Article
Genetics & Heredity
Jiabin Huang, Bjoern Voss
Summary: This study introduces a new approach that combines structure abstraction with evolutionary conservation to simplify the simulation analysis of RNA folding kinetics, addressing a long-standing challenge in the field.
Article
Engineering, Aerospace
Victor Parque, Wataru Suzaki, Satoshi Miura, Ayako Torisaka, Tomoyuki Miyashita, Michihiro Natori
Summary: This paper investigates the deployment performance of multiple spiral folding schemes for packaging flat and curved membranes of finite thickness. Experimental results show that the multi-spiral approach with prismatic folding lines offers improved deployment performance and rapid progress in the deployment of curved surfaces. This approach has the potential to extend the versatility and maneuverability of spiral folding mechanisms.
ADVANCES IN SPACE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Eleanor Dickson-Murray, Kenza Nedara, Nazanine Modjtahedi, Kostas Tokatlidis
Summary: Mitochondrial proteins, mostly encoded by nuclear genes, must be precisely targeted and sorted within mitochondria. Protein translocases facilitate this process, with the main import pathway for the intermembrane space chemically modifying imported proteins by introducing disulfide bonds. Mia40 is a key component in this pathway, regulated by redox processes, and plays a crucial role in trapping folded precursors in the intermembrane space.
Article
Biochemistry & Molecular Biology
Flavien Zannini, Johannes M. Herrmann, Jeremy Couturier, Nicolas Rouhier
Summary: Protein import and oxidative folding within the intermembrane space of mitochondria rely on the MIA40-ERV1 couple. While MIA40 is essential in most eukaryotes, it is dispensable in Arabidopsis thaliana due to the presence of glutathione, which supports the oxidation of MIA40 substrates by AtERV1.
Review
Biochemistry & Molecular Biology
Sarah Larrigan, Sujay Shah, Alex Fernandes, Pierre Mattar
Summary: During brain development, the genome is repeatedly reconfigured to aid neuronal and glial differentiation, with a range of chromatin remodeling complexes facilitating the process. The non-redundancy of these complexes suggests a need for a variety of remodelers with different specificities and activities in neurodevelopment. The nucleosome remodeling and deacetylase (NuRD) complex plays a key role in the biochemistry, genetics, and functions of neural progenitors and neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Economics
Tim Bollerslev
Summary: This article provides a brief history of the GARCH model and my 1986 paper published in the Journal, and discusses how the GARCH model and its applications have flourished since then. The article also briefly highlights connections to the more recent realized volatility literature.
JOURNAL OF ECONOMETRICS
(2023)
Review
Chemistry, Inorganic & Nuclear
Osman Karaman, Gizem Atakan Alkan, Caglayan Kizilenis, Cevahir Ceren Akgul, Gorkem Gunbas
Summary: This article reviews the design and synthesis strategies, key photophysical properties, application in fluorescence imaging, and limited utilization as photodynamic therapy agents of hybrid xanthene dyes that have emerged in the last decade.
COORDINATION CHEMISTRY REVIEWS
(2023)
Editorial Material
Endocrinology & Metabolism
Salim Khiati, Dominique Bonneau, Guy Lenaers
Summary: Researchers conducted panomic analyses on in-flight samples from astronauts, mice, and cells to prepare for long space trips, revealing major mitochondrial dysfunctions that affect metabolism, immunity, and circadian rhythm, prompting the evaluation of measures to reduce risks for future space journeys.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Chemistry, Physical
Wen Yang, Kaiyao Xin, Juehan Yang, Qun Xu, Chongxin Shan, Zhongming Wei
Summary: This paper provides an up-to-date review of recent research progress on new 2D UWBG semiconductor materials and their novel physical properties. The widespread applications of 2D UWBG semiconductors, such as in transistors and photodetectors, and the existing challenges and opportunities in this field are highlighted.
Article
Computer Science, Artificial Intelligence
Jun Ma, Jianan Chen, Matthew Ng, Rui Huang, Yu Li, Chen Li, Xiaoping Yang, Anne L. Martel
Summary: This paper provides a comprehensive review of segmentation loss functions in deep learning-based methods and conducts a large-scale analysis, finding that compound loss functions are the most robust. The study results suggest that no single loss function consistently outperforms others across different segmentation tasks.
MEDICAL IMAGE ANALYSIS
(2021)
Review
Ophthalmology
Peter Wostyn, Charles Robert Gibson, Thomas H. Mader
Summary: A significant proportion of astronauts develop ophthalmic abnormalities in microgravity, prompting NASA to prioritize research on spaceflight-associated neuro-ocular syndrome and recent discoveries on the ocular glymphatic system may provide key insights into the mechanisms underlying optic disc edema. This paradigm shift in understanding fluid dynamics in the eye has the potential to significantly impact future studies on the pathogenesis of optic disc edema in astronauts and develop countermeasures.
Editorial Material
Biochemistry & Molecular Biology
Wenjie Luo, Wenhui Qu, Li Gan
Summary: Decoding cellular changes in Alzheimer's disease through large cohorts with defined clinical stages is critical for understanding the diverse trajectories of AD progression. In this issue of Cell, five studies have utilized single-nuclei RNA sequencing (snRNA-seq) and single-nuclei ATAC sequencing (snATAC-seq) at an unprecedented scale, shedding light on cell-type-specific mechanisms underlying the progression of AD pathogenesis.
Article
Computer Science, Information Systems
Gerhard Weikum
Summary: Knowledge graphs, constructed from web data, have become a key asset in AI, enabling machines to understand entities and their relationships for applications such as question answering, natural language processing, and data analytics. Extracting quantitative measures of entities from text and web tables presents new opportunities to enhance the scope and value of knowledge bases.
PROCEEDINGS OF THE VLDB ENDOWMENT
(2021)
Article
Physics, Multidisciplinary
Behrouz Zolfaghari, Khodakhast Bibak, Takeshi Koshiba
Summary: This paper presents a systematic review on the applications of entropy and related information-theoretical concepts in cryptography. It discusses the design, implementation, and evaluation of cryptographic schemes, algorithms, devices, and systems. Furthermore, it explores existing trends and establishes a roadmap for future research in these areas.
Review
Immunology
Veronica Ramos-Mejia, Jose Arellano-Galindo, Juan Manuel Mejia-Arangure, Mario Ernesto Cruz-Munoz
Summary: NK cells, as unique immune cells, have the ability to recognize and eliminate transformed hematopoietic cells without prior sensitization or expansion of specific clones. Research on NK cells has made significant progress in understanding their role and characteristics. Not only do they act as effectors against specific pathogens, but they also regulate immune responses and play a crucial role in the design of strategies for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)