Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

Why do malaria parasites increase host erythrocyte permeability?

(2014) Sanjay A. Desai   TRENDS IN PARASITOLOGY

Borrelidin analogues with antimalarial activity: Design, synthesis and biological evaluation against Plasmodium falciparum parasites

(2013) Akihiro Sugawara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin

(2013) IG Azcárate et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective Inhibition of an Apicoplastic Aminoacyl-tRNA Synthetase fromPlasmodium falciparum

(2013) Rob Hoen et al.   CHEMBIOCHEM

Malaria

(2013) Nicholas J White et al.   LANCET

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

(2013) Tamara F. Williams et al.   Scientific Reports

Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

(2012) Daniel E. Goldberg et al.   CELL

An All-Purpose Antimalarial Drug Target

(2012) W. Armand Guiguemde et al.   Cell Host & Microbe

Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

(2012) Dominic Hoepfner et al.   Cell Host & Microbe

Ion and nutrient uptake by malaria parasite-infected erythrocytes

(2012) Sanjay A. Desai   CELLULAR MICROBIOLOGY

Antimalarial Drug Resistance and Early Drug Discovery

(2012) Jose F. Garcia-Bustos et al.   CURRENT PHARMACEUTICAL DESIGN

Boron-based drugs as antiprotozoals

(2011) Robert T. Jacobs et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum

(2011) Katherine E. Jackson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum

(2011) Aki Ishiyama et al.   JOURNAL OF ANTIBIOTICS

A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro

(2011) Patricia Urbán et al.   JOURNAL OF CONTROLLED RELEASE

Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages

(2011) Carlos Moneriz et al.   MALARIA JOURNAL

Validation of isoleucine utilization targets in Plasmodium falciparum

(2011) E. S. Istvan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms

(2010) J. Woolard et al.   Chemical Science

Plasmodium falciparum Drug Resistance in Madagascar: Facing the Spread of Unusual pfdhfr and pfmdr-1 Haplotypes and the Decrease of Dihydroartemisinin Susceptibility

(2009) V. Andriantsoanirina et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies

(2009) Maryline Bonnet et al.   MALARIA JOURNAL

Changes in the Treatment Responses to Artesunate-Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment

(2009) Verena Ilona Carrara et al.   PLoS One

Antimalarial Drugs – What is in Use and What is in the Pipeline

(2008) Martin Schlitzer   ARCHIV DER PHARMAZIE

Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases

(2008) Christopher S. Francklyn et al.   METHODS

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA