Article
Oncology
Jianyuan Feng, Jiarui Zhang, Yanling Li, Weilun Cheng, Yansong Liu, Ziang Chen, Yunqiang Duan, Tianshui Yu, Anbang Hu, Ting Wang, Hanyu Zhang, Mingcui Li, Zhiyuan Rong, Fei Ma, Baoliang Guo
Summary: This study found that lncRNA PCAT19 regulates the development of breast cancer and may serve as a prognostic biomarker for breast cancer patients.
Article
Multidisciplinary Sciences
Christina Westhoff, Sabrina Mueller, Paul Jank, Matthias Kalder, Roland Moll
Summary: Several studies have shown the presence of lymphangiogenesis in metastases of breast cancer, and the number of lymph vessels in metastases is significantly correlated with metastasis size. However, no lymphangiogenesis was detected in tumor-free lymph nodes. D2-40 staining was frequently detected in the sinus endothelium of lymph nodes, and a higher proportion of stained sinus in sentinel lymph nodes was associated with worse overall survival and served as an independent prognostic factor. Further studies are needed to understand the biological and clinical significance of the observed immunophenotypic variations of nodal sinus endothelium.
Article
Biochemistry & Molecular Biology
Gabriela Regina Rosa Souza, Milene Dalmina, Jelver Alexander Sierra Restrepo, Leonidas Joao de Mello Junior, Adny Henrique Silva, Ana Gualberto, Jacy Gameiro, Dalton Dittz, Andre Avelino Pasa, Frederico Pittella, Tania Beatriz Creczynski-Pasa
Summary: A hybrid nanocarrier composed of calcium phosphate and a block copolymer was successfully developed to deliver VEGF siRNA into metastatic breast cancer in mice, resulting in a significant decrease in tumor size. The study demonstrates the potential of this nanocarrier in achieving RNAi effect and tumor therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Pharmacology & Pharmacy
Kiruthiga Chandramohan, Devasahayam Jaya Balan, Kasi Pandima Devi, Seyed Fazel Nabavi, Sara Reshadat, Maryam Khayatkashani, Sepideh Mahmoodifar, Rosanna Filosa, Niloufar Amirkhalili, Soroush Pishvaei, Omolbanin Sargazi-Aval, Seyed Mohammad Nabavi
Summary: Colorectal cancer is a common and deadly disease, especially among older individuals. Chemotherapy has negative effects on both normal and malignant cells. Various signaling pathways, such as Hh, JAK/STAT, Wnt/beta-catenin, TNF-beta, EGFR/MAPK, PI3K, NF-kappa B, and Notch, are involved in the development of colorectal cancer. This study focuses on innovative siRNA therapies and delivery methods for the safe and effective treatment of colorectal cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Huimin Xu, Jianqiao Chang, Hao Wu, Haoyu Wang, Wenjing Xie, Yunchao Li, Xiaohong Li, Yang Zhang, Louzhen Fan
Summary: siRNA-based gene therapy is a promising strategy for tumor treatment. Novel gene vectors, such as LAAM GUA-CDs, which can target tumor cells and deliver siRNA without causing side effects, have been designed and synthesized. LAAM GUA-CDs loaded with siBcl-2 exhibit a high tumor inhibition rate, twice as effective as commercial Lipofectamine 2000. LAAM GUA-CDs provide a versatile approach for tumor-targeted siRNA delivery and cancer therapy.
Article
Plant Sciences
Jinqiu Fu, Shijing Xu, Huan Lu, Fanchi Li, Shengchun Li, Ling Chang, David G. Heckel, Ralph Bock, Jiang Zhang
Summary: Plant-mediated RNA interference (RNAi) using dsRNA or siRNA has shown promise in pest control, but little is known about the molecular mechanisms. This study found that siRNAs derived from transgenic plants may be more effective triggers of RNAi in Lepidoptera than dsRNAs.
