Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 4, Pages 1452-1457Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0910734106
Keywords
recombination; epistasis; additive effects; fitness; genetic architecture
Categories
Funding
- Miller Institute for Basic Research in Science
- National Science Foundation [CCF-0635319, CCF-0646682]
- National Institutes of Health [GM28016]
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [0917026] Funding Source: National Science Foundation
Ask authors/readers for more resources
The assumption that different genetic elements can make separate contributions to the same quantitative trait was originally made in order to reconcile biometry and Mendelism and ever since has been used in population genetics, specifically for the trait of fitness. Here we show that sex is responsible for the existence of separate genetic effects on fitness and, more generally, for the existence of a hierarchy of genetic evolutionary modules. Using the tools developed in the process, we also demonstrate that in terms of their fitness effects, separation and fusion of genes are associated with the increase and decrease of the recombination rate between them, respectively. Implications for sex and evolution theory are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available