Article
Physics, Applied
Jie Huang, Qinxin Zhou, Xuemei Ren, Zheng Xu, Xiaojun Liu
Summary: Non-diffracting Bessel acoustic beams with self-healing, self-bending, and self-acceleration properties have potential applications for directional transportation of microbubbles. By adjusting the acoustic frequency, the maximum point of acoustic intensity on the beam mainlobe can be changed, and the curved trajectory and adjustable destination of microbubble transportation have been experimentally proven. The proposed method utilizes the conservative part of the radiation force to control the trajectory of microbubbles, making it suitable for in vivo applications.
APPLIED PHYSICS LETTERS
(2021)
Article
Multidisciplinary Sciences
Di Wu, Diego Baresch, Colin Cook, Zhichao Ma, Mengtong Duan, Dina Malounda, David Maresca, Maria P. Abundo, Justin Lee, Shirin Shivaei, David R. Mittelstein, Tian Qiu, Peer Fischer, Mikhail G. Shapiro
Summary: Ultrasound can manipulate cells with high precision through acoustic radiation force (ARF), but this ability is disconnected from cellular genetic programs due to the similar acoustic properties of most cells. Gas vesicles (GVs), a unique class of gas-filled protein nanostructures, can serve as genetically encodable actuators for selective acoustic manipulation. GVs experience strong ARF with opposite polarity to most other materials due to their lower density and higher compressibility relative to water. When expressed inside cells, GVs invert the cells' acoustic contrast and amplify their ARF, enabling selective manipulation of cells based on their genotype. GVs provide a direct link between gene expression and acoustomechanical actuation, opening up a paradigm for selective cellular control in a broad range of contexts.
Article
Physics, Multidisciplinary
Yan-Ping Wang, Fei-Yan Cai, Fei Li, Ru-Jun Zhang, Yong-Chuan Li, Jin-Ping Wang, Xin Zhang, Hai-Rong Zheng
Summary: Parallel manipulation and arrangement of particles and cells can be achieved using a two-dimensional phononic crystal plate, offering high-throughput, rapid, and flexible devices for manipulation.
ACTA PHYSICA SINICA
(2023)
Article
Acoustics
Jie Huang, Xuemei Ren, Qinxin Zhou, Junhe Zhou, Zheng Xu
Summary: This paper introduces a new method that combines surface acoustic waves (SAWs) with microfluidics technology to efficiently manipulate substances on the surface of a substrate. By designing appropriate acoustic lenses, nonplanar SAWs can be generated, and directional particle transport can be achieved. This method has the potential for flexible cell manipulation in microfluidics and biomedical applications.
Article
Physics, Multidisciplinary
Zhu Ji-Lin, Gao Dong-Bao, Zeng Xin-Wu
Summary: The acoustic radiation force enables acoustic tweezers to suspend and manipulate tiny particles. By deriving the direct relationship between the acoustic radiation force and sound pressure theoretically, a focused acoustic field model in acoustic tweezers is established, and methods for controlling and stabilizing the horizontal movement of particles are analyzed.
ACTA PHYSICA SINICA
(2021)
Article
Multidisciplinary Sciences
Ye Yang, Yaozhang Yang, Dingyuan Liu, Yuanyuan Wang, Minqiao Lu, Qi Zhang, Jiqing Huang, Yongchuan Li, Teng Ma, Fei Yan, Hairong Zheng
Summary: Acoustic tweezers are a technology that controls target movement through the interaction between acoustic waves and objects. This study demonstrates the use of genetically engineered bacteria that can produce sub-micron gas vesicles, enhancing their acoustic sensitivity and allowing manipulation by ultrasound. The bacteria can be trapped and manipulated using phased-array-based acoustic tweezers, enabling their flow in live mice.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Menyang Gong, Xin Xu, Yupei Qiao, Zhonghan Fei, Yuanyuan Li, Jiehui Liu, Aijun He, Xiaozhou Liu
Summary: This article presents a theoretical solution for the acoustic radiation force of an arbitrary beam on spherical particles in a spherical shell structure. Finite element simulation with specific parameters was conducted using bladder and urinary calculus as a background to verify the accuracy and feasibility of the theoretical solution. The study investigates the variation of the acoustic radiation force on the particles with particle radius, incident wave spectrum, viscosity coefficient of the medium inside the spherical shell structure, and distance from the center of the particle to the center of the spherical shell structure. This scheme provides a design idea and theoretical basis for the non-contact manipulation of particles inside the spherical shell structure, with a wide range of applications in industrial and life sciences.
