Article
Oncology
Emrah Celtikci, Muammer Melih Sahin, Mustafa Caglar Sahin, Emetullah Cindil, Zuhal Demirtas, Hakan Emmez
Summary: This retrospective study aimed to determine the necessity of intraoperative MRI scans following endoscopic endonasal pituitary adenoma surgery. The results show that for adenomas limited in the sellae and not invading the cavernous sinus, an IO-MRI scan is not necessary, but it is strongly recommended if there is any suprasellar and parasellar extension and/or cavernous sinus invasion.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neurosciences
Tianshun Feng, Yi Fang, Zhijie Pei, Ziqi Li, Hongjie Chen, Pengwei Hou, Liangfeng Wei, Renzhi Wang, Shousen Wang
Summary: This study demonstrates the potential of a CNN model to accurately assess sellar floor invasion in pituitary adenoma, with high accuracy and excellent performance.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chun-Qiu Su, Bin-Bin Wang, Wen-Tian Tang, Chao Tao, Peng Zhao, Min-Hong Pan, Xun-Ning Hong, Wen-Tao Hu, Yong-Ming Dai, Hai-Bin Shi, Shan-Shan Lu
Summary: This study evaluated the ability of diffusion-relaxation correlation spectrum imaging (DR-CSI) to predict the consistency and extent of resection (EOR) of pituitary adenomas (PAs). DR-CSI was found to be a promising tool for predicting the consistency and extent of resection of PAs, which has clinical relevance.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Rupa G. Juthani, Anne S. Reiner, Ankur R. Patel, Aimee Cowan, Marie Roguski, Katherine S. Panageas, Eliza B. Geer, Sasan Karimi, Marc A. Cohen, Viviane Tabar
Summary: The study evaluated the safety and efficacy of iMRI for pituitary adenoma resection, comparing endoscopic transsphenoidal and microscopic transsphenoidal approaches. Results showed that iMRI can improve the extent of resection for pituitary adenomas while preserving hormone function, with low rates of postoperative complications.
JOURNAL OF NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Bai, Yu Shen, Rushi Chen, Xianchang Zhang, Mathias Nittka, Gregor Koerzdoerfer, Qiyong Gong, Meiyun Wang
Summary: Magnetic resonance fingerprinting (MRF) can effectively differentiate gonadotroph from non-gonadotroph pituitary macroadenomas, guiding treatment decisions.
EUROPEAN RADIOLOGY
(2021)
Review
Clinical Neurology
John J. Y. Zhang, Jia Xu Lim, Keng Siang Lee, Ramez W. Kirollos, Jai Prashanth Rao
Summary: The use of iMRI in transsphenoidal surgery significantly improves the gross total resection (GTR) rate and achieves comparable benefits for functioning and nonfunctioning pituitary adenomas. Satisfactory endocrinologic and visual outcomes are also achieved.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Huijian Zhang, Shuai Zhang, Mingchao Shang, Jiaxing Wang, Liangfeng Wei, Shousen Wang
Summary: This study aimed to investigate the MRI findings and clinical significance of pituitary stalk position and morphology changes following transsphenoidal surgery for pituitary adenoma (PA). A total of 108 patients who underwent transsphenoidal surgery were included, and the diameter, length, and coronal deviation of the pituitary stalk were measured pre-operatively, post-operatively, and in the mid-term postoperative period. The results showed that the pituitary stalk could be stretched to a normal state after surgery and its position tended to gradually center. The length of the pituitary stalk also gradually increased postoperatively. The presence of posterior pituitary bright spots (PPBS) in the early postoperative period was negatively correlated with postoperative diabetes insipidus (DI).
