Journal
PROCESS BIOCHEMISTRY
Volume 44, Issue 8, Pages 928-933Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.procbio.2009.03.018
Keywords
Ganoderic acid; p53; Cell cycle; Ganoderic acid Me (GA-Me); Anti-tumor activity; Traditional Chinese medicine (TCM)
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Funding
- Shanghai Science & Technology Commission [054319933, 08DZ1971900]
- Shanghai Leading Academic Discipline Project [B203, B505]
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The mechanism of cell cycle arrest of tumor cells induced by ganoderic acid Me (GA-Me) is not understood. In this work, GA-Me was found to possess remarkable cytotoxicity on highly metastatic lung carcinoma 95-D cell line in both dose- and time-dependent manners. The effect of GA-Me on cell cycle arrest was found in 95-D, p53-null lung cancer cells H 1299, HCT-116 p53(+/+) and HCT-116 p53(-/-) human colon cancer cells. To obtain an insight into the role of p53 in cell cycle arrest by GA-Me, 95-D, H1299, HCT-116 p53(+/+) and HCT-116 p53(-/-) cells were used for further investigation. GA-Me arrested cell cycle at G, phase in 95-D and HCT-116 p53(+/+) cells while 5 phase or G(1)/S transition arrest in H1299 and HCT-116 p53(-/-) cells. The results suggested that p53 may be a target of CA-Me, and it may be looked at as a new promising candidate for the treatment of carcinoma cells. (C) 2009 Elsevier Ltd. All rights reserved.
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