Article
Multidisciplinary Sciences
Debasmita Bhattacharya, Vicky Shah, Oreoluwa Oresajo, Anthony Scime
Summary: This study reveals that the transcriptional co-repressor p107 regulates myogenic progenitor proliferation through repression of mitochondrial transcription and ATP output, establishing a metabolic control mechanism for cell cycle rate in myogenic progenitors.
NATURE COMMUNICATIONS
(2021)
Article
Ophthalmology
Jie Yang, Yongyun Li, Chunyan Zong, Qianqian Zhang, Shengfang Ge, Lei Ma, Jiayan Fan, Jianming Zhang, Renbing Jia
Summary: The study identified xanthatin as an effective inhibitor of retinoblastoma by targeting PLK1-mediated cell cycle progression, inducing cell cycle arrest and apoptosis. The efficacy of xanthatin in inhibiting tumor growth was confirmed in vitro and in vivo, suggesting its potential as a drug treatment for retinoblastoma.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Crisanto Gutierrez
Summary: Cell division cycle is a fundamental process for the perpetuation of organisms, including plants. Studies on plant cell division cycle started with cytological and physiological approaches in the 1950s and 1960s, and later experienced rapid growth with the development of genetics and genomics. Current research not only focuses on understanding the plant cell cycle machinery, but also examines the interaction of cell cycle components with various aspects of plant biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Peihua Li, Shiming Pu, Chao Lin, Liu He, Hongxia Zhao, Cheng Yang, Ziqi Guo, Shisan Xu, Zuping Zhou
Summary: Curcumin exhibits anti-colon cancer properties by inhibiting cell proliferation and inducing apoptosis through p53-mediated mechanisms.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Chang Sik Cho, Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim
Summary: The study established carboplatin-resistant retinoblastoma cell lines, which can be used to investigate chemoresistance in retinoblastoma and develop potential therapeutics.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Chang Sik Cho, Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim
Summary: This study established carboplatin-resistant retinoblastoma cell lines, providing a tool for research on the treatment of chemoresistant retinoblastoma.
MOLECULES AND CELLS
(2022)
Article
Oncology
Yang Pan, Zhiqiang Zhao, Juan Li, Jinsong Li, Yue Luo, Weiyuxin Li, Wanbang You, Yujun Zhang, Zhonghan Li, Jian Yang, Zhi-Xiong Jim Xiao, Yang Wang
Summary: The study reveals that nuclear Beclin 1 plays a role in promoting colorectal cancer growth by modulating RB protein stability. This suggests that nuclear Beclin 1 may serve as a potential prognostic indicator for colorectal cancer.
Article
Oncology
Radoslav Janostiak, Ariadna Torres-Sanchez, Francesc Posas, Eulalia de Nadal
Summary: This review summarizes the recent research on the function and regulation of Rb1. Rb1 is an important tumor suppressor protein that regulates cell cycle and cancer development through post-translational modifications. We discuss potential approaches to design novel anticancer therapies by harnessing these modifications.
Article
Cell Biology
Badri Krishnan, Ioannis Sanidas, Nicholas J. Dyson
Summary: This study found that active forms of RB can cause widespread changes in nuclear architecture, which are not correlated with cell cycle arrest or repression of the E2F transcriptional program. Instead, these changes appear later and are associated with autophagy or senescence markers in IMR-90 cells. This perspective discusses the relative timing of these RB-induced events, the mechanisms underlying RB-induced chromatin dispersion, and the potential connection between dispersion and cell cycle exit.
Article
Biology
Charandeep Singh, Andrew Benos, Allison Grenell, Sujata Rao, Bela Anand-Apte, Jonathan E. Sears
Summary: Supraphysiological concentration of oxygen used in severely premature infants can lead to retinovascular growth attenuation and vasoobliteration, contributing to oxygen-induced retinopathy through Myc-dependent regulation of cell cycle and retinal endothelial cell proliferation.
