Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Qian Zhao, Aisheng Dong, Yushu Bai, Changjing Zuo
Summary: This article reports the PSMA PET findings of mixed ductal-acinar adenocarcinoma of the prostate. The case shows multiple lymph node and bone metastases. The primary tumor displayed heterogeneous PSMA uptake, while the metastases in the right ilium and acetabulum exhibited intense PSMA uptake, but there was no significant PSMA uptake in the pelvic lymph node and left iliac bone metastases. Understanding the intraprimary and intermetastatic heterogeneity of PSMA uptake in mixed ductal-acinar adenocarcinoma of the prostate may aid in accurate interpretation.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Feng Li, Suokai Zhai, Li Fu, Lin Yang, Yousheng Mao
Summary: This study aimed to develop nomograms for intraoperative prediction of lymph node metastasis in early-stage lung adenocarcinoma. The nomograms showed good discriminatory performance in predicting lymph node metastasis and N2 lymph node metastasis. Additionally, it was found that there were survival outcome differences between systematic mediastinal lymphadenectomy and limited mediastinal lymphadenectomy for high-risk patients.
Article
Surgery
Emily Papai, Avinoam Nevler, Charalambos Solomides, Mandeep S. Shergill, Theresa P. Yeo, Shawnna Cannaday, Charles J. Yeo, Jordan M. Winter, Harish Lavu
Summary: Cytologic sampling from ex vivo specimen irrigation after surgical resection of pancreatic and periampullary adenocarcinoma may have implications for locoregional recurrence, survival, and treatment.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Oncology
Zihao Wang, Yaning Wang, Mengqi Chang, Yuekun Wang, Peng Liu, Jianqiang Wu, Guige Wang, Xiaoyue Tang, Xiangyi Hui, Penghao Liu, Xiaopeng Guo, Bing Xing, Yu Wang, Zhijun Han, Wenbin Ma
Summary: This study identified the cellular origins and drivers of brain metastasis from lung adenocarcinoma (LUAD) at a single-cell level and developed a BM-index to indicate the risk of brain metastasis. They discovered brain metastasis-associated epithelial cells and their biomarker, and predicted therapeutic drugs targeting these cells. This study lays a foundation for early detection of high-risk LUAD patients.
Article
Biochemistry & Molecular Biology
Sina Chen, Shunheng Zhou, Yu-e Huang, Mengqin Yuan, Wanyue Lei, Jiahao Chen, Kongxuan Lin, Wei Jiang
Summary: In this study, a method called scMetR was proposed to evaluate the metastatic risk of PDAC patients based on single-cell RNA sequencing data. The study found that tumor cells with metastatic features play an important role in disease progression, and metastasis-associated genes are up-regulated in these cells. Additionally, the study predicted candidate drugs that may reverse the expression of these metastasis-associated genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Maria Leticia de Almeida Lanca, Yasmin Rodarte Carvalho, Janete Dias Almeida, Estela Kaminagakura
Summary: This case report describes a rare case of metastatic colon adenocarcinoma to the maxilla, with only the second case reported in the palate. A literature review revealed 45 clinical cases of colon adenocarcinoma with metastasis to the oral cavity.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Letter
Oncology
Jianing Chen, Hainan Yang, Chao Zhao, Tao Lin, Da Liu, Weiping Hong, Changguo Shan, Cheng Zhou, Ling Bao, Caicun Zhou, Linbo Cai, Chunxia Su, Zhaoming Zhou, Lei Wen
Summary: Brain metastasis is a major cause of cancer-related death. Some patients are diagnosed with brain metastases at their first visit without prior treatment, while others develop brain metastases during systemic therapies. The genomic differences between these two groups are unclear. In this study, we analyzed the genomic features of synchronous and metachronous brain metastases in lung adenocarcinoma patients using panel-targeted gene sequencing of cerebrospinal fluid and plasma samples. CSF liquid biopsies were found to be superior in detecting gene alterations. EGFR and TP53 were the most frequently altered genes in both groups, but with different exon point mutations. The RTK-RAS and TP53 pathways were identified as the most affected pathways.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Yuhao Luo, Kelin Mou, Jianmei Wang, Jing Luo, Lin Peng, Hua Ye, Sheng Lin
Summary: This report describes a rare case of colon metastasis in a patient with lung adenocarcinoma. The patient developed abdominal symptoms after immunotherapy and chemotherapy, and subsequent PET-CT scans confirmed multiple lymph node, pleural, and adrenal metastases. Molecular detection revealed BRAF V600E mutation and high PD-L1 expression. Despite initial reduction in lymph nodes with first-line immunotherapy, the patient experienced colon obstruction and bone metastasis. Colon resection confirmed metastasis from lung adenocarcinoma. Palliative radiotherapy and second-line therapy were administered. The paper discusses the clinical characteristics, pathology, imaging, molecular profile assessments, and treatment of primary lung adenocarcinoma with colon metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Long Xu, Hang Su, Shengnan Zhao, Haojie Si, Huikang Xie, Yijiu Ren, Jiani Gao, Fang Wang, Xiaofeng Xie, Chenyang Dai, Chunyan Wu, Deping Zhao, Chang Chen
Summary: A new method using semi-dry dot-blot (SDB) to detect micropapillary (MIP) component in lung adenocarcinoma (LUAD) surgery was developed. Differential protein expression analysis identified cellular retinoic acid-binding protein 2 (CRABP2) as significantly upregulated in MIP-positive LUAD. The SDB method accurately detected MIP component using CRABP2 visualization, comparable to a pathologist's performance.
