Article
Cell Biology
Dan Luo, Chune Yu, Jing Yu, Chao Su, Shun Li, Peng Liang
Summary: Killin has been found to play a role in p53-mediated G1 arrest by upregulating p21 protein expression independently of p53. Knockout of Killin significantly decreases p53-mediated G1 arrest, and double knockout of Killin and p21 completely abolishes this arrest. These findings suggest that Killin is involved in multiple cell cycle checkpoint controls, including p53-mediated G1 arrest.
Article
Chemistry, Multidisciplinary
Xiuyan Wan, Teng Zheng, Dawei Wang, Wei Pan, Yanan Gao, Na Li, Bo Tang
Summary: A porphyrin-based material with covalent organic framework (COF) was developed as a nitric oxide (NO) donor delivery nanoplatform responsive to glutathione for synergistic cancer therapy involving NO mediated therapy and photodynamic therapy.
CHEMICAL COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Gizem Kayki-Mutlu, Walter J. Koch
Summary: Cardiac diseases, especially heart failure, are the leading cause of morbidity and mortality globally. The loss of beta-adrenoceptor-mediated inotropic reserve and the elevated activities of G protein-coupled receptor kinases and beta-arrestins after heart injury/stress play significant roles in heart failure. Nitric oxide produced by NO synthase enzymes modulates GPCR regulators profoundly through S-nitrosylation, independent of its canonical signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yuan Wang, Huazhang Wu, Nannan Dong, Xu Su, Mingxiu Duan, Yaqin Wei, Jun Wei, Gaofeng Liu, Qingjie Peng, Yunli Zhao
Summary: The study demonstrated that SFN impairs colony-forming ability in GC cells, suppresses cell proliferation by arresting cell cycle at S phase, enhances cell apoptosis, and upregulates p53, p21 while downregulating CDK2 expression, suggesting a potential therapeutic application of SFN in GC treatment and prevention.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Christopher H. Switzer, Hyun-Ju Cho, Thomas R. Eykyn, Paul Lavender, Philip Eaton
Summary: Inducible nitric oxide synthase (NOS2) and nitric oxide (NO) signaling lead to DNA hypomethylation and genomic instability through degradation of DNMT1 protein and retrotransposon activation. NOS2 expression levels are correlated with decreased DNA methylation and malignant cellular transformation in breast cancer patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Divya Seth, Colin T. Stomberski, Precious J. McLaughlin, Richard T. Premont, Kathleen Lundberg, Jonathan S. Stamler
Summary: The aim of this study was to investigate the interactions between nitric oxide synthase (NOS) isoforms and proteins, as well as the mechanisms by which they mediate S-nitrosylation. The results showed that each NOS isoform interacts with and S-nitrosylates many proteins, but a large proportion of S-nitrosylated proteins are not associated with NOS. Additionally, the interactomes and S-nitrosylomes of individual NOS isoforms are largely unique, indicating specific roles for each isoform in S-nitrosylation.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Multidisciplinary Sciences
Meng-Lin Chao, Shanshan Luo, Chao Zhang, Xuechun Zhou, Miao Zhou, Junyan Wang, Chuiyu Kong, Jiyu Chen, Zhe Lin, Xin Tang, Shixiu Sun, Xinlong Tang, Hongshan Chen, Hong Wang, Dongjin Wang, Jin-Peng Sun, Yi Han, Liping Xie, Yong Ji
Summary: The study demonstrates that S-nitrosylation of GNAI2 drives the development of atherosclerosis in diabetic patients by coupling with CXCR5 and activating YAP, leading to endothelial inflammation. Additionally, reducing SNO-GNAI2 is an effective strategy for alleviating diabetes-accelerated atherosclerosis.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Venkateshwar Madka, Jagan M. R. Patlolla, Karthikkumar Venkatachalam, Yuting Zhang, Gopal Pathuri, Nicole Stratton, Stanley Lightfoot, Naveena B. Janakiram, Altaf Mohammed, Chinthalapally V. Rao
Summary: Colon cancer is a significant health problem that is increasing in occurrence, especially among young adults. Previous studies have shown promising preventive effects of drugs like Sulindac and DFMO, but long-term use at high doses can cause side effects. This study explores alternative strategies for preventing colon cancer using low-dose combinations of these drugs, as well as testing the efficacy of Sulindac derivatives. The results suggest that these treatment regimens can effectively inhibit tumor progression without causing toxicity, making them a promising approach for colon cancer prevention.
