Article
Biochemistry & Molecular Biology
Toru Kuramoto, Denan Jin, Koji Komeda, Kohei Taniguchi, Fumitoshi Hirokawa, Shinji Takai, Kazuhisa Uchiyama
Summary: The study found that a chymase inhibitor significantly reduced pancreatic neutrophil numbers and inflammation in acute pancreatitis, leading to improved survival rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Wentao Shu, Yinan Wang, Xi Zhang, Chaoyang Li, Hanxiang Le, Fei Chang
Summary: Burn treatment is a challenging clinical issue with the future lying in the development of active dressings such as hydrogel dressings that can accelerate wound healing. Various treatment strategies for burns are reviewed, emphasizing the clinical value of hydrogel dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Immunology
Rida Siddique, Malik Hassan Mehmood, Liaqat Hussain, Abdul Malik, Ayesha Sethi, Maryam Farrukh, Shaneel Kousar
Summary: Burn management is a complex process involving multiple phases of wound healing. The use of medicinal plants and phytochemicals as alternative agents for burn wound management shows promise due to their biocompatibility, cost-effectiveness, and cultural acceptance. This review highlights the therapeutic potential of 35 medicinal herbs and 10 phytochemicals in burn wound healing, including their mechanisms of action such as modulation of inflammatory cytokines and oxidative stress. The review also emphasizes the need for efficacious alternative agents to combat the high cost of synthetic drugs and antibiotic resistance.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cheong Hoon Seo, Hui Song Cui, June-Bum Kim
Summary: This study reveals the pathological role of calpain in post-burn hypertrophic scar formation and the anti-fibrotic effect of calpastatin through calpain inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Verena Schneider, Daniel Kruse, Ives Bernardelli de Mattos, Saskia Zoephel, Kendra-Kathrin Tiltmann, Amelie Reigl, Sarah Khan, Martin Funk, Karl Bodenschatz, Florian Groeber-Becker
Summary: Burns affect millions annually, requiring a detailed model to mimic pathophysiology for better understanding of regeneration. A three-dimensional burn model demonstrated a similar healing process to in vivo over 14 days, offering the opportunity to better understand the physiology of thermal burn wound healing.
Article
Biochemistry & Molecular Biology
Touba Khaliq, Muhammad Sohail, Muhammad Usman Minhas, Syed Ahmed Shah, Nazish Jabeen, Shahzeb Khan, Zahid Hussain, Arshad Mahmood, Mubeen Kousar, Haroon Rashid
Summary: Diabetic wound infection can lead to complications and even death. This study focuses on developing a potential hydrogel membrane dressing loaded with CTX for diabetic burn wound healing. The results show that the formulated membranes have good mechanical strength, barrier properties, and controlled drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Que Bai, Caiyun Zheng, Na Sun, Wenting Chen, Qian Gao, Jinxi Liu, Fangfang Hu, Tong Zhou, Yanni Zhang, Tingli Lu
Summary: This study presents an oxygen-releasing hydrogel that promotes cell survival, migration, and tube formation under hypoxic conditions, and facilitates tissue repair by reducing inflammation, increasing angiogenesis, and collagen deposition.
ACTA BIOMATERIALIA
(2022)
Article
Dermatology
Saranchimeg Enkhtuvshin, Erdenezaya Odkhuu, Khongorzul Batchuluun, Battogtokh Chimeddorj, Enkhtur Yadamsuren, Naranbat Lkhagvasuren
Summary: This study aimed to identify risk factors for post-burn scarring in children aged 0-18 years. A total of 182 participants were followed for 6 months after being diagnosed with upper and lower extremity burns. The degree and location of the burn were found to significantly affect scar development.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biophysics
Karan Razdan, Shashi Kanta, Ekta Chaudhary, Seema Kumari, Deepak Kumar Rahi, Ashok Kumar Yadav, Vivek Ranjan Sinha
Summary: The study developed and characterized levofloxacin-loaded clove oil nanoscale emulgel and evaluated its therapeutic efficacy in Pseudomonas aeruginosa biofilm-infected burn wounds in mice. The results showed that the emulgel dispersed biofilms, closed wounds, promoted re-epithelialization and collagen deposition, and cleared the infection within 7 days, indicating its effectiveness in treating biofilm-infected burn wounds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Agnieszka Surowiecka, Anna Chrapusta, Maria Klimeczek-Chrapusta, Tomasz Korzeniowski, Justyna Drukala, Jerzy Struzyna
Summary: Mesenchymal stem cells have regenerative potential and can be used in the treatment of burn wounds. They secrete growth factors, promote tissue regeneration, and produce exosomes. Cellular therapy can reduce healing time without major side effects. However, due to heterogeneity of studies, it remains an experimental method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guoguang Chen, Yaxin Zhou, Jie Dai, Shiyu Yan, Wenjun Miao, Lili Ren
Summary: A new dressing material that promotes the healing of deep burn wounds has been developed in this study. The material exhibits good biocompatibility and temperature-responsive properties, allowing for rapid drug release to prevent infection, assist in wound contraction, promote tissue regeneration, and reduce scar formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Fateme Fayyazbakhsh, Michael J. Khayat, Ming C. Leu
Summary: This study utilized clinically relevant hydrogels to fabricate 3D-printed dressings for the treatment of deep partial-thickness burn wounds. The findings revealed that a 3D-printed dressing with 75% gelatin and 25% alginate exhibited the best balance between mechanical properties, hydration activity, and in vitro biological response.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Polymer Science
Abdul Qadir, Samreen Jahan, Mohd Aqil, Musarrat Husain Warsi, Nabil A. Alhakamy, Mohamed A. Alfaleh, Nausheen Khan, Athar Ali
Summary: Medicinal plants have been used since ancient times and are gradually proving their effectiveness in modern drug delivery systems, while nanotechnology is emerging as a promising strategy in disease control and shows potential advantages for treating skin burn wounds.
Article
Infectious Diseases
Siqi Zhou, Shuzhen Xiao, Xuedong Wang, Xuefeng Wang, Lizhong Han
Summary: The study aimed to analyze the incidence, factors, and progression of burn wound infection (BWI), including the evolution of bacterial strains. The results showed that burn depth, area, and duration from burn to hospitalization were independent risk factors for BWI. Additionally, Staphylococcus aureus was the most commonly isolated causative organism in patients with BWI.
Article
Dermatology
Chuanming Lin, Liuyan Xin, Shuiling Xie
Summary: A meta-analysis found that platelet-rich plasma (PRP) has significant benefits in the treatment of burn wounds, including improving wound healing rate, shortening wound healing time, reducing the incidence of adverse events, and alleviating patient pain.
INTERNATIONAL WOUND JOURNAL
(2023)