Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma

CD201 and CD27 identify hematopoietic stem and progenitor cells across multiple murine strains independently of Kit and Sca-1

(2015) Sara E. Vazquez et al.   EXPERIMENTAL HEMATOLOGY

p53-Based Strategy for Protection of Bone Marrow From Y-90 Ibritumomab Tiuxetan

(2015) Hang Su et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Cell competition is a tumour suppressor mechanism in the thymus

(2014) Vera C. Martins et al.   NATURE

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

(2014) Terrence N. Wong et al.   NATURE

Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in Mice

(2014) Chang-Lung Lee et al.   RADIATION RESEARCH

NF1 Deletion Generates Multiple Subtypes of Soft-Tissue Sarcoma That Respond to MEK Inhibition

(2013) R. D. Dodd et al.   MOLECULAR CANCER THERAPEUTICS

Strategies for optimizing the response of cancer and normal tissues to radiation

(2013) Everett J. Moding et al.   NATURE REVIEWS DRUG DISCOVERY

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

(2012) V. Pant et al.   BLOOD

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Establishing a Murine Model of the Hematopoietic Syndrome of the Acute Radiation Syndrome

(2012) P. Artur Plett et al.   HEALTH PHYSICS

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Ionizing radiation and hematopoietic malignancies: Altering the adaptive landscape

(2010) Courtney J. Fleenor et al.   CELL CYCLE

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

(2010) Katerina I. Leonova et al.   CELL CYCLE

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

(2010) V. Labi et al.   GENES & DEVELOPMENT

Apoptosis-promoted tumorigenesis:  -irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

(2010) E. M. Michalak et al.   GENES & DEVELOPMENT

Pathologies Associated with the p53 Response

(2010) A. V. Gudkov et al.   Cold Spring Harbor Perspectives in Biology

Irradiation Selects for p53-Deficient Hematopoietic Progenitors

(2010) Andriy Marusyk et al.   PLOS BIOLOGY

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

(2009) D. G. Kent et al.   BLOOD

Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors

(2009) A. Marusyk et al.   CANCER RESEARCH

Late Mortality Among 5-Year Survivors of Childhood Cancer: A Summary From the Childhood Cancer Survivor Study

(2009) Gregory T. Armstrong et al.   JOURNAL OF CLINICAL ONCOLOGY

Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

(2009) George Hinkal et al.   PLoS One

Phenotypic and Functional Changes Induced in Hematopoietic Stem/Progenitor Cells After Gamma-Ray Radiation Exposure

(2009) Arthur J. Simonnet et al.   STEM CELLS

It's T-ALL about Notch

(2008) R M Demarest et al.   ONCOGENE