Article
Cardiac & Cardiovascular Systems
Jiacheng Sun, Lu Wang, Rachel C. Matthews, Gregory P. Walcott, Yu-An Lu, Yuhua Wei, Yang Zhou, Lior Zangi, Jianyi Zhang
Summary: The specific modified mRNA translation system (SMRTs) can induce CCND2 expression in cardiomyocytes, promoting cardiomyocyte proliferation, reducing infarct size, and improving cardiac performance in mammalian hearts with myocardial infarction.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Riham R. E. Abouleisa, Abou Bakr M. Salama, Qinghui Ou, Xian-Liang Tang, Mitesh Solanki, Yiru Guo, Yibing Nong, Lindsey McNally, Pawel K. Lorkiewicz, Kamal M. Kassem, Brooke M. Ahern, Krishna Choudhary, Reuben Thomas, Yu Huang, Hamzah R. Juhardeen, Aisha Siddique, Zainab Ifthikar, Sally K. Hammad, Ayman S. El-Baz, Kathryn N. Ivey, Daniel J. Conklin, Jonathan Satin, Bradford G. Hill, Deepak Srivastava, Roberto Bolli, Tamer M. A. Mohamed
Summary: This study provides mechanistic insights into forced cardiomyocyte proliferation and advances the clinical feasibility of this approach for the treatment of ischemic heart failure by minimizing the oncogenic potential of cell cycle factors and using a novel viral construct.
Article
Ophthalmology
Cong Nie, Huan Ma, Yang Gao, Jinmiao Li, Zhixin Tang, Ying Chen, Rong Lu
Summary: The study explored key pathways and factors in RB pathogenesis, identifying the cell cycle pathway and six relevant genes as potential key factors in RB tumorigenesis.
Article
Oncology
Marion Baniol, Francesca Murganti, Agata Smialowska, Joni Panula, Eniko Lazar, Viveka Brockman, Sarantis Giatrellis, Wouter Derks, Olaf Bergmann
Summary: This study utilized a transgenic mouse model with the FUCCI system to isolate and characterize cycling cardiomyocytes, as well as perform single-cell transcriptome analysis of cardiomyocytes at different developmental stages. The results showed that cardiomyocytes have the highest mitotic activity at birth, followed by a gradual decline during the neonatal period, with premature cell cycle exit at G1/S shortly after birth and delayed G1/S progression during endoreplication. Single-cell RNA-seq confirmed signaling pathways involved in cardiomyocyte proliferation and maturation-related transcriptional changes during postnatal development. The study generated transcriptional profiles specific to cell division and endoreplication in cardiomyocytes at different developmental stages, which may help identify genes important for adult cardiomyocyte proliferation and heart regeneration.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Riham R. E. Abouleisa, Jessica M. Miller, Ahmad Gebreil, Abou Bakr M. Salama, Marc Dwenger, Hania Abdelhafez, Reham M. Wahid, Adeniyi T. Adewumi, Mahmoud E. S. Soliman, Nader E. Abo-Dya, Tamer M. A. Mohamed
Summary: This study identified a small molecule called NDPPC, which can enhance the cell cycle progression of cardiomyocytes and has the potential to be a drug for heart failure treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Upasana Das Adhikari, George Eng, Mara Farcasanu, Laura E. Avena, Manish C. Choudhary, Virginia A. Triant, Meaghan Flagg, Abigail E. Schiff, Isabella Gomez, Leah M. Froehle, Thomas J. Diefenbach, Larance Ronsard, Daniel Lingwood, Grace C. Lee, Seyed Alireza Rabi, Derek Erstad, George Velmahos, Jonathan Z. Li, Richard Hodin, James R. Stone, Anna N. Honko, Anthony Griffiths, Omer H. Yilmaz, Douglas S. Kwon
Summary: This study suggests that the presence of SARS-CoV-2 RNA in stool indicates extrapulmonary dissemination to the gastrointestinal tract, leading to decreased survival in COVID-19 cases. Measurement of SARS-CoV-2 RNA in stool could be useful for assessing clinical risk.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
James P. Pirruccello, Mark D. Chaffin, Elizabeth L. Chou, Stephen J. Fleming, Honghuang Lin, Mahan Nekoui, Shaan Khurshid, Samuel F. Friedman, Alexander G. Bick, Alessandro Arduini, Lu-Chen Weng, Seung Hoan Choi, Amer-Denis Akkad, Puneet Batra, Nathan R. Tucker, Amelia W. Hall, Carolina Roselli, Emelia J. Benjamin, Shamsudheen K. Vellarikkal, Rajat M. Gupta, Christian M. Stegmann, Dejan Juric, James R. Stone, Ramachandran S. Vasan, Jennifer E. Ho, Udo Hoffmann, Steven A. Lubitz, Anthony A. Philippakis, Mark E. Lindsay, Patrick T. Ellinor
Summary: Genome-wide association analyses identified variants associated with thoracic aortic diameter and polygenic score for ascending aortic diameter was correlated with a diagnosis of thoracic aortic aneurysm. Enlargement or aneurysm of the aorta predisposes to dissection, and a deep learning model along with genome-wide association studies successfully identified loci associated with ascending and descending thoracic aortic diameter, highlighting the potential for rapidly defining quantitative traits with deep learning in biomedical images.