RESULTS IN PHYSICS
(2023)
Article
Physics, Applied
Shifu Pu, Gepu Guo, Xiasheng Guo, Chenchen Zhou, Yuzhi Li, Qingyu Ma, Juan Tu, Dong Zhang
Summary: Auto-focusing acoustic-vortex (A-FAV) tweezers developed in this work use Half-Bessel beams to self-bend around obstacles, enabling stable object manipulation with improved resolution. The non-diffracting self-bending of HB beams allows for creation of obstacle-circumvention cavities, showing promise in various applications such as ultrasound imaging and object manipulation.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Engineering, Electrical & Electronic
Sonia Marrara, David Bronte Ciriza, Alessandro Magazzu, Roberto Caruso, Giuseppe Lupo, Rosalba Saija, Antonino Foti, Pietro Giuseppe Gucciardi, Andrea Mandanici, Onofrio Maria Marago, Maria Grazia Donato
Summary: Recently, acoustic tweezers inspired by holographic optical tweezers have been developed. The calibration of optical trap stiffnesses is essential in the latter technique, but seldom carried out in acoustic tweezers. In this work, the calibration protocols used in optical tweezers are adapted for acoustic tweezers based on ultrasonic transducer arrays. The measured trap stiffnesses are consistent with theoretical estimates, providing a common framework for optical and acoustic manipulation communities and enabling consistent calibration of hybrid acoustooptical setups.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Chemistry, Analytical
Rui You, Hang Wu, Wei Pang, Xuexin Duan
Summary: This paper presents a gigahertz bulk acoustic streaming tweezer (AST)-based micro-manipulation platform that can precisely and arbitrarily manipulate a single particle's movement. By controlling radio frequency signals, the intensity and direction of the acoustic streaming flow can be adjusted, allowing for versatile particle manipulation. The platform shows promising potential in various applications such as separation, assembly, sensing, and transportation.
ANALYTICAL CHEMISTRY
(2022)
Article
Acoustics
Everton B. Lima, Glauber T. Silva
Summary: The study introduces a semi-analytical approach for handling subwavelength axisymmetric particles immersed in an isotropic Newtonian fluid, with the obtained mean acoustic fields depending on scattering coefficients reflecting monopole and dipole modes. The method is validated by comparison with exact results and applied to a more realistic scenario involving red blood cells in blood plasma under ultrasonic waves.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Biochemical Research Methods
Hyeono Nam, Hyung Jin Sung, Jinsoo Park, Jessie S. Jeon
Summary: This study investigated the behaviors of microparticles and cancer cells inside a sessile droplet using surface acoustic waves. It explored the impact of droplet volume and contact angle on the behaviors of the particles, and demonstrated the non-contact manipulation property of acoustic waves, showing a biocompatible and structure-free platform configuration. The research also showed enhanced expression of E-cadherin in three-dimensional aggregated culture models of cancer cells and increased efficacy of the anticancer drug tirapazamine in aggregated cancer cells due to low oxygen levels.
Article
Physics, Applied
Ronghe Li, Yifei Li, Hande Sang, Yuanyuan Liu, Shuang Chen, Su Zhao
Summary: This study investigates the influence of ambient pressure on the load capacity of near-field acoustic levitation. Theoretical models based on acoustic radiation pressure and hydrodynamic lubrication theory are developed, considering the changes in ambient pressure. Both simulation and experimental results demonstrate that the levitation force is directly proportional to the ambient pressure. The levitation force increases by 4-5 times at an ambient pressure of 0.5 MPa, and a maximum load capacity of 0.309 MPa is achieved.
