Article
Multidisciplinary Sciences
Jiujun Zhu, Dechuang Jiao, Yajie Zhao, Xuhui Guo, Yue Yang, Hui Xiao, Zhenzhen Liu
Summary: Neutrophils and lymphocytes play crucial roles in breast cancer development and progression. The Neutrophil to lymphocyte ratio (NLR) has been shown to be a valuable prognostic marker for evaluating BC patients. Lower baseline NLR values are associated with a higher likelihood of achieving pathological complete response (pCR) following neoadjuvant chemotherapy (NCT) treatment.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Jeong Won Lee, Ki Ho Seol
Summary: The study found that high NLR-PLR is associated with poor clinical outcomes, while increases in both NLR and PLR are correlated with lower survival rates for patients. Elevation in both NLR and PLR before initiation of CCRT may be a useful biomarker for predicting clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Agnieszka Pikula, Magdalena Skorzewska, Zuzanna Pelc, Radoslaw Mlak, Katarzyna Geca, Katarzyna Sedlak, Bogumila Cisel, Magdalena Kwietniewska, Karol Rawicz-Pruszynski, Wojciech P. Polkowski
Summary: The study confirmed the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in advanced gastric cancer patients, serving as significant prognostic factors.
Review
Oncology
Aurelien Lambert, Lilian Schwarz, Michel Ducreux, Thierry Conroy
Summary: Only 10-20% of patients with resectable pancreatic adenocarcinoma have potentially resectable disease. After surgical extirpation of tumors, up to 80% of patients will develop cancer recurrence, and adjuvant chemotherapy is the best strategy to improve overall survival. Neoadjuvant treatment shows some promising results but still requires further investigation to be validated.
Article
Gastroenterology & Hepatology
Christina Fleming
Summary: Combining post-NACRT inflammatory markers with restaging MRI and endoscopy findings adds another avenue to aid distinguishing residual disease (RD) from complete clinical response (cCR) in rectal cancer.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Cell Biology
Antonino Grassadonia, Vincenzo Graziano, Laura Iezzi, Patrizia Vici, Maddalena Barba, Laura Pizzuti, Giuseppe Cicero, Eriseld Krasniqi, Marco Mazzotta, Daniele Marinelli, Antonella Amodio, Clara Natoli, Nicola Tinari
Summary: The study found that in patients with luminal breast cancer receiving neoadjuvant chemotherapy, pre-treatment NLRlow was significantly associated with shorter DFS and OS. Additionally, non-ductal histology, luminal B subtype, and post-treatment Ki67 >= 14% were also associated with worse DFS.
Article
Oncology
Youzhao Ma, Jingyang Zhang, Xiuchun Chen
Summary: This study demonstrated that LMR can serve as a potential marker for predicting the efficacy and prognosis of patients with breast cancer. Patients with low LMR, HER-2 positive, and lymph node status (N2-3) showed poor disease-free survival outcomes.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Chun-Ming Huang, Ming-Yii Huang, Hsiang-Lin Tsai, Ching-Wen Huang, Wei-Chih Su, Tsung-Kun Chang, Yen-Cheng Chen, Ching-Chun Li, Jaw-Yuan Wang
Summary: The study found that a high neutrophil-to-lymphocyte ratio (NLR) before treatment (>= 3.2) was an independent predictor of reduced overall survival and disease-free survival in locally advanced rectal cancer patients who achieved a pathological complete response to neoadjuvant chemoradiotherapy. High NLR was significantly associated with tumor recurrence and could serve as a promising predictor for poor outcomes in this patient population.
Article
Oncology
Yuma Wada, Masaaki Nishi, Kozo Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto, Mitsuo Shimada
Summary: This study reveals the clinical importance of evaluating the lymph node response to neoadjuvant chemotherapy in predicting survival outcomes for patients with gastric cancer.
Article
Oncology
Ozgur Acikgoz, Anil Yildiz, Ahmet Bilici, Omer Fatih Olmez, Pelin Basim, Asli Cakir
Summary: This study investigated the predictive value of PLR and NLR as indicators of pCR in breast cancer patients after NACT. The results showed that PLR and NLR are independent factors for predicting pCR to NACT, and they have a good correlation.
Article
Surgery
Gaohua Yang, Pengju Liu, Longtian Zheng, Jianfeng Zeng
Summary: The NLR, PLR, and SII before neoadjuvant chemotherapy can be used as predictors of pathological complete response in breast cancer patients, with SII having a higher predictive value and low SII associated with a higher likelihood of achieving pCR.
FRONTIERS IN SURGERY
(2022)
Article
Obstetrics & Gynecology
Alexandra von Au, Samra Shencoru, Lorenz Uhlmann, Luisa Mayer, Laura Michel, Markus Wallwiener, Andre Hennigs, Thomas Deutsch, Fabian Riedel, Joerg Heil, Michael Golatta, Andreas Schneeweiss, Florian Schuetz, Christoph Domschke
Summary: This study investigated the value of neutrophil-to-lymphocyte ratio (NLR) in peripheral blood as a predictor of treatment response in breast cancer patients receiving neoadjuvant chemotherapy. The results showed that NLR was significantly higher in patients achieving pathologic complete response (pCR) in the Luminal B/Her2-negative and postmenopausal subgroups.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Oncology
Siming Gao, Wenjie Tang, Bingli Zuo, Lianne Mulvihill, Jinming Yu, Yishan Yu
Summary: This study investigates the predictive role of neutrophil-to-lymphocyte ratio (NLR) in overall survival (OS) and pathologic complete response (pCR) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). A total of 501 patients were included in the retrospective analysis, and it was found that NLR was correlated with OS and pCR. A novel model for predicting OS was established, and it was also observed that non-pCR patients experienced an increase in NLR during NAC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Haijun Tang, Dehuai Liu, Jili Lu, Juliang He, Shuyu Ji, Shijie Liao, Qingjun Wei, Shenglin Lu, Yun Liu
Summary: This study found that the neutrophil-to-lymphocyte ratio (NLR) can serve as a predictive factor for the efficacy of neoadjuvant chemotherapy (NACT) in extremity osteosarcoma. Patients with a lower NLR are more likely to achieve pathological complete response (pCR). This finding can guide treatment strategies for osteosarcoma patients.