BRITISH JOURNAL OF CANCER
(2023)
Article
Urology & Nephrology
Carlo A. Bravi, Giuseppe Rosiello, Giuseppe Fallara, Emily Vertosick, Amy Tin, Daniel Sjoberg, Marco Bianchi, Elio Mazzone, Alberto Martini, Paolo Dell'oglio, Armando Stabile, Giorgio Gandaglia, Nicola Fossati, Alberto Briganti, Francesco Montorsi, Andrew Vickers
Summary: The neutrophil-to-lymphocyte ratio does not have clinical utility for predicting adverse pathology and biochemical recurrence in localized prostate cancer patients undergoing radical prostatectomy. Further research should focus on its value for predicting regional lymph node metastasis.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Oncology
Oluwaseun B. Ogunbona, Abigail L. Goodman, Adeboye O. Osunkoya
Summary: A study identified 30 cases of metastatic prostatic adenocarcinoma to the brain and spinal cord, with most cases presenting as a solitary mass in the temporal lobe and thoracic region. The majority of patients had metastases in other organs as well, with some cases having brain or spinal cord metastasis as the initial diagnosis of PCa. Follow-up data was available for 21 cases, with a mean duration of 20 months.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2021)
Article
Endocrinology & Metabolism
Yu G. Tan, Farhan Khalid, Hong H. Huang, Kenneth Chen, Kae J. Tay, Weber K. O. Lau, Christopher W. S. Cheng, Nye T. Ngo, John S. P. Yuen
Summary: In this study, it was found that patients with prostatic ductal adenocarcinoma (PDA) tended to be older, have higher PSA levels, and exhibit more aggressive pathological features, which independently predicted poorer oncological outcomes after radical prostatectomy.
Article
Clinical Neurology
Servet Inci, Dicle Karakaya
Summary: The study examined the risk factors for intraoperative rupture (IOR) and the role of surgical experience. Surgical experience was found to reduce the IOR rate from 10%-11% to 4%-5% after an average of 250 aneurysm operations, but did not decrease further with more experience. This study presents a learning curve for IOR for the first time in the literature.
WORLD NEUROSURGERY
(2021)
Article
Cell Biology
Xin Ji, Zihao Wang, Guige Wang, Lijun Tang, Zhijun Han
Summary: Lymph node metastasis (LNM) is a common pathway in lung adenocarcinoma (LUAD) and is associated with a poor prognosis and higher recurrence risk. Discovering drivers and targets of LNM is crucial for early detection of high-risk patients and guiding personalized therapy.
Article
Oncology
Bogdan Badic, Marie Morvan, Lucille Queneherve, Servane Bouzeloc, Tiphaine Kermarrec, Jean-Baptiste Nousbaum, Noemi Reboux
Summary: Pancreatic cancer is a deadly digestive cancer, and its incidence has been increasing in recent decades. A retrospective study analyzed data from 2117 patients in a digestive tumor registry and identified prognostic factors for survival, including age, surgery, chemotherapy, radiotherapy, and metastasis location. The study provides valuable insights into the management and treatment options for pancreatic cancer.