APPLIED PHYSICS LETTERS
(2022)
Review
Acoustics
Yu Liu, Qiu Yin, Ziyu Huang, Quansheng Cheng, Wenming Zhang, Bingpu Zhou, Yinning Zhou, Zhichao Ma
Summary: Manipulation of micro-objects, specifically in biochemical analysis or clinical diagnostics, is crucial. Acoustic methods, such as sub-MHz acoustic waves, offer various advantages including biocompatibility, tunability, and contactless control. These systems have been widely used in micro-analysis due to their low cost and accessibility from common acoustic devices. The applications of sub-MHz acoustic micromanipulation technologies, which are based on acoustic phenomena like cavitation and acoustic radiation force, hold great promise in biomedical fields for tasks like mixing, pumping, droplet generation, separation, patterning, rotation, propulsion, and actuation. The reviews of recent progresses in these systems highlight their potential for enhancing biomedicines and attracting further investigation.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Chemistry, Analytical
Shuai Wang, Xuewei Wang, Fucheng You, Han Xiao
Summary: Ultrasonic particle manipulation technique is a non-contact label-free method that utilizes ultrasound to manipulate micro- and nano-scale particles, gaining extensive attention in recent years. This paper introduces the principles, methods, and applicable scenarios of ultrasonic particle manipulation techniques, provides an overview of acoustic field generation methods, and analyzes and compares sound field reconstruction algorithms based on ultrasonic transducer arrays. It also explores the applications in engineering and biological fields, forecast the research progress, and provides superior guidance for micro and nano operations.
Article
Acoustics
Richard J. Pyle, Rhodri L. T. Bevan, Robert R. Hughes, Amine Ait Si Ali, Paul D. Wilcox
Summary: This study investigates the application of domain adaptation methods in ultrasonic crack characterization. By comparing three DA methods and two non-DA methods with varying sizes of experimental training data, it is found that the adversarial approach is the most effective way to utilize limited experimental training data.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Materials Science, Characterization & Testing
Sergio Cantero-Chinchilla, Paul D. Wilcox, Anthony J. Croxford
Summary: This paper presents a deep learning framework for artefact identification and suppression in nondestructive evaluation, which is based on the concept of autoencoders. Through experimental case study, it proves to be effective in accurately suppressing artefacts in complex scenarios and provides the physical parameters needed for imaging as well. Comparisons with state-of-the-art methodology based on image analysis are also made for artefact identification and suppression.
NDT & E INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Jie Zhang, Xudong Niu, Anthony J. Croxford, Bruce W. Drinkwater
Summary: This paper explores possible strategies for continuous non-destructive monitoring of large-scale structures using a collection of inspection robots. The robots use guided ultrasonic waves to detect and locate defects. Monte Carlo simulations reveal the compromise between the number of robots and defect location accuracy.
PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Article
Acoustics
Alexander R. K. Towlson, Anthony J. Croxford, Bruce W. Drinkwater
Summary: This article explores the use of a 40-kHz air-coupled ultrasonic array in detecting and imaging blockages and defects in buried pipes with 17-26 wavelengths in diameter at short ranges. The study finds that even low numbers of transducers (<25) are capable of producing accurate contours of blockages, but this restricts the resolving power. Arrays with more transducers ultimately image better by having greater density, resulting in improved contrast. Additionally, the interference between direct reflections and reflections via the pipe wall creates a low-amplitude band in all images of planar objects.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Multidisciplinary Sciences
Thomas R. Neil, Zhiyuan Shen, Daniel Robert, Bruce W. Drinkwater, Marc W. Holderied
Summary: Moth wings, acting as natural metamaterials, are found to be efficient sound absorbers through the action of resonant scales, making them potential candidates for sound-absorbing metasurface coatings.
PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Article
Engineering, Multidisciplinary
Xin L. Tu, Richard J. Pyle, Anthony J. Croxford, Paul D. Wilcox
Summary: The previous implementation of the nonlinear autoregressive network with exogenous input (NARX) showed excellent performance in defect detection in guided wave signals. However, it lacked robustness and its performance varied during training. By introducing a new NARX structure that enables multi-step prediction, the training process becomes more stable and the overall detection performance is improved.
STRUCTURAL HEALTH MONITORING-AN INTERNATIONAL JOURNAL
(2023)
Article
Clinical Neurology
Benjamin Clennell, Tom G. J. Steward, Kaliya Hanman, Tom Needham, Janette Benachour, Mark Jepson, Meg Elley, Nathan Halford, Kate Heesom, Eunju Shin, Elek Molnar, Bruce W. Drinkwater, Daniel J. Whitcomb
Summary: This study reveals the regulation of neuronal excitability and synaptic function by ultrasound stimulation. Ultrasound stimulation can increase whole-cell potassium currents and excitatory synaptic transmission. Activation of ionotropic glutamate receptors is required for ultrasound-induced modulation of neuronal potassium currents. These findings have important implications for the application of ultrasound stimulation in experimental and therapeutic settings, but further research is needed to understand the underlying molecular mechanisms.