PLANT CELL AND ENVIRONMENT
(2022)
Review
Pharmacology & Pharmacy
Junyu Wu, Yang Long, Man Li, Qin He
Summary: Despite advances in cancer treatment, tumor metastasis remains a challenging problem that hinders therapeutic outcomes. The application of nanotechnology has provided new possibilities for anti-metastasis treatment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Multidisciplinary
Aristides D. Tagalakis, Vignesh Jayarajan, Ruhina Maeshima, Kin H. Ho, Farhatullah Syed, Lin-Ping Wu, Ahmad M. Aldossary, Mustafa M. Munye, Talisa Mistry, Olumide Kayode Ogunbiyi, Arturo Sala, Joseph F. Standing, Seyed M. Moghimi, Andrew W. Stoker, Stephen L. Hart
Summary: This study introduces a novel formulation of siRNA nanoparticles, termed RTNs, which can target tumors effectively while minimizing clearance by the liver, resulting in predominant accumulation in tumors rather than other organs in the body. The experiment demonstrates that these siRNA nanoparticles significantly retard the growth of xenograft tumors and improve survival rates, showing promise for delivering targeted siRNA therapeutics for cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Immunology
Fumi Seto -Tetsuo, Masaki Arioka, Koichi Miura, Takeru Inoue, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri
Summary: The tumor microenvironment (TME) composed of tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) plays a key role in cancer progression. This study investigated the effect of a small molecule, differentiation-inducing factor-1 (DIF-1), on the TME. It was found that DIF-1 inhibited the polarization of macrophages into TAMs induced by 4T1 cell-conditioned medium and suppressed the differentiation of fibroblasts into CAF-like cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Virology
Amrita Haikerwal, Michael D. Barrera, Nishank Bhalla, Weidong Zhou, Niloufar Boghdeh, Carol Anderson, Farhang Alem, Aarthi Narayanan
Summary: vsiRNAs show antiviral activity against VEEV infection, but the inhibition is overcome at later time points. The RNAi pathway plays an important role in the inhibition of viral infection.
Article
Multidisciplinary Sciences
Masa Aleckovic, Simona Cristea, Carlos R. Gil Del Alcazar, Pengze Yan, Lina Ding, Ethan D. Krop, Nicholas W. Harper, Ernesto Rojas Jimenez, Donghao Lu, Anushree C. Gulvady, Pierre Foidart, Marco Seehawer, Benedetto Diciaccio, Katherine C. Murphy, Jason Pyrdol, Jayati Anand, Kodie Garza, Kai W. Wucherpfennig, Rulla M. Tamimi, Franziska Michor, Kornelia Polyak
Summary: TGF beta signaling plays a critical role in breast cancer risk. Short-term treatment with TGFBR inhibitors prevents mammary tumors in rats and is associated with a unique epithelial subpopulation called secretory basal cells (SBCs), which are also found in human breast tissues and associated with breast cancer risk. Furthermore, SBCs are identified as the most interactive cell population and the main source of insulin-IGF signaling, and the inhibition of TGFBR and IGF1R decreases proliferation. These findings provide a proof-of-principle cancer prevention strategy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Sen Liu, Xu Chen, Tianxin Lin
Summary: The article summarizes the molecular mechanisms of lymphatic metastasis in bladder cancer, including lymphangiogenesis, noncoding RNAs, and microenvironment-associated molecules. Newly discovered radiomics and genomics approaches have improved the preoperative diagnostic accuracy of lymph node metastasis, potentially leading to promising therapeutic strategies.
Review
Medicine, General & Internal
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko
Summary: Breast cancer is the most common and lethal malignancy in women. Its development is influenced by factors such as age, genetic mutations, and body weight. Currently, there is a lack of sensitive and specific screening tests, but researchers are exploring new diagnostic biomarkers. The VEGF family of proteins and their receptors play a significant role in the pathogenesis of breast cancer and could potentially be used as diagnostic biomarkers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Anastasia Chilla, Cecilia Anceschi, Elena Frediani, Francesca Scavone, Tommaso Del Rosso, Giuseppe Pelagio, Antonio Tufaro, Giuseppe De Palma, Mario Del Rosso, Gabriella Fibbi, Paola Chiarugi, Anna Laurenzana, Francesca Margheri
Summary: Studies have found that inhibitors of matrix metalloproteinase (MMPs) as anti-tumoral drugs have been disappointing. Recent research shows that endothelial cells and endothelial colony forming cells (ECFCs) can switch invasion modes and perform amoeboid angiogenesis in the absence of protease activity. TIMP1, TIMP2, and TIMP3 have been identified as high-powered protease inhibitors that can induce amoeboid invasion of ECFCs, while Marimastat promotes ECFC invasion and tubular formation. It is important to consider the amoeboid mechanism of invasion in developing new cancer drugs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Miguel Hernandez-Quiles, Rosalie Baak, Alba Orea-Soufi, Anouska Borgman, Suzanne den Haan, Paula Sobrevals Alcaraz, Aldo Jongejan, Robert van Es, Guillermo Velasco, Harmjan Vos, Eric Kalkhoven
Summary: This study reveals the regulatory role of TRIB3 in the expression of PPAR gamma, suggesting its involvement in breast cancer initiation and metastasis. The researchers found that TRIB3 interferes with the MLL complex, leading to reduced H3K4 trimethylation of the PPARG locus and decreased PPAR gamma mRNA expression. These findings provide insights into potential therapeutic targets for breast cancer treatment using PPAR gamma ligands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)