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Lea M. Alhilali, Andrew S. Little, Kevin C. J. Yuen, Jae Lee, Timothy K. Ho, Saeed Fakhran, William L. White
Summary: In this study of 102 patients undergoing microscopic transsphenoidal resection of a pituitary adenoma, early postoperative MRI showed high sensitivity and specificity for detecting residual tumors, with better reliability than late postoperative MRI. Early MRI identified 4 residual tumors that were missed by intraoperative assessment and late MRI, providing important guidance for reoperation in select patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Yi Fang, He Wang, Ming Feng, Hongjie Chen, Wentai Zhang, Liangfeng Wei, Zhijie Pei, Renzhi Wang, Shousen Wang
Summary: In this study, a CNN model was used to assess cavernous sinus invasion (CSI) in pituitary adenoma (PA), and it showed a high proficiency in diagnosis compared to the traditional Knosp grading system.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Kunzhe Lin, Ran Zeng, Shuwen Mu, Yinghong Lin, Shousen Wang
Summary: This study developed a nomogram to predict delayed hyponatremia after transsphenoidal surgery for pituitary adenoma. By incorporating clinical variables and magnetic resonance imaging scans, the nomogram provides individualized prediction and demonstrates clinical usefulness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Zhang, Junkai Zheng, Zhouyang Huang, Yuen Teng, Chaoyue Chen, Jianguo Xu
Summary: This study aimed to investigate whether morphological changes and delta-radiomics of the optic chiasm obtained from routine MRI could help predict postoperative visual recovery of pituitary adenoma patients. A total of 130 patients were enrolled, and it was found that postoperative morphological changes of the optic chiasm were not significantly associated with visual outcome, while the delta-radiomics model showed good performance in predicting visual recovery.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Martin Cerny, Jan Kybic, Martin Majovsky, Vojtech Sedlak, Karin Pirgl, Eva Misiorzova, Radim Lipina, David Netuka
Summary: This study developed a fully automated system for pituitary adenoma segmentation from MRI scans. Two artificial neural networks were trained on 394 patient scans, and achieved good results on the largest dataset to date. The system demonstrated accuracy and utility for clinical applications, and discussion of future clinical use was included.
NEUROSURGICAL REVIEW
(2023)
Article
Oncology
Kiyohisa Kamimura, Masanori Nakajo, Manisha Bohara, Daigo Nagano, Yoshihiko Fukukura, Shingo Fujio, Tomoko Takajo, Kazuhiro Tabata, Takashi Iwanaga, Hiroshi Imai, Marcel Dominik Nickel, Takashi Yoshiura
Summary: A study investigated the predictive value of quantitative pharmacokinetic analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in determining the consistency of pituitary adenomas. The volume of extravascular extracellular space per unit volume of tissue derived from DCE-MRI was found to have predictive value for consistency of pituitary adenomas, with a positive correlation with histopathologic collagen content. The study suggests that this parameter can be useful for planning transsphenoidal surgery for pituitary adenomas.
Article
Clinical Neurology
Nicholas Chang, Jessica W. Grayson, Joao Mangussi-Gomes, Sebastian Fung, Raquel Alvarado, Mark Winder, Benjamin P. Jonker, Ann McCormack, Richard J. Harvey
Summary: This study aimed to assess the diagnostic performance of four MRI criteria in diagnosing cavernous sinus invasion by pituitary tumors. The Knosp criteria, percentage encasement of the internal carotid (PEICA), and venous compartment obliteration (VCO) were found to be the most effective indicators of CSI, while the presence of certain signs indicated a lower likelihood of CSI. Alternatives to the Knosp criteria, such as PEICA and VCO, can aid in the diagnosis of CSI.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Oncology
Mengyue Huang, Mengna Huang, Xuemei Gao, Yong Zhang, Jingliang Cheng, Jinxia Zhu, Caixia Li, Jingjing Liu
Summary: This study retrospectively examined the MRI features of bile duct adenoma. The results showed that bile duct adenoma primarily presents as intraductal growth in the CBD, usually accompanied by bile duct dilatation. Most lesions appear isointense on T1WI, hyperintense on T2WI and DWI, and show moderate enhancement on dynamic enhanced MRI. Infiltrative growth may indicate malignant transformation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neuroimaging
Wei-dong Xu, Han Wang, Qi Wu, Li-Li Wen, Zong-qi You, Bin Yuan, Shu-juan Chen, Han-Dong Wang, Xin Zhang
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2020)
Article
Biochemistry & Molecular Biology
