Molecular matchmaking between the popular weight-loss herbHoodia gordoniiand GPR119, a potential drug target for metabolic disorder

Is GPR119 agonism an appropriate treatment modality for the safe amelioration of metabolic diseases?

(2013) Lauren M Cornall et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Assembly of Naturally Occurring Glycosides, Evolved Tactics, and Glycosylation Methods

(2012) Biao Yu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Expeditious synthesis of saponin P57, an appetite suppressant from Hoodia plants

(2012) Jian Zhang et al.   CHEMICAL COMMUNICATIONS

Cultivation practices and manufacturing processes to produce Hoodia gordonii extract for weight management products

(2012) Tamsin L. Knight et al.   FOOD AND CHEMICAL TOXICOLOGY

5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion

(2011) Ryouta Kogure et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Implications of Obesity for Drug Therapy: Limitations and Challenges

(2011) R Jain et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

New Drug Targets for the Treatment of Obesity

(2011) A G Powell et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In vitro transport of the steroidal glycoside P57 from Hoodia gordonii across excised porcine intestinal and buccal tissue

(2011) I. Vermaak et al.   PHYTOMEDICINE

Hoodia gordonii:An Up-to-Date Review of a Commercially Important Anti-Obesity Plant

(2011) Ilze Vermaak et al.   PLANTA MEDICA

Bioavailability, Pharmacokinetics, and Tissue Distribution of the Oxypregnane Steroidal Glycoside P57AS3 (P57) fromHoodia gordoniiin Mouse Model

(2010) Vamsi Madgula et al.   PLANTA MEDICA

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

(2009) Hong Lan et al.   JOURNAL OF ENDOCRINOLOGY

A protocol for islet isolation from mouse pancreas

(2009) Dong-Sheng Li et al.   Nature Protocols

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

(2009) Bo Ahrén   NATURE REVIEWS DRUG DISCOVERY

GPR119: “Double-Dipping” for Better Glycemic Control

(2008) L. Lauffer et al.   ENDOCRINOLOGY

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

(2008) Zhi-Liang Chu et al.   ENDOCRINOLOGY

Hoodia gordonii: A natural appetite suppressant

(2008) F.R. van Heerden   JOURNAL OF ETHNOPHARMACOLOGY

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

(2008) Graeme Semple et al.   JOURNAL OF MEDICINAL CHEMISTRY