Review
Cardiac & Cardiovascular Systems
Cristina Basso, James R. Stone
Summary: Autopsy has played a significant role in advancing our understanding of cardiovascular diseases, providing valuable insights into anatomy, physiology, and pathology. It remains important even in the era of advanced cardiovascular imaging, particularly in cases of sudden unexpected deaths where it may be the only chance to obtain a correct diagnosis. Autopsies also contribute to furthering knowledge on underlying diseases, assessing the effectiveness of imaging modalities, and gaining insights into the natural history and rare presentations of cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2022)
Article
Neurosciences
Lite Yang, Mengyi Xu, Shamsuddin A. Bhuiyan, Jia Li, Jun Zhao, Randall J. Cohrs, Justin T. Susterich, Sylvia Signorelli, Ursula Green, James R. Stone, Dan Levy, Jochen K. Lennerz, William Renthal
Summary: This study developed a cell atlas of trigeminal ganglion cells in humans and mice, providing insights into the gene expression patterns and gene regulatory elements of different cell types. The atlas identified cell types implicated in migraine and provides a valuable resource for understanding headache pathophysiology and developing more selective treatments.
Article
Medicine, General & Internal
David Jayne, John H. Stone, Otto Rapalino, James R. Stone
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Karen L. Kelly, Peter T. Lin, Cristina Basso, Melanie Bois, L. Maximilian Buja, Stephen D. Cohle, Giulia d'Amati, Emily Duncanson, John T. Fallon, Dennis Firchau, Gregory Fishbein, Carla Giordano, Charles Leduc, Silvio H. Litovsky, Shannon Mackey-Bojack, Joseph J. Maleszewski, Katarzyna Michaud, Robert F. Padera, Stavroula A. Papadodima, Sarah Parsons, Stanley J. Radio, Stefania Rizzo, Susan J. Roe, Maria Romero, Mary N. Sheppard, James R. Stone, Carmela D. Tan, Gaetano Thiene, Allard C. van der Wal, John P. Veinot
Summary: Sudden cardiac death is an unexpected death caused by a cardiac condition, accounting for approximately 15-20% of all deaths. It commonly occurs in older adults with acquired heart disease but can also happen in young individuals due to genetic transmission. Investigation of these deaths is crucial due to the potential impact on other family members and the lack of consistent guidelines for cardiac examination in these cases.