Renxin Yi, Handong Wang, Chulei Deng, Xinyue Wang, Lei Yao, Wenhao Niu, Maoxing Fei, Wangdui Zhaba
BIOSCIENCE REPORTS
(2020)
Article
Neurosciences
Li Zhang, Maoxing Fei, Handong Wang, Yihao Zhu
BRAIN RESEARCH BULLETIN
(2020)
Article
Immunology
Han Wang, Xiao-Ming Zhou, Ling-Yun Wu, Guang-Jie Liu, Wei-Dong Xu, Xiang-Sheng Zhang, Yong-Yue Gao, Tao Tao, Yan Zhou, Yue Lu, Juan Wang, Chu-Lei Deng, Zong Zhuang, Chun-Hua Hang, Wei Li
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Oncology
Yong Wu, Wuting Wei, Linjun Tang, Liangwei Wang
Article
Oncology
Maoxing Fei, Li Zhang, Handong Wang, Yihao Zhu, Wenhao Niu, Ting Tang, Yanling Han
FRONTIERS IN ONCOLOGY
(2020)
Article
Clinical Neurology
Qiang Wang, Han-Dong Wang, Wenhao Niu, Hao Pan
Summary: This study evaluated the prognostic significance of IDH1/2 mutation, 1p/19q codeletion, and MGMT promoter methylation in lower-grade gliomas according to the 2016 WHO classification. Various factors such as age, mutation status were found to be associated with patient outcomes, with single tumor, MGMT promoter methylation, and chemoradiotherapy identified as independent prognostic factors for overall survival.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Correction
Oncology
Jianhong Zhu, Handong Wang, Qing Sun, Xiangjun Ji, Lin Zhu, Zixiang Cong, Yuan Zhou, Huandong Liu, Mengliang Zhou
Article
Biochemistry & Molecular Biology
Ting Tang, Handong Wang, Yanling Han, Hanyu Huang, Wenhao Niu, Maoxing Fei, Yihao Zhu
Summary: The NDRG family plays an important role in glioma, with differential expression potentially impacting patient prognosis and tumor grade. Additionally, NDRGs may be crucial in signal transduction, energy metabolism, and intercellular communication in glioma.
DNA AND CELL BIOLOGY
(2021)
Article
Neurosciences
Jiakai Chen, Handong Wang, Junjun Wang, Wenhao Niu, Chulei Deng, Mengliang Zhou
Summary: Accumulated evidence suggests that NEAT1 promotes glioma progression by acting as a sponge for miR-128-3p. The NEAT1/miR-128-3p/ITGA5 axis is involved in glioma initiation and progression, offering a potential novel strategy for treatment. NEAT1 competitively binds to miR-128-3p to enhance ITGA5 expression, activating the FAK signaling pathway and promoting cell growth in glioma.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, General & Internal
Li-Li Wen, Xiao-Ming Zhou, Sheng-Yin Lv, Jiang Shao, Han-Dong Wang, Xin Zhang
Summary: High-grade aneurysmal subarachnoid hemorrhage is a severe disease with a poor prognosis, where elevated intracranial pressure is a major feature leading to secondary brain injury. This study suggests that a combination therapy of early coiling and subsequent ventricular intracranial pressure monitoring may benefit high-grade patients, with most patients surviving and intracranial pressure maintained within normal range. Delayed cerebral ischemia and Glasgow coma scale were significant predictors of outcome.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Neurosciences
Chulei Deng, Renxin Yi, Maoxing Fei, Tao Li, Yanling Han, Handong Wang
Summary: Traumatic brain injury (TBI) is a major cause of disability and death globally, with accumulating evidence suggesting that endoplasmic reticulum (ER) stress plays a crucial role in its pathogenesis. Naringenin, a natural flavonoid, has been shown to ameliorate TBI-induced secondary brain injury by attenuating ER stress, oxidative stress, and apoptosis, indicating its potential for neuroprotective effects in TBI.
Article
Medicine, General & Internal
Hao Cheng, Guangfu Di, Chao-Chao Gao, Guoyuan He, Xue Wang, Yan-Ling Han, Le-an Sun, Meng-Liang Zhou, Xiaochun Jiang
Summary: The study evaluated the effects of the S1PR1 modulator FTY720 on the neurovascular unit after experimental TBI in mice. FTY720 administration reduced endothelial cell apoptosis, improved BBB permeability, attenuated astrocytes and microglia activation, and increased the survival rate significantly. These findings suggest that FTY720 administration restored the structure of the NVU after experimental TBI by decreasing endothelial cell apoptosis and attenuating the activation of astrocytes, indicating a potential therapeutic strategy for TBI.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Neurosciences
Yihao Zhu, Handong Wang, Maoxing Fei, Ting Tang, Wenhao Niu, Li Zhang
Summary: Smarcd1, when expressed at low levels, promotes cell proliferation, invasion, and chemoresistance in glioblastoma cells, while enhanced expression inhibits tumor malignant phenotypes. The interaction between Smarcd1 and Notch1 forms a crucial feedback loop that regulates glioblastoma malignant phenotypes. Targeting Smarcd1 could be a potential strategy for human glioblastoma treatment.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Li Zhang, Handong Wang
BRAIN RESEARCH BULLETIN
(2020)
