Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 33, Pages E3476-E3485Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1401883111
Keywords
system identification; optimal control; respiratory sinus arrhythmia
Categories
Funding
- Air Force Office of Scientific Research
- National Science Foundation
- Pfizer
- National Institutes of Health [R01 GM078992]
- Institute of Collaborative Biotechnologies [ARO W911NF-09-D-0001]
- John G. Braun Professorship
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [1359814] Funding Source: National Science Foundation
Ask authors/readers for more resources
The correlation of healthy states with heart rate variability (HRV) using time series analyses is well documented. Whereas these studies note the accepted proximal role of autonomic nervous system balance in HRV patterns, the responsible deeper physiological, clinically relevant mechanisms have not been fully explained. Using mathematical tools from control theory, we combine mechanistic models of basic physiology with experimental exercise data from healthy human subjects to explain causal relationships among states of stress vs. health, HR control, and HRV, and more importantly, the physiologic requirements and constraints underlying these relationships. Nonlinear dynamics play an important explanatory role-most fundamentally in the actuator saturations arising from unavoidable tradeoffs in robust homeostasis and metabolic efficiency. These results are grounded in domain-specific mechanisms, tradeoffs, and constraints, but they also illustrate important, universal properties of complex systems. We show that the study of complex biological phenomena like HRV requires a framework which facilitates inclusion of diverse domain specifics (e.g., due to physiology, evolution, and measurement technology) in addition to general theories of efficiency, robustness, feedback, dynamics, and supporting mathematical tools.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available