Article
Plant Sciences
Kosaku Masuda, Tatsuya Yamada, Yuya Kagawa, Hirokazu Fukuda
Summary: Research has shown that plants are able to adjust their circadian rhythms and growth under the influence of time lag, which is related to temperature cycles. By measuring the rhythm of circadian clock genes, a method to estimate the effects of time lag has been established.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biology
Suil Kim, Douglas G. McMahon
Summary: This study reveals that light input to the SCN can change the waveform of molecular clockworks, marking clock advances and delays at simulated dawn and dusk. The changes in waveform seem to be greatest in the ventrolateral SCN, while the effects on period are greatest in the dorsomedial SCN, suggesting spatiotemporally distinct responses within the SCN neural network.
Article
Multidisciplinary Sciences
Kosaku Masuda, Isao T. Tokuda, Norihito Nakamichi, Hirokazu Fukuda
Summary: Circadian clocks enable organisms to synchronize physiological processes with diurnal variations, with the phase response curve being a key tool to understand clock entrainment. This study demonstrates that fundamental properties of the curve can be recovered from the singularity response, which can be easily measured by applying a single stimulus to a desynchronized cellular network. The method is simple, accurate, and applicable to other coupled oscillator systems, offering potential to study circadian clock entrainment in plants and other species in a cost-effective manner.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Anna Ashton, Russell G. Foster, Aarti Jagannath
Summary: Circadian rhythms are essential for survival, allowing organisms to predict environmental changes and time behavior. The circadian clock is a self-sustaining molecular oscillator that needs to be continually adjusted to stay in alignment with the external world. Light is the primary time cue in mammals and plays a complex role in entraining the circadian clock in the SCN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Melissa A. St Hilaire, Maria L. Amundadottir, Shadab A. Rahman, Shantha M. W. Rajaratnam, Melanie Ruger, George C. Brainard, Charles A. Czeisler, Marilyne Andersen, Joshua J. Gooley, Steven W. Lockley
Summary: This study investigates the contributions of different wavelengths of monochromatic light to human melatonin suppression and circadian resetting responses. The results show that, initially, short-wavelength (S) cones and long- and medium-wavelength (L+M) cones have a significant contribution, while the contribution of melanopsin-containing intrinsically-photosensitive retinal ganglion cells (ipRGCs) becomes dominant over time. The first few minutes of light exposure play a crucial role in the phase resetting response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Andrew Salazar, Joerg von Hagen
Summary: Periodically oscillating biological processes, such as circadian rhythms, play a crucial role in tissue pathology, organismal health, and molecular mechanisms. Recent reports challenge the prevailing hierarchical model by suggesting that light can independently affect peripheral circadian clocks. However, there is a lack of comprehensive overview regarding these processes in the skin. This review highlights the molecular circadian clock machinery and factors governing it, and emphasizes the link between circadian rhythm, immunological processes, and skin homeostasis as well as its impact on the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Chenzhong Wang, Yueqi Zhang, Zhe Wang, Wei Yu, Minji Tong, Zuoqin Yan
Summary: This study investigates the role of HIF1 alpha in regulating the core clock in chondrocytes and its impact on the circadian rhythm. The results demonstrate that HIF1 alpha is involved in resetting the molecular clock in chondrocytes through its interaction with the Per2 promoter. Additionally, DMOG treatment shows potential as a supportive therapy for osteoarthritis by ameliorating the severity of the condition caused by jet lag in a DMM model.
Article
Multidisciplinary Sciences
Vojtech Kumpost, Daniela Vallone, Srinivas Babu Gondi, Nicholas S. Foulkes, Ralf Mikut, Lennart Hilbert
Summary: The circadian clock is a cellular mechanism that synchronizes biological processes with the time of day, with external light cues influencing its dynamics. Zebrafish-derived cell cultures provide a laboratory model for circadian entrainment due to their direct light-entrainable clocks. A stochastic oscillator model of the zebrafish circadian clock accurately predicts entrainment dynamics and changes in single-cell oscillator parameters, paving the way for large-scale screens to modify circadian clock function.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Charlotte von Gall
Summary: Life on earth has evolved with an internal clock that generates 24-hour rhythms to anticipate environmental changes. Light plays a crucial role in regulating rhythmic behavior and brain function, especially in nocturnal laboratory rodents. Research has made significant progress in understanding the molecular circadian clockwork and light perception, and the complex interaction between different components of the mammalian circadian system. This review also briefly discusses the impact of light at night, genetic manipulation, and neurodegenerative diseases on the circadian system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lewin Small, Leonidas S. Lundell, Jo Iversen, Amy M. Ehrlich, Morten Dall, Astrid L. Basse, Emilie Dalbram, Ann N. Hansen, Jonas T. Treebak, Romain Barres, Juleen R. Zierath
Summary: Seasonal light affects energy metabolism by modulating the rhythmicity of food intake, rather than melatonin.