CARDIOVASCULAR PATHOLOGY
(2023)
Article
Medicine, General & Internal
Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce Levy, Grace A. McComsey, Lisa McCorkell, Girish N. Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A. Walker, Caitlin A. Selvaggi, Daniel J. Shinnick, Carolin C. M. Schulte, Rachel Atchley-Challenner, Leora I. Horwitz, Andrea S. Foulkes
Summary: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, known as postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID. This study developed a definition of PASC based on self-reported symptoms and described the frequencies of PASC across cohorts, vaccination status, and number of infections.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
James P. Pirruccello, Joel T. Ramo, Seung Hoan Choi, Mark D. Chaffin, Shinwan Kany, Mahan Nekoui, Elizabeth L. Chou, Sean J. Jurgens, Samuel F. Friedman, Dejan Juric, James R. Stone, Puneet Batra, Kenney Ng, Anthony A. Philippakis, Mark E. Lindsay, Patrick T. Ellinor
Summary: Genetic determinants of aortic function influence the risk for stroke and coronary artery disease, and may lead to novel targets for medical intervention.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Oncology
Molly M. M. Wilson, Paul S. S. Danielian, Griffin Salus, Roberta Ferretti, Charles A. A. Whittaker, Jacqueline A. A. Lees
Summary: BMI1 is involved in the self-renewal and proliferation of adult stem cells and tumors, but in cutaneous melanoma, it promotes epithelial-mesenchymal transition and metastasis while having little effect on proliferation or primary tumor growth. Deletion of melanocyte-specific Bmi1 in mice leads to premature hair greying and gradual loss of melanocytes, and depilation accelerates the depletion of melanocyte stem cells, suggesting a protective role of BMI1 against stress in these cells.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Rheumatology
Guy Katz, Sandeep H. Hedgire, James R. Stone, Sebastian Perez-Espina, Ana Fernandes, Cory A. Perugino, Zachary S. Wallace, John H. Stone
Summary: IgG4-related disease is a systemic autoimmune fibroinflammatory disease that can affect multiple organ systems. Coronary artery involvement is an important manifestation of IgG4-RD, causing potential complications such as coronary artery aneurysms, myocardial infarction, and ischemic cardiomyopathy.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Cardiac & Cardiovascular Systems
Vidhya Nair, Gregory A. Fishbein, Robert Padera, Michael A. Seidman, Mathieu Castonguay, Charles Leduc, Carmela D. Tan, E. Rene Rodriguez, Joseph J. Maleszewski, Dylan Miller, Maria Romero, Jon Lomasney, Giulia d'Amati, Monica De Gaspari, Stefania Rizzo, Annalisa Angelini, Cristina Basso, Silvio Litovsky, Louis Maximilian Buja, James R. Stone, John P. Veinot
Summary: Giant cell arteritis (GCA) is the most common systemic vasculitis in adults in Europe and North America, and temporal artery biopsy (TAB) remains the gold standard for diagnosis. To address the lack of uniformity in processing and interpretation of TAB specimens, the Society for Cardiovascular Pathology has established consensus guidelines based on existing literature. The guidelines also discuss differential diagnoses and noninflammatory changes of the temporal artery.
CARDIOVASCULAR PATHOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
James R. Stone
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Immunology
Aram J. Krauson, Faye Victoria C. Casimero, Zakir Siddiquee, James R. Stone
Summary: At the start of the COVID-19 pandemic, the BNT162b2 (BioNTech-Pfizer) and mRNA-1273 (Moderna) mRNA vaccines were designed and produced rapidly. This study found that both vaccines can persist in human tissues for up to 30 days after vaccination. Additionally, the study detected the vaccine in the myocardium of deceased patients who had been vaccinated within 30 days of death.
Article
Medicine, General & Internal
Tanayott R. Thaweethai, Sarah E. Jolley, Elizabeth Karlson, Emily M. Levitan, Bruce Levy, Grace McComsey, Lisa S. McCorkell, Girish D. Nadkarni, Sairam E. Parthasarathy, Upinder J. Singh, Tiffany Walker, Caitlin W. Selvaggi, Daniel Shinnick, Carolin C. M. P. Schulte, Rachel M. Atchley-Challenner, Leora Horwitz, Andrea Foulkes
Summary: This study aims to develop a definition of postacute sequelae of SARS-CoV-2 infection (PASC) using self-reported symptoms and analyze the frequencies of PASC across different cohorts, vaccination status, and number of infections. The results show that PASC is associated with various symptoms and around 10% of participants were PASC positive at 6 months after infection.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Ophthalmology
Marisa Tieger, Upasana Das Adhikari, Shizuo Mukai, Mara Farcasnu, James R. Stone, Dean Eliott, Leo A. Kim, Douglas S. Kwon, Elizabeth J. Rossin
Summary: This study examined the presence of SARS-CoV-2 RNA in the vitreous of autopsy patients with COVID-19 and found that it may pose risks to operating room personnel during ophthalmic surgical procedures.
JOURNAL OF VITREORETINAL DISEASES
(2022)