Article
Oncology
Zhong-Guo Liang, Fan Zhang, Ye Li, Ling Li, Song Qu, Fang Su, Bin-Bin Yu, Ying Guan, Lu Han, Kai-Guo Li, Xiao-Dong Zhu
Summary: Integrating NLR into the 8th edition of the AJCC staging system could improve the separation and discriminatory abilities for N classifications, but not for T categories. Patients in the RPA 4 group could benefit significantly from the addition of adjuvant chemotherapy to concurrent chemoradiotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Oncology
Goro Ueno, Yoshifumi Iwagami, Shogo Kobayashi, Suguru Mitsufuji, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Goro Ueno, Yoshifumi Iwagami, Shogo Kobayashi, Suguru Mitsufuji, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yoshihiro Sakano, Takehiro Noda, Shogo Kobayashi, Akihiro Kitagawa, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Kunihito Gotoh, Tadafumi Asaoka, Masahiro Tanemura, Koji Umeshita, Koshi Mimori, Yuichiro Doki, Hidetoshi Eguchi
Summary: High ACYP1 expression could affect the prognosis of cHCC-iCCA, HCC, and iCCA patients. In vitro, ACYP1 expression influences tumor growth and cell viability in both HCC and iCCA by regulating anti-apoptosis proteins.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Keisuke Toya, Yoshito Tomimaru, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the healing time and potential factors associated with the healing time of postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). The study found that the neutrophil-to-lymphocyte ratio was the only factor independently associated with the healing time of POPF. Patients with a lower neutrophil-to-lymphocyte ratio had significantly shorter healing times for POPF after DP.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2022)
Article
Oncology
Suguru Mitsufuji, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study found that CLU inhibition leads to cellular senescence in PDAC. Our findings suggest that CLU is a novel therapeutic target that contributes to the prognosis of PDAC by inducing cellular senescence.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Kazuya Kato, Yoshifumi Iwagami, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Tadafumi Asaoka, Takehiro Noda, Hidenori Takahashi, Masahiro Tanemura, Hiroki Kiyokawa, Shinichiro Tahara, Eiichi Morii, Yuichiro Doki, Hidetoshi Eguchi
Summary: Colorectal liver metastasis (CRLM) with bile duct tumor thrombus (BDTT) is a rare condition often diagnosed after surgical resection. We report a case of a 79 year-old woman with CRLM associated with BDTT. This case highlights the importance of considering CRLM with BDTT and surgical treatment in patients with a history of colorectal cancer presenting with BDTT.
INTERNATIONAL CANCER CONFERENCE JOURNAL
(2023)
Editorial Material
Oncology
Takeshi Kado, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Takeshi Kado, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study demonstrates that GDA involvement is an independent factor significantly associated with postoperative survival in PDAC. Patients with GDA contact > 180 degrees have a poorer prognosis, which may be linked to the development of postoperative distant metastasis.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the impact of changes in body composition on postoperative outcomes in patients with PDAC undergoing neoadjuvant chemoradiotherapy. The results showed that loss of skeletal muscle mass during NACRT was an independent risk factor for survival in PDAC patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Takeshi Kado, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yoshito Tomimaru, Hidetoshi Eguchi, Yosuke Inoue, Yuichi Nagakawa, Akihiro Ohba, Hideki Takami, Michiaki Unno, Tomohisa Yamamoto, Shoji Kawakatsu, Tsuyoshi Hayashi, Ryota Higuchi, Hirohisa Kitagawa, Satoshi Hattori, Tsutomu Fujii, Yoshiki Hirooka, Hisato Igarashi, Masayuki Kitano, Tamotsu Kuroki, Atsushi Masamune, Yasuhiro Shimizu, Masaji Tani, Satoshi Tanno, Yoshihisa Tsuji, Hiroki Yamaue, Sohei Satoi, Yoshifumi Takeyama
Summary: Based on a study by the Japan Adjuvant Study Group, the standard adjuvant chemotherapy duration for pancreatic ductal adenocarcinoma (PDAC) is 6 months. This study aimed to investigate the impact of extending the duration of S-1 chemotherapy on postoperative survival in PDAC patients using real-world data.
Article
Oncology
Daiki Marukawa, Kunihito Gotoh, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study found that high expression of Rubicon is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy. In addition, downregulation of Rubicon can improve invasion ability and cell viability in gemcitabine-resistant pancreatic ductal adenocarcinoma.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hiroki Imamura, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
Summary: After pancreatojejunostomy for pancreatic head resection, contrast-enhanced computed tomography may reveal a hypoattenuated area at the pancreatojejunostomy site. The clinical significance of this hypoattenuated area in terms of postoperative pancreatic fistula is still unknown.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)