Article
Biochemistry & Molecular Biology
Pablo C. Caracciolo, Patricia Diaz-Rodriguez, Ines Ardao, David Moreira, Florencia Montini-Ballarin, Gustavo A. Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The study developed bioresorbable small-diameter vascular grafts functionalized with heparin to promote endothelial cell growth and inhibit smooth muscle cells over-proliferation. The tensile properties of the heparin-functionalized vascular grafts resembled those of saphenous veins, indicating potential clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Miaomiao Chai, Mingli Jiang, Ce Gu, Qiaohui Lu, Yi Zhou, Ziyang Jin, Yan Zhou, Wensong Tan
Summary: The study found that the number of HUVECs in the coculture system increased in the growth medium group and decreased in the osteogenic induction medium group; The paracrine effects of MSCs were altered, with PEDF affecting the apoptosis and proliferation of HUVECs through mediation of p53, BAX/BCL-2, FAS, and c-Caspase-3; Silencing of PEDF had an impact on the osteogenic potential of MSCs.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi, Michael Keese
Summary: The study revealed a novel biphasic response of human umbilical vein endothelial cells to blue light illumination. Low fluence blue light promoted cell activities, while high fluence illumination had the opposite effect by upregulating pro-apoptotic signaling pathways. These findings provide insights into photobiomodulation by blue light and potential treatment strategies for angiogenesis-dependent diseases.
Article
Environmental Sciences
Jiajing Cui, Pingwei Wang, Shuqi Yan, Yujun Liang, Dongge Liu, Shuping Ren
Summary: The study aims to explore the role of ferroptosis in endothelial cell dysfunction and its underlying mechanisms.
Article
Biochemistry & Molecular Biology
Ilnur I. Salafutdinov, Dilara Z. Gatina, Maria I. Markelova, Ekaterina E. Garanina, Sergey Yu. Malanin, Ilnaz M. Gazizov, Andrei A. Izmailov, Albert A. Rizvanov, Rustem R. Islamov, Andras Palotas, Zufar Z. Safiullov
Summary: The biosafety of gene therapy is a critical issue in the correction of genetic disorders using recombinant cDNA delivery. This study evaluated the changes in transcriptome and secretome of genetically modified umbilical cord blood mononuclear cells (UCB-MCs) using adenoviral vectors. The results showed efficient expression of transgenes in UCB-MCs and indicated no adverse effects on transcriptome and secretome patterns. This data demonstrates the biosafety of using UCB-MCs as cell carriers for therapeutic genes.
Article
Pharmacology & Pharmacy
Siyu Liu, Rong Hu, Jie Du, Yuanjian Li, Xiaohui Li
Summary: The senescence and dysfunction of vascular endothelial cells are important features of diabetic vascular disease. High mobility group box-1 (HMGB1) may be involved in vascular injury in response to high glucose. Glycyrrhizin (GL) is an HMGB1 inhibitor that significantly reduces HMGB1 and protects blood vessels from damage.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Article
Genetics & Heredity
Regina L. Binz, Rupak Pathak
Summary: This study investigated the cytogenetic integrity of primary human umbilical vein endothelial cells (HUVECs) and found that approximately 50% of the cells have a deletion of the Xq terminal region. Additionally, a similar Xq deletion was identified in the daughter cell line generated by fusing HUVECs with A549 cells.
Article
Pharmacology & Pharmacy
Jun-Hei Chang, Chen-Chuan Cheng, Yen-Yu Lu, Cheng-Chih Chung, Yung-Hsin Yeh, Yao-Chang Chen, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: VEGF reduces PV arrhythmogenesis by modulating sodium/calcium homeostasis through VEGFR-1/NOS signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Chen Shen, Ying Jiang, Qiao Li, Chaofan Liu, Feifei Hu, Ming Li
Summary: The study showed that BMP-7 reduced TGF-beta-induced EndoMT in both in vitro and in vivo models of SSc, potentially serving as a promising antifibrotic therapy for SSc.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Environmental Sciences
Guiyi Gong, Hiotong Kam, Yu-chung Tse, John P. Giesy, Sai-wang Seto, Simon Ming-yuen Lee
Summary: CPPU impairs developmental angiogenesis and vasculature in zebrafish embryos, inhibiting survival, hatching, and vascular structure development. It also disrupts the cytoskeleton in zebrafish embryos and human umbilical vein endothelial cells (HUVECs). Additionally, CPPU affects signaling pathways related to vascular development in HUVECs.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Zixuan Liu, Xiaomin Xia, Xuying Lv, Erqun Song, Yang Song
Summary: Iron-bearing nanoparticles (IBNPs) are abundant in particulate matter (PM) and considered hazardous to human health with unclear toxic mode-of-action. Studies show that IBNPs promote ferroptosis, affecting intracellular iron levels, disrupting cell signaling, causing mitochondrial dysregulation, and activating related genes. This highlights the importance of recognizing the ferroptotic activity of IBNPs for assessing the health risks associated with PM.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemical Research Methods
Lisha Mao, Xiaoqi Yuan, Junlei Su, Yaping Ma, Chaofan Li, Hongying Chen, Fugui Zhang
Summary: Under extreme ischemia conditions, human umbilical vein endothelial cells (HUVECs) rely on ischemic tricarboxylic acid (TCA) cycle instead of glycolysis to keep cells alive, but consideration must be given to relieve cell injury.
JOURNAL OF PROTEOME RESEARCH
(2022)