve
Summary: FTY720 is an FDA-approved drug used in the treatment of multiple sclerosis, and it has been found to have additional benefits in glucose metabolism, metabolic diseases, and cardiac ischemia. The active form of FTY720, FTY720-P, activates mitochondrial respiration and ATP production in human cardiomyocyte cells. It also affects mitochondrial nucleoids, morphology, and activates the transcription factor STAT3, which promotes mitochondrial function. These effects are suppressed in the presence of a STAT3 inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lasse Sprankel, David Vizarraga, Jesus Martin, Sina Manger, Jakob Meier-Credo, Marina Marcos, Josep Julve, Noemi Rotllan, Margot P. Scheffer, Joan Carles Escola-Gil, Julian D. Langer, Jaume Pinol, Ignacio Fita, Achilleas S. Frangakis
Summary: This study reveals the structural and functional analysis of the previously uncharacterized protein P116. P116 plays a crucial role in extracting essential lipids from the host environment, offering a potential target for controlling Mycoplasma infection.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Madalina Nicoleta Nan, Alvaro Garcia-Osuna, Josefina Mora, Cristina Trilla, Assumpta Antonijuan, Vanesa Orantes, Monica Cruz-Lemini, Francisco Blanco-Vaca, Elisa Llurba
Summary: Algorithms for first-trimester prediction of pre-eclampsia lack sensitivity for predicting late-onset pre-eclampsia and other placental complications. This study aimed to assess the screening performance of biomarkers in the prediction of adverse obstetric outcomes related to placental insufficiency. PlGF, sFlt-1, NT-proBNP, and uric acid measurements combined with maternal factors improved the prediction of complications.
Article
Biochemistry & Molecular Biology
Giovanna Revilla, Nuseibah Al Qtaish, Pablo Caruana, Myriam Sainz-Ramos, Tania Lopez-Mendez, Francisco Rodriguez, Veronica Paez-Espinosa, Changda Li, Nuria Fucui Vallverdu, Maria Edwards, Antonio Moral, Jose Ignacio Perez, Juan Carlos Escola-Gil, Jose Luis Pedraz, Idoia Gallego, Rosa Corcoy, Maria Virtudes Cespedes, Gustavo Puras, Eugenia Mato
Summary: This study produced and assessed lenvatinib-loaded PLGA nanoparticles (NPs) as a novel therapeutic approach for aggressive thyroid tumors. The decorated NPs showed better cytotoxicity and therapeutic efficacy in vitro and in vivo compared to NPs without decoration, suggesting a promising strategy for targeted and effective administration of TKIs.
Article
Food Science & Technology
Maria-Carmen Lopez de las Hazas, Andrea del Saz-Lara, Lidia Cedo, Maria Carmen Crespo, Joao Tome-Carneiro, Luis A. Chapado, Alba Macia, Francesco Visioli, Joan C. Escola-Gil, Alberto Davalos
Summary: HT supplementation in humanized mice resulted in systemic dyslipidemia, impaired glucose metabolism, increased body weight, and accumulation of triacylglycerols in different tissues. The expression of genes related to lipid metabolism, such as Pltp or Lpl, was also modulated by HT. Further studies are needed to fully understand the potential effects of HT consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
R. Grinan, M. Hueso, A. Mallen, E. Navarro, E. Purqueras, M. Goma, F. Sbraga, A. Blasco-Lucas, G. Revilla, D. Santos, M. Canyelles, J. Julve, J. C. Escola, N. Rotllan
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)