Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo

A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes

(2009) E.-S. Sung et al.   MOLECULAR CANCER THERAPEUTICS

An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies

(2009) D. Schonfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a novel anti-human TNF-α murine monoclonal antibody with high binding affinity and neutralizing activity

(2008) Moo-Young Song et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Alternative binding proteins: Biological activity and therapeutic potential of cystine-knot miniproteins

(2008) Harald Kolmar   FEBS Journal

To kill a tumor cell: the potential of proapoptotic receptor agonists

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS