Article
Oncology
Xin-ping Yu, Lei Wang, Hai-yang Yu, Yu-wei Zou, Chang Wang, Jin-wen Jiao, Hao Hong, Shuai Zhang
Summary: MDCT-based radiomics features can be used as biomarkers for the differentiation of SBOTs and SMOTs, with no significant differences found among the three models incorporating radiomics parameters generated by SVM classifiers in each phase.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Optics
Yulu Huang, Anli Hou, Jing Wang, Yue Yao, Wenbin Miao, Xuewu Tian, Jiawen Yu, Cheng Li, Hui Ma, Yujuan Fan
Summary: Ovarian cancer is a highly aggressive and heterogeneous tumor. This study investigated the use of Mueller matrix microscopy and machine learning models to distinguish different types of serous ovarian tumors. The extracted polarimetry feature parameters were found to be useful for quantitatively differentiating tumor types and correlated with clinicopathological features.
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
(2022)
Review
Reproductive Biology
Romana Idrees, Nasir Ud Din, Sabeehudin Siddique, Saira Fatima, Jamshid Abdul-Ghafar, Zubair Ahmad
Summary: In our series, 4 cases originally diagnosed as seromucinous carcinomas were reclassified as endometrioid carcinomas with mucinous differentiation according to the 2020 WHO Classification of Female Genital Tumours. Six cases were diagnosed as seromucinous borderline tumors, in agreement with published literature.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biology
Emilee N. Kotnik, Mary M. Mullen, Nicholas C. Spies, Tiandao Li, Matthew Inkman, Jin Zhang, Fernanda Martins-Rodrigues, Ian S. Hagemann, Carolyn K. McCourt, Premal H. Thaker, Andrea R. Hagemann, Matthew A. Powell, David G. Mutch, Dineo Khabele, Gregory D. Longmore, Elaine R. Mardis, Christopher A. Maher, Christopher A. Miller, Katherine C. Fuh
Summary: Analysis of genomic and transcriptomic alterations in primary and metastatic tumors of high-grade serous ovarian cancer patients reveals differences associated with survival outcomes, providing insights for personalized treatment options and drug development.
COMMUNICATIONS BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kui Li, Feifei Song, Linling Yu, Haiyan Shi, Jida Wang, Xiaodong Cheng
Summary: This study investigated the diagnostic value of MRI in SBOT and found an accuracy of 87.6% in diagnosing SBOT, with MRI features consistent with clinicopathological characteristics. Three MRI morphological patterns of SBOT were identified, with PA&IB structure as a characteristic finding. While SBOT-MP tended to display more aggressive clinical behavior, their MRI features were similar to SBOT-C.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Medicine, General & Internal
Dan Wu, Yuzhou Lei, Qin Liu, Hua Hu, Huanhuan Li, Lin Xie, Jianbin Zhou
Summary: The study revealed that the expression profile of the CADM1/HER2/STAT3 axis was closely associated with histologic type, stage, and lymph node metastasis in patients with SOT. These molecular data may provide new insights into SOT carcinogenesis and aid in the diagnosis and treatment of patients with SOT.
Article
Oncology
Sebastien Gouy, Sophie Maria, Matthieu Faron, Amandine Maulard, Patricia Pautier, Alexandra Leary, Cyrus Chargari, Catherine Genestie, Philippe Morice
Summary: This study aimed to assess the outcomes of conservatively treated stage II/III serous borderline tumors of the ovary (SBOTs) with long-term follow-up. Among 212 patients reviewed, 65 underwent conservative treatment, with 38 experiencing recurrences. Conservative treatment was found to be a prognostic factor for disease-free survival but did not impact overall survival, although three deaths occurred.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biochemical Research Methods
Kristina A. Thomsson, Varvara Vitiazeva, Constantina Mateoiu, Chunsheng Jin, Jining Liu, Jan Holgersson, Birgitta Weijdegard, Karin Sundfeldt, Niclas G. Karlsson
Summary: This study identifies a complex sulfation pattern of O-glycans on OC glycoproteins, and shows that the aggressiveness of the cancer is associated with decreased expression of the Gal3ST2 transferase.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Editorial Material
Oncology
Paola Romeo, Damiano Arciuolo, Maria Cristina Moruzzi, Francesca Moro
Summary: The videos present two cases of serous epithelial ovarian carcinomas, showcasing the clinical, ultrasound, macroscopic, and histological features of a high grade serous ovarian carcinoma patient in the first video and a low grade serous ovarian carcinoma patient in the second video.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Medicine, General & Internal
Daniela Travaglio Morales, Carlos Huerga Cabrerizo, Itsaso Losantos Garcia, Monica Coronado Poggio, Jose Manuel Cordero Garcia, Elena Lopez Llobet, Domenico Monachello Araujo, Sebastian Rizkallal Monzon, Luis Dominguez Gadea
Summary: This study evaluated the prognostic value of pretreatment 18F-FDG PET radiomic features in patients with HGSOC. The results indicated that TLG, GLSZM_ZSNU, and GLRLM_RLNU were significantly associated with DFS. Survival curve analysis showed a significant difference in DFS between patients with GLRLM_RLNU > 7388.3 and those with lower values, indicating that these features may be used for predicting the prognosis of HGSOC patients.