Article
Materials Science, Characterization & Testing
Yuan Xue, Anthony J. Croxford, Paul D. Wilcox
Summary: This paper studies the impact of positioning inaccuracy, array element variability, and couplant wave velocity variability on inspection repeatability performance. It proposes a post-processing approach to compensate for the degradation in repeatability caused by changes in these parameters. The study finds that positioning inaccuracy and couplant wave velocity variability are the dominant factors affecting inspection repeatability, and the effect of element variability is negligible. The proposed compensation approach offers significant performance advantages for baseline subtraction and early-stage crack detection.
NDT & E INTERNATIONAL
(2023)
Article
Materials Science, Characterization & Testing
Xudong Niu, Jie Zhang, Anthony Croxford, Bruce Drinkwater
Summary: This study explores how to accurately simulate the elastodynamic scattering behavior of an arbitrary defect using finite element analysis. The method involves measuring the scattered wave field and decomposing it into multi-modal far-field scattering amplitudes to determine the angular order of scattering. The results show that this approach allows for more efficient modeling of guided wave scattering and contributes to a better understanding of experimental defect characterization.
NONDESTRUCTIVE TESTING AND EVALUATION
(2023)
Article
Acoustics
Richard J. Pyle, Robert R. Hughes, Paul D. Wilcox
Summary: This article proposes a novel dimensionality reduction method called Gaussian feature approximation (GFA) to improve the interpretability and explainability of machine learning for ultrasonic nondestructive evaluation (NDE). GFA is applied to ultrasonic defect sizing and compared with other dimensionality reduction methods and a convolutional neural network. The results show that GFA features achieve similar sizing accuracy to raw images with a significant reduction in input data dimensionality. The GFA-based neural network also exhibits similar relationships between defect indications and predicted size as traditional NDE sizing methods.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Review
Chemistry, Multidisciplinary
Chengying Yin, Xingyu Jiang, Stephen Mann, Liangfei Tian, Bruce W. Drinkwater
Summary: The high throughput deposition of microscale objects with precise spatial arrangement is crucial in microfabrication technology. The utilization of dynamic acoustic fields offers a contactless approach to real-time reconfigurable miniaturized systems, with potential applications in various fields. This article discusses the physical interactions of microscale objects in an acoustic pressure field, the fabrication of acoustic trapping devices, methods to tune the spatial arrangement, and potential applications in different disciplines.
Article
Materials Science, Characterization & Testing
Sergio Cantero-Chinchilla, Anthony J. Croxford, Paul D. Wilcox
Summary: This paper proposes a data-driven framework for artefact suppression in non-destructive testing data. The framework involves two stages of dimensionality reduction using principal component analysis and an autoencoder. The proposed method effectively suppresses artefacts leading to good defect detection and characterisation performance in an ultrasonic phased-array imaging application.
NDT & E INTERNATIONAL
(2023)
Article
Acoustics
Zubeir M. Ebrahim Saib, Anthony J. Croxford, Bruce W. Drinkwater
Summary: This paper proposes a numerical model using FDTD scheme to solve the nonlinear elastic bulk wave equations, aiming to better understand nonlinear ultrasonic techniques. The model considers material and geometrical nonlinearities and uses a stress-type boundary condition for excitation. Simulation and experimental results validate the effectiveness of the model.
Article
Engineering, Multidisciplinary
Meirbek Mussatayev, Qiuji Yi, Mark Fitzgerald, Vincent K. Maes, Paul Wilcox, Robert Hughes
Summary: Real-time monitoring of carbon fibre composites during Automated Fibre Placement (AFP) manufacturing remains a challenge for non-destructive evaluation (NDE) techniques. This study designed a directional eddy-current (EC) probe to evaluate the detectability of out-of-plane wrinkles. Experimental evaluations and finite element modeling were conducted to better understand the relationship between eddy-current density and defect detection. The findings suggest that the probe configuration with an asymmetric driver coil and differential pickup coils shows the best capability for wrinkle detection.
COMPOSITES PART B-ENGINEERING
(2024)
Article
Acoustics
Zubeir M. Ebrahim Saib, Anthony J. Croxford, Bruce W. Drinkwater
Summary: This paper investigates the effect of the excitation envelope on the generated nonlinear resonant signal for shear and longitudinal wave collinear wave mixing. It explores how to accurately extract the absolute material nonlinearity from any enveloped sinusoidal excitation signal. Experimental results show that Hanning windowed tone burst inputs have lower variance and are suitable for measuring the absolute nonlinearity parameter.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