Article
Engineering, Chemical
Adel Hidmi, Mahmoud Alzahayqa, Sharihan Erikat, Raghad Bahar, Lamia Hindi, Nawaf Al-Maharik, Zaidoun Salah
Summary: Cancer is a major cause of death worldwide, and current cancer drugs have limited potential. Curcumin, a natural product, and nitric oxide, a potential treatment for various diseases, have shown promise in cancer treatment. This study investigated the anti-cancer activities of an NO-Curcumin hybrid and found that it was more effective in reducing cell proliferation and increasing cell death compared to curcumin alone.
Review
Biochemistry & Molecular Biology
Ravneet Singh, Victoria L. Nasci, Ginger Guthrie, Lale A. Ertuglu, Maryam K. Butt, Annet Kirabo, Eman Y. Gohar
Summary: Cardiovascular and renal diseases are increasingly prevalent and age and sex differences play a role in their development and progression. GPER1 has been identified as an important regulator in cardio-renal health, particularly in aging individuals.
Review
Biochemistry & Molecular Biology
Silvia Guil-Luna, Maria Teresa Sanchez-Montero, Antonio Rodriguez-Ariza
Summary: This review provides an up-to-date overview of the role of S-nitrosylation at the intersection of metabolism and autophagy in cancer, including the involvement of S-nitrosylation in the metabolic adaptations in tumors, the multifaceted role of autophagy in cancer, and the impact of S-nitrosylation on autophagic dysregulation in cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Cell Biology
Fakiha Firdaus, Manish Kuchakulla, Rehana Qureshi, Raul Ariel Dulce, Yash Soni, Derek J. Van Booven, Khushi Shah, Thomas Masterson, Omar Joel Rosete, Sanoj Punnen, Joshua M. Hare, Ranjith Ramasamy, Himanshu Arora
Summary: In this study, sustained oxidative stress in castration-resistant prostate cancer cells was found to potentiate the tumor microenvironment. Targeting the tumor microenvironment using colony-stimulating factor 1 receptor inhibition is a promising therapy for castration-resistant prostate cancer. However, the efficacy of sustained colony-stimulating factor 1 receptor inhibition as a monotherapy is limited. The findings suggest that exogenous S-nitrosothiol administration induces S-nitrosylation of colony-stimulating factor 1 receptor and rescues the excess oxidation in tumor regions, thus suppressing tumor-promoting cytokines.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Physical
Peihua Li, Shiming Pu, Chao Lin, Liu He, Hongxia Zhao, Cheng Yang, Ziqi Guo, Shisan Xu, Zuping Zhou
Summary: Curcumin exhibits anti-colon cancer properties by inhibiting cell proliferation and inducing apoptosis through p53-mediated mechanisms.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Biochemistry & Molecular Biology
Christopher M. Massa, Ziping Liu, Sheryse Taylor, Ashley P. Pettit, Marena N. Stakheyeva, Elena Korotkova, Valentina Popova, Elena N. Atochina-Vasserman, Andrew J. Gow
Summary: The modification of protein cysteine residues by nitric oxide is important for various biological functions. The formation of stable nitrosothiols under biologically relevant conditions is discussed in this review, with a focus on the factors influencing the selective nature of this modification. The review also explores the reaction mechanisms and the impact of sources of NO and the chemical nature of potential reaction targets.
Article
Chemistry, Multidisciplinary
Zijie Luo, Gervase Ng, Yingzhu Zhou, Cyrille Boyer, Rona Chandrawati
Summary: Polymeric amines have been discovered to induce NO generation from RSNOs, and controlled NO release can be achieved by adjusting various factors. The NO-releasing feature can be integrated into different materials, and the potential of PVA/PEI hydrogels in Pseudomonas aeruginosa biofilm prevention has been demonstrated. The discovery in this study opens up new opportunities in NO-generating biomaterials for antibacterial, antiviral, anticancer, antithrombotic, and wound healing applications.