Article
Genetics & Heredity
Clara Lorber, Solene Leleux, Ralf Stanewsky, Angelique Lamaze
Summary: This study investigates the relationship between environmental input and the phase of behavior, as well as their effects on the molecular clock and neuronal network. The results show that the effects of different environmental cues on clock entrainment and activity phase can be separated. The findings are important for further understanding how animals adapt their behavior to environmental changes using their circadian clock.
Article
Neurosciences
Vendula Luzna, Pavel Houdek, Karolina Liska, Alena Sumova
Summary: During fetal development, maternal signaling can impact the developing clock in the suprachiasmatic nuclei. Disruption of maternal signaling due to disturbances in the light/dark cycle can lead to changes in gene expression profiles in the fetal SCN. The fetal SCN is highly sensitive to various changes in maternal signaling related to environmental disturbances, showing gene-specific responses.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Ting Huang, Yao Shui, Yue Wu, Xilin Hou, Xiong You
Summary: This study developed a computational approach to investigate the effects of light quality on plant circadian rhythms. The results demonstrated that red light can reset the expression patterns, periods, and phases of the circadian clock, leading to potential applications in high-quality and efficient breeding. Optimizing light quality conditions can also enhance plant growth.
Article
Plant Sciences
Bruce M. Rhodes, Hamad Siddiqui, Safina Khan, Paul F. Devlin
Summary: The red-light regulated transcription factors FHY3 and FAR1 play a key role in positively regulating gene expression in the plant circadian clock. However, the fhy3 mutant shows a red light-specific disruption of rhythmicity that is inconsistent with this role. Our findings suggest that FHY3 may interact with HY5 to modulate CCA1 activity, leading to the red-specific circadian phenotype of fhy3.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Ashleigh G. Wilcox, R. Sonia Bains, Debbie Williams, Elizabeth Joynson, Lucie Vizor, Peter L. Oliver, Elizabeth S. Maywood, Michael H. Hastings, Gareth Banks, Patrick M. Nolan
Summary: The study describes a mouse mutant with the central pacemaker SCN genetically ablated, leading to arrhythmicity in circadian rhythms and metabolic parameters, although the mutants could still anticipate food availability. Despite disruptions to SCN cell identity and circuitry, the mutants' activity levels were altered and other zeitgebers could not restore rhythmicity.
Article
Neurosciences
James Park, Haisun Zhu, Sean O'Sullivan, Babatunde A. Ogunnaike, David P. Weaver, James S. Schwaber, Rajanikanth Vadigepalli
FRONTIERS IN NEUROSCIENCE
(2016)
Article
Biology
David R. Weaver, Vincent van der Vinne, E. Lela Giannaris, Thomas J. Vajtay, Kristopher L. Holloway, Christelle Anaclet
JOURNAL OF BIOLOGICAL RHYTHMS
(2018)
Article
Biology
Vincent van der Vinne, Mark J. Bingaman, David R. Weaver, Steven J. Swoap
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Review
Cell Biology
Elizabeth A. Yu, David R. Weaver
Article
Endocrinology & Metabolism
Sohan Punia, Kyle K. Rumery, Elizabeth A. Yu, Christopher M. Lambert, Abner L. Notkins, David R. Weaver
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2012)
Article
Biology
Robert Dallmann, Jason P. DeBruyne, David R. Weaver
JOURNAL OF BIOLOGICAL RHYTHMS
(2011)
Article
Biology
Jason P. DeBruyne, David R. Weaver, Robert Dallmann
JOURNAL OF BIOLOGICAL RHYTHMS
(2014)
Article
Medicine, Research & Experimental
Erik S. Musiek, Miranda M. Lim, Guangrui Yang, Adam Q. Bauer, Laura Oi, Yool Lee, Jee Hoon Roh, Xilma Ortiz-Gonzalez, Joshua T. Dearborn, Joseph P. Culver, Erik D. Herzog, John B. Hogenesch, David F. Wozniak, Krikor Dikranian, Benoit I. Giasson, David R. Weaver, David M. Holtzman, Garret A. FitzGerald
JOURNAL OF CLINICAL INVESTIGATION
(2013)
Article
Multidisciplinary Sciences
Jean-Pierre Etchegaray, Elizabeth A. Yu, Premananda Indic, Robert Dallmann, David R. Weaver
Article
Multidisciplinary Sciences
Joseph LeSauter, Christopher M. Lambert, Margaret R. Robotham, Zina Model, Rae Silver, David R. Weaver
Article
Multidisciplinary Sciences
Haisun Zhu, Rajanikanth Vadigepalli, Rachel Rafferty, Gregory E. Gonye, David R. Weaver, James S. Schwaber
Article
Multidisciplinary Sciences
Hyeong-Min Lee, Rongmin Chen, Hyukmin Kim, Jean-Pierre Etchegaray, David R. Weaver, Choogon Lee
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Endocrinology & Metabolism
Vincent van der Vinne, Blanca Martin Burgos, Mary E. Harrington, David R. Weaver
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Gastroenterology & Hepatology
Kyle Stokes, Abrial Cooke, Hanna Chang, David R. Weaver, David T. Breault, Phillip Karpowicz
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2017)