Journal
PROCESS BIOCHEMISTRY
Volume 45, Issue 12, Pages 1904-1911Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.procbio.2010.03.010
Keywords
Ganoderma lucidum; Integrated strategy; Multi-pulse feeding of carbon and nitrogen sources; Cu2+ multiple additions; Three-stage light irradiation
Categories
Funding
- National Natural Science Foundation of China (NSFC) [20706012, 20976038]
- National High Technology Research and Development Key Program of China (863 Key Program) [2007AA021506]
- National Basic Research Program of China ((973 Program) [2007CB714306]
- Key Project of Chinese Ministry of Education
- Hubei Provincial Natural Science Foundation for Innovative Research Team [2008CDA002]
- Discipline Leader Project of Wuhan Municipality [200951830553]
- Scientific Research Key Project of Hubei Provincial Department of Education
- Ministry of Education
- Hubei Provincial Department of Education, China
Ask authors/readers for more resources
To further enhance the accumulation of the bioactive metabolite ganoderic acid (GA) by fermentation of the medicinal mushroom Ganoderma lucidum, a novel integrated strategy was developed by simultaneously adopting a strategy of multiple Cu2+ additions, three-stage light irradiation and multi-pulse feeding of carbon and nitrogen sources. Maximal GA content (i.e., 4.1 mg/100 mg DW) and production (i.e., 720.8 mg/L) were obtained using the novel integrated strategy. Not only the biomass but also the total GA production obtained in this work is the highest reported for a shaker flask culture of G. lucidum. This work is useful for the large-scale production of GA by G. lucidum fermentation. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available