Article
Chemistry, Multidisciplinary
Jieyu Qi, Liyan Zhang, Fangzhi Tan, Yang Zhang, Yinyi Zhou, Ziyu Zhang, Hongyang Wang, Chaorong Yu, Lulu Jiang, Jiancheng Liu, Tian Chen, Lianqiu Wu, Shanzhong Zhang, Sijie Sun, Shan Sun, Ling Lu, Qiuju Wang, Renjie Chai
Summary: This study demonstrates the effectiveness and safety of OTOF gene therapy drugs in mice and nonhuman primates. The researchers developed a new strategy to deliver OTOF and successfully restored hearing in mice with profound deafness. The therapy also showed no impact on normal hearing and systemic toxicity in both mice and nonhuman primates.
Article
Immunology
Kirill Nemirov, Pierre Authie, Philippe Souque, Fanny Moncoq, Amandine Noirat, Catherine Blanc, Maryline Bourgine, Laleh Majlessi, Pierre Charneau
Summary: Dengue virus (DENV) is a major cause of dengue fever, including severe forms such as hemorrhagic dengue and dengue shock syndrome. Despite intensive vaccine research, a universally accepted vaccine against dengue fever has not been developed yet. This study developed a tetravalent T-cell vaccine candidate against DENV, which showed significant protective effects against all four DENV serotypes in a preclinical infection model.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Srinivas Kammanadiminti, Jason Comer, Gabriel Meister, Trevor Carnelley, Derek Toth, Shantha Kodihalli
Summary: In order to meet the requirements of the Animal Rule, the efficacy of monotherapy with ANTHRASIL was evaluated in blinded studies using rabbit and nonhuman primate models. The studies demonstrated that ANTHRASIL significantly improved survival rates in both animals, forming the basis for its approval by the FDA under the Animal Rule.
Review
Immunology
Kassandra L. Carpio, Alan D. T. Barrett
Summary: The Flavivirus genus includes many important human pathogens, with NS1 protein playing a crucial role as a diagnostic marker for flavivirus infection. Its roles in disease pathogenesis and protective immunity make NS1 an excellent target for candidate vaccines.
Article
Gastroenterology & Hepatology
Michael J. Nash, Evgenia Dobrinskikh, Rachel C. Janssen, Mark A. Lovell, Deborah A. Schady, Claire Levek, Kenneth L. Jones, Angelo D'Alessandro, Paul Kievit, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Jacob E. Friedman, Stephanie R. Wesolowski
Summary: Maternal consumption of a Western-style diet during pregnancy can lead to hepatic injury and steatosis in fetal offspring, and postweaning exposure to a Western-style diet can worsen this effect. These effects include the occurrence of liver fibrosis and endoplasmic reticulum stress, making the development of pediatric NAFLD more severe.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Agriculture, Dairy & Animal Science
Sabrina Brando, Augusto Vitale, Madison Bacon
Summary: Ensuring the welfare of primates requires planning complex environments and enrichment activities from a 24-hour perspective, tailored to the species and individual needs. It is important to recognize that animals' care needs may differ during night hours when care staff are absent, and additional measures may be required. This review highlights the importance of focusing on primate welfare during off-hours, addressing relevant topics and utilizing technologies to assess and promote wellbeing at these times.
Review
Biochemistry & Molecular Biology
Elena S. B. Campbell, Melanie M. Goens, Wenguang Cao, Brad Thompson, Leonardo Susta, Logan Banadyga, Sarah K. Wootton
Summary: Monoclonal antibodies (mAbs) are crucial in preventing and treating infectious diseases, especially when vaccines or therapies are lacking. Recent developments in mAb gene cloning have resulted in highly potent mAbs against various pathogens. Adeno-associated virus (AAV) vectors have been explored as a platform for delivering mAb genes, but further optimization is needed for improved therapeutic efficacy. This review summarizes the current landscape of AAV vectored immunoprophylaxis (VIP) in nonhuman primate (NHP) models and discusses major obstacles and implications for clinical translation.
