Article
Biochemistry & Molecular Biology
Reyna Penailillo, Stephanie Acuna-Gallardo, Felipe Garcia, Lara J. Monteiro, Gino Nardocci, Mahesh A. Choolani, Matthew W. Kemp, Roberto Romero, Sebastian E. Illanes
Summary: This study investigated the proliferation, migration, and impact on trophoblast invasion capacity of MenSCs under different physiological conditions. The findings suggest a potential role for MenSCs in the implantation process, implying a communication between maternal MenSCs and invading trophoblast cells that could be implicated in the etiology of PE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study reveals that downregulation of EGF can lead to poor trophoblast cell invasion by increasing KISS1 expression, which subsequently contributes to the pathogenesis of preeclampsia.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Oncology
Tiantian Wu, Wannian Yang, Aiqin Sun, Zhixiao Wei, Qiong Lin
Summary: CXC chemokines are small chemotactic and secreted cytokines that are dysregulated in multiple types of cancer and closely correlated with tumor progression. They play crucial roles in promoting angiogenesis, stimulating inflammatory responses, and facilitating tumor metastases. They have the potential to serve as diagnostic and prognostic biomarkers, as well as therapeutic targets for cancer treatment.
Article
Chemistry, Medicinal
Mei-Tsz Su, Ching-Wei Tsai, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai
Summary: This study demonstrates that elevated cellular FN expression in the placenta of preeclamptic patients is associated with the disease, while aspirin inhibits FN expression and reverses FN-mediated trophoblast functions, providing a drug mechanism for disease prevention and a target for preeclampsia intervention.
Article
Developmental Biology
Pingsong Jin, Yijie Zhou, Zheng Liu, Xuehai Chen, Hongbo Qi
Summary: This study investigated the role of Claudin-1 (CLDN1) in trophoblast invasion and endovascular trophoblast (enEVT) differentiation in early-onset preeclampsia (EOPE). The expression and localization of CLDN1 were examined in normal and EOPE placental tissues. Trophoblast invasion and enEVT differentiation were studied using trophoblast cell lines. The results suggest that downregulation of CLDN1 is involved in the pathogenesis of EOPE by regulating trophoblast invasion and enEVT differentiation.
Article
Developmental Biology
Jian Zhao, Haigang Ding, Jinlong Ding, Xiaoliang Shi, Yao He, Hongdan Zhu, Hua Yuan, Tao Zhang, Juan Zhang
Summary: The METTL3-MYLK axis plays an important role in trophoblast invasion.
Review
Cell Biology
Amin Ullah, Jing Zhao, Rajeev K. Singla, Bairong Shen
Summary: This review discusses the role of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of preeclampsia and gestational diabetes mellitus (GDM) and investigates the potential of CXC-based therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Wei Peng, Ying Liu, Hongbo Qi, Qingshu Li
Summary: The study suggests that ACTN4 may play a crucial role in regulating trophoblast proliferation and differentiation in the human placenta during early pregnancy, and dysregulation of this protein may contribute to the pathogenesis of preeclampsia.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Cell Biology
Qian Yang, Yeling Ma, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang, Yan-Ling Wang
Summary: The study demonstrated the crucial role of MNSF beta in regulating trophoblast invasion and fetal development. Lack of MNSF beta led to restricted embryonic growth and fetal loss, primarily due to limited trophoblast invasion. Conjugation with IGF2BP2 stabilized the protein and promoted trophoblast invasion.
CELL PROLIFERATION
(2021)
Article
Immunology
Hong Zou, Qinghua Mao
Summary: The study revealed that circ_0037078 expression level is higher in placental tissues of PE patients compared to normal controls, and knocking down circ_0037078 enhances the proliferation, migration, invasion, and angiogenesis of trophoblast cells. Mechanistically, circ_0037078 functions as a sponge for miR-576-5p, leading to increased expression of IL1RAP, which is targeted by miR-576-5p. Further experiments showed that inhibition of miR-576-5p reversed the effects of circ_0037078 knockdown on trophoblast cell behaviors.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Dan Tang, Li Geng, Jing Ma
Summary: The study found elevated expression of PROX1-AS1 in PE patients' placental tissues and blood samples. Inhibiting PROX1-AS1 promoted cell migration and invasion, regulated apoptosis through interactions with miR-211-5p and caspase-9.
Article
Obstetrics & Gynecology
Mercedes Olaya-C, Marta Garrido, Jorge Andres Franco, Jorge Luis Rodriguez, Magda Jimena Vargas, Ana Aula-Olivar, Laura Quintero, Santiago Ramon Y. Cajal
Summary: Remodeling of uterine spiral arteries is crucial for successful pregnancy, as failure can result in pregnancy complications. The process of arterial remodeling is not synchronous in all vessels, with different stages occurring in a single sample. Muscle and endothelial tissue loss during pregnancy between weeks 14-17 is a key aspect of the remodeling process.
REPRODUCTIVE SCIENCES
(2021)
Review
Anatomy & Morphology
Yu Zhaoer, Gao Mingming, Zhang Wei, Yao Dan, Qian Yating, Jia Ruizhe
Summary: Preeclampsia is a common pregnancy complication that can lead to serious complications and maternal mortality. In recent years, extracellular vesicle therapy has gained attention for its anti-inflammatory, tissue regeneration-promoting, and immunomodulatory properties. This review summarizes recent advances in the use of extracellular vesicles for the treatment of preeclampsia and the involved biological pathways and molecules.
Article
Cell Biology
Asli Ozmen, Ozlem Guzeloglu-Kayisli, Selcuk Tabak, Xiaofang Guo, Nihan Semerci, Chinedu Nwabuobi, Kellie Larsen, Ali Wells, Asli Uyar, Sefa Arlier, Ishani Wickramage, Hasan Alhasan, Hana Totary-Jain, Frederick Schatz, Anthony O. Odibo, Charles J. Lockwood, Umit A. Kayisli
Summary: In preeclampsia, the competition binding of IL-6 and IL-11 to gp130 impairs the function and morphology of extravillous trophoblast cells (EVT), and the reduced expression of ISG15 is associated with this effect.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Developmental Biology
Andreanna Burman, Rolando Garcia-Milian, Madeleine Wood, Natalie A. DeWitt, Vasilis Vasiliou, Seth Guller, Vikki M. Abrahams, Shannon Whirledge
Summary: The use of acetaminophen may interfere with critical trophoblast functions, potentially impacting fetal development.