Article
Oncology
Maritza S. Mosella, Thais S. Sabedot, Tiago C. Silva, Tathiane M. Malta, Felipe Segato Dezem, Karam P. Asmaro, Michael Wells, Abir Mukherjee, Laila M. Poisson, James Snyder, Ana C. deCarvalho, Tobias Walbert, Todd Aho, Steven Kalkanis, Paula C. Elias, Sonir R. Antonini, Jack Rock, Houtan Noushmehr, Margaret Castro, Ana Valeria Castrot
Summary: This study identified and validated methylation signatures that classify pituitary neuroendocrine tumors (PitNETs) based on distinct adenohypophyseal cell lineages and functional status. The differentially methylated probes (DMP) accurately assigned samples to their lineage and functional subtype memberships in a validation cohort. The DMPs were annotated in regulatory regions enriched with enhancer elements, associated with pathways and genes involved in pituitary cell biology and tumorigenesis.
Article
Public, Environmental & Occupational Health
Lina Niu, Huihui Tian, Yongjun Xu, Jieqiong Cao, Xu Zhang, Junli Zhang, Jiajia Hou, Weiqin Lv, Junxia Wang, Li Xin, XuFeng Dong, Tao Xu, Yuan Nan, Hua Wei, Xinting Chai, Na Li, Yan Ni, Yun Shang, Lizhen Zhang, Ye Zhao
Summary: Borderline ovarian tumors (BOTs) typically occur in women under the age of 40, with an occult onset and half of patients having no obvious clinical manifestations. The serum CA125 level can serve as a tumor marker to detect BOTs and assess the risk of recurrence. The mode of operation and FIGO stage are important independent factors for the recurrence of BOTs.
Article
Reproductive Biology
Shuang Ye, Wei Chen, Yuwei Zheng, Yutuan Wu, Libing Xiang, Teng Li, Bo Ping, Xiaoming Zhang, Huijuan Yang
Summary: Peripheral lymphocyte subsets undergo significant changes in ovarian cancer patients, with elevated levels of regulatory T cells and decreased levels of CD3(+)CD8(+) T and CD8(+)CD28(+) T cells. The decrease in B cell levels may be related to disease aggressiveness.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Oncology
Puja Dey, Kentaro Nakayama, Sultana Razia, Masako Ishikawa, Tomoka Ishibashi, Hitomi Yamashita, Kosuke Kanno, Seiya Sato, Tohru Kiyono, Satoru Kyo
Summary: This study successfully developed an in vitro carcinogenic model of LGSOCs and found that the mutations of KRAS and PIK3CA play a causative role in LGSOC tumorigenesis. Simultaneous activation of the KRAS/ERK and PIK3CA/AKT signaling pathways is essential for LGSOC development.
Article
Medicine, General & Internal
Ziyang Lu, Fanghe Lin, Tao Li, Jinhui Wang, Cenxi Liu, Guangxing Lu, Bin Li, MingPei Pan, Shaohua Fan, Junqiu Yue, He Huang, Jia Song, Chao Gu, Jin Li
Summary: Through analysis and research, we have identified several important clinical and molecular features related to the recurrence of SBOT. We have also developed a prediction tool that can help physicians assess the prognosis of patients with SBOT. These findings are significant for the development of personalized and targeted therapies to improve prognosis.
