Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation

Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection

(2013) Cheryl Y. Chan et al.   IMMUNITY

Allosteric Coupling in the Bacterial Adhesive Protein FimH

(2013) Victoria B. Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and energetic basis of folded-protein transport by the FimD usher

(2013) Sebastian Geibel et al.   NATURE

Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

(2013) Nicolas Dreux et al.   PLoS Pathogens

Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia coli Catheter-Associated Urinary Tract Infections in Mice

(2012) Pascale S. Guiton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Both Host and Pathogen Factors Predispose to Escherichia coli Urinary-Source Bacteremia in Hospitalized Patients

(2012) J. Marschall et al.   CLINICAL INFECTIOUS DISEASES

Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic Escherichia coli

(2012) Kimberly A. Kline et al.   INFECTION AND IMMUNITY

Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine

(2012) E. Volkan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Comparative Genomics of Escherichia coli Strains Causing Urinary Tract Infections

(2011) Rebecca Munk Vejborg et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists

(2011) Oliver Schwardt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Type 1 Fimbrial Adhesin FimH Elicits an Immune Response That Enhances Cell Adhesion of Escherichia coli

(2011) Veronika Tchesnokova et al.   INFECTION AND IMMUNITY

Population Dynamics and Niche Distribution of Uropathogenic Escherichia coli during Acute and Chronic Urinary Tract Infection

(2011) Drew J. Schwartz et al.   INFECTION AND IMMUNITY

Fimbrial Profiles Predict Virulence of Uropathogenic Escherichia coli Strains: Contribution of Ygi and Yad Fimbriae

(2011) Rachel R. Spurbeck et al.   INFECTION AND IMMUNITY

Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?

(2011) Birgit Stattin Norinder et al.   MICROBIAL PATHOGENESIS

Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate

(2011) Gilles Phan et al.   NATURE

Insights into a Multidrug Resistant Escherichia coli Pathogen of the Globally Disseminated ST131 Lineage: Genome Analysis and Virulence Mechanisms

(2011) Makrina Totsika et al.   PLoS One

The Bacterial Fimbrial Tip Acts as a Mechanical Force Sensor

(2011) Pavel Aprikian et al.   PLOS BIOLOGY

Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

(2010) Isolde Le Trong et al.   CELL

Donor strand exchange and conformational changes during E. coli fimbrial formation

(2010) Isolde Le Trong et al.   JOURNAL OF STRUCTURAL BIOLOGY

Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection

(2010) Bryndís Ragnarsdóttir et al.   PLoS One

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Severe Inflammatory Responses to Uropathogenic E. coli Predispose to Chronic and Recurrent Urinary Tract Infection

(2010) Thomas J. Hannan et al.   PLoS Pathogens

Prospective Cohort Study of Microbial and Inflammatory Events Immediately PrecedingEscherichia coliRecurrent Urinary Tract Infection in Women

(2009) C. A. Czaja et al.   JOURNAL OF INFECTIOUS DISEASES

A murine model of urinary tract infection

(2009) Chia-Suei Hung et al.   Nature Protocols

Toll-Like Receptor Polymorphisms and Susceptibility to Urinary Tract Infections in Adult Women

(2009) Thomas R. Hawn et al.   PLoS One

Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding

(2009) Swaine L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation

(2008) Olga Yakovenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY