Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 106, Issue 2, Pages 410-413Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2011.03.002
Keywords
Bioinformatics; Microarrays; Reverse engineering; Receiver operating characteristic curves
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Funding
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
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Systems biology uses systems of mathematical rules and formulas to study complex biological phenomena. In cancer research there are three distinct threads in systems biology research: modeling biology or biophysics with the goal of establishing plausibility or obtaining insights, modeling based on statistics, bioinformatics, and reverse engineering with the goal of better characterizing the system, and modeling with the goal of clinical predictions. Using illustrative examples we discuss these threads in the context of cancer research. Published by Elsevier Ltd.
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