Article
Multidisciplinary Sciences
Nadege Sarrazin, Estelle Chavret-Reculon, Corinne Bachelin, Mehdi Felfli, Rafik Arab, Sophie Gilardeau, Elena Brazhnikova, Elisabeth Dubus, Lydia Yaha-Cherif, Jean Lorenceau, Serge Picaud, Serge Rosolen, Pierre Moissonnier, Pierre Pouget, Anne Baron-Van Evercooren
Summary: This study focuses on the long-term effects of toxin-induced demyelination of the macaque optic nerve and its impact on remyelination, axon preservation, and visual functions. The findings reveal visual impairment, including damage to the optic nerve and retina. This nonhuman primate model replicates key features of multiple sclerosis lesions, making it valuable for studying new therapeutic approaches.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Imran J. Anwar, Isabel DeLaura, Joseph Ladowski, Qimeng Gao, Stuart J. Knechtle, Jean Kwun
Summary: Aberrant activation of the complement system contributes to solid-organ graft dysfunction and failure, particularly in kidney transplantation. Various mechanisms of rejection in kidney transplantation involve the complement system, which has led to the exploration of complement inhibitors as potential therapeutic options. However, the complexity of the system makes it challenging to fully understand and target for treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Eva Andres-Mateos, Lukas D. Landegger, Carmen Unzu, Jean Phillips, Brian M. Lin, Nicholas A. Dewyer, Julio Sanmiguel, Fotini Nicolaou, Michelle D. Valero, Kathrin Bourdeu, William F. Sewell, Rudolph J. Beiler, Michael J. McKenna, Konstantina M. Stankovic, Luk H. Vandenberghe
Summary: The study demonstrates the feasibility and efficiency of using AAV vectors, specifically Anc80L65, for gene therapy in nonhuman primate models of hearing and balance disorders. The results suggest that Anc80L65 achieves higher levels of cochlear gene transfer compared to AAV1, motivating further studies in human patients.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Jiawu Wan, Ting Wang, Jing Xu, Tao Ouyang, Qianruo Wang, Yanni Zhang, Shiqi Weng, Yihan Li, Yu Wang, Xiu Xin, Xiaoling Wang, Sha Li, Lingbao Kong
Summary: LTB-NS1(Delta)(63) demonstrates strong immunogenicity and shows promising results as an oral vaccine in mice. This protein-based mucosa vaccine could serve as a novel approach to combat Japanese encephalitis virus and other flaviviruses effectively.
Review
Cell Biology
Ov D. Slayden, Fangzhou Luo, Cecily Bishop
Summary: Therapies targeting progesterone action have potential for contraception and managing gynecological disorders. Steroid hormones play a role in regulating the mammalian oviduct, with estrogen stimulating epithelial differentiation and progesterone suppressing ciliation and secretion. Nonhuman primates exhibit different hormonal patterns, with progesterone driving fallopian tube cycles. Synthetic progesterone receptor modulators disrupt the normal cyclic regulation of the tube, affecting various factors including receptor expression and cilia activity. Understanding progesterone's role in NHP oviduct is crucial for advancing PRMs as pharmaceutical therapies.
Article
Cell Biology
Shuai Ma, Shuhui Sun, Jiaming Li, Yanling Fan, Jing Qu, Liang Sun, Si Wang, Yiyuan Zhang, Shanshan Yang, Zunpeng Liu, Zeming Wu, Sheng Zhang, Qiaoran Wang, Aihua Zheng, Shuguang Duo, Yang Yu, Juan Carlos Izpisua Belmonte, Piu Chan, Qi Zhou, Moshi Song, Weiqi Zhang, Guang-Hui Liu
Summary: The research indicates that aging is associated with increased systemic inflammation and compromised virus defense in the cardiopulmonary system. With age, expression of the SARS-CoV-2 receptor ACE2 increases, while the accumulation of the cytokine IL7 induces ACE2 expression. Treatment with vitamin C can block IL7-induced ACE2 expression, suggesting that geroprotective strategies may reduce the severity of COVID-19 in the elderly.
Article
Neurosciences
Cristina Banuelos, Joshua R. Kittleson, Katherine H. Lanasa, Christina S. Galiano, Stephanie M. Roth, Evelyn J. Perez, Jeffrey M. Long, Mary T. Roberts, Sania Fong, Peter R. Rapp
Summary: This study found that the GABAergic component of the primate basal forebrain is more vulnerable to aging, leading to a potential loss of inhibitory drive to cortical circuitry. Adaptive reorganization of the GABAergic circuitry may contribute to successful neurocognitive outcomes in aging.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Na Li, Cheng-Lin Deng, Qi Li, Xiao-Ling Chen, Bo Zhang, Han-Qing Ye
Summary: High titers of replication-defective ZIKV with NS1 deletion (ZIKV-Delta NS1) were generated using the NS1 transcomplementation system. ZIKV-Delta NS1 vaccine induced antibody responses and provided protection against ZIKV infection in mice. Moreover, ZIKV-Delta NS1 vaccination attenuated vertical transmission during pregnancy. These findings highlight the potential of the NS1 trans-complementation system for developing flavivirus vaccines.
ANTIVIRAL RESEARCH
(2023)