Article
Medicine, General & Internal
Eun-Young Lee
Summary: This study investigated the mechanisms underlying memory deficits in Parkinson's disease (PD) and their relationship with brain structural metrics. The findings showed that PD patients had lower memory capacity scores compared to controls in both memory experiments. Additionally, PD patients exhibited reduced cortical thickness in the left superior temporal gyrus, which was associated with lower memory scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
How-Wing Leung, Gabriel Wei Quan Foo, Antonius M. J. VanDongen
Summary: The immediate early gene Arc plays a crucial role in regulating synaptic function and memory consolidation. It interacts with dynamic chromatin and associates with histone markers for active enhancers and transcription in cultured rat hippocampal neurons. Upregulated histone modifications associated with late-onset Alzheimer's disease have been found. Altered expression profiles of over 1900 genes, including those involved in synaptic function, neuronal plasticity, excitability, and signaling pathways, were observed when Arc induction was prevented. About 100 Arc-dependent genes are implicated in the pathophysiology of Alzheimer's disease. The induction of endogenous Arc expression in HEK293T cells increased the transcription of neuronal genes, suggesting that Arc can control gene expression independently of activated signaling pathways. These findings establish Arc as a master regulator of activity-dependent gene expression in neurons and suggest its significance in Alzheimer's disease pathophysiology.
Review
Clinical Neurology
Anna B. Szabo, Benjamin Cretin, Fleur Gerard, Jonathan Curot, Emmanuel J. Barbeau, Jeremie Pariente, Lionel Dahan, Luc Valton
Summary: The observation of a potential pathophysiological connection between Alzheimer's disease and epilepsy is well-supported by increasing literature. Studies suggest a higher prevalence of epilepsy in Alzheimer's patients, with comorbid epilepsy potentially leading to accelerated cognitive decline. The increased occurrence of epileptic activities during sleep may provide insights into the underlying mechanisms of this comorbidity, which could interfere with sleep-related memory consolidation. This research is important for patient care and future studies.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Qiuchen Zhao, Megi Maci, Morgan R. Miller, Heng Zhou, Fang Zhang, Moustafa Algamal, Yee Fun Lee, Steven S. Hou, Stephen J. Perle, Hoang Le, Alyssa N. Russ, Eng H. Lo, Dmitry Gerashchenko, Stephen N. Gomperts, Brian J. Bacskai, Ksenia V. Kastanenka
Summary: This study demonstrates that optogenetic targeting of GABAergic interneurons rescues sleep deficits and ameliorates neuropathological and behavioral deficits in an AD mouse model.
MOLECULAR NEURODEGENERATION
(2023)
Article
Multidisciplinary Sciences
Nitin S. Chouhan, Leslie C. Griffith, Paula Haynes, Amita Sehgal
Summary: Sleep plays an important role in memory consolidation, but under specific conditions like starvation, there is a memory formation mechanism that does not rely on sleep, providing an evolutionary advantage. Fruit flies are able to form sleep-dependent and sleep-independent memories based on an adaptive circuit mechanism, which demonstrates plasticity in memory circuits in response to changing environmental conditions.
Article
Cell Biology
Xing Jun Jiang, Yan Qing Wu, Rong Ma, Yan Min Chang, Lu Lu Li, Jia Hui Zhu, Gong Ping Liu, Gang Li
Summary: This study found that overexpression of PINK1 can promote the degradation of accumulated tau proteins in patients with AD, improving cognitive abilities and rescuing damaged neurons and synapses. Furthermore, PINK1 also improves mitochondrial dysfunction caused by tau proteins. This suggests that PINK1 may be a potential target for AD treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Xuemeng Miao, Qian Wu, Siyu Du, Ludan Xiang, Siyao Zhou, Junzhe Zhu, Zirun Chen, Hui Wang, Xuyi Pan, Yiren Fan, Lihan Zhang, Jingkang Qian, Yuxuan Xing, Yiyang Xie, Lixin Hu, Haiyun Xu, Wei Wang, Ying Wang, Zhihui Huang
Summary: Neuroinflammation is crucial in the development and progression of Alzheimer's disease (AD), and SARM1 is known to promote axonal degeneration and be involved in neuroinflammation. This study showed that SARM1 was reduced in hippocampal neurons of AD model mice. Conditional knockout of SARM1 in the central nervous system delayed cognitive decline, reduced A beta deposition and inflammatory infiltration, and inhibited neurodegeneration in AD model mice. Further investigation revealed the downregulation of the TNF-alpha pathway in the hippocampus of SARM1 knockout mice, which alleviated cognitive decline, A beta deposition, and inflammatory infiltration.
Review
Health Care Sciences & Services
Clemens Scott Kruse, Keya Sen, Valery Armenta, Nicole Hubbard, Rebekah Brooks
Summary: mHealth and VR are effective interventions for memory care in AD patients. These interventions improve cognition, memory, brain activity, language, and depression. However, barriers such as cost, time, training, and low reimbursement hinder the adoption of these interventions.
Article
Pharmacology & Pharmacy
Lin Zhu, Fangjin Lu, Xiaoran Zhang, Siyuan Liu, Ping Mu
Summary: The study found that Pterostilbene (PTE) in blueberries has neuroprotective properties in the treatment of Alzheimer's disease, improving cognitive dysfunction and neuronal plasticity. Its mechanism may be related to inhibiting mitochondria-dependent apoptosis through the antioxidant effect regulated by SIRT1/Nrf2.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Na Li, Mingru Deng, Gonghui Hu, Nan Li, Haicheng Yuan, Yu Zhou
Summary: Alzheimer's disease is a common and irreversible neurodegenerative disease characterized by memory and cognition impairment. Microglia play a critical role in Alzheimer's disease, not only directly mediating immune response but also participating in pathological changes. Therefore, microglia have the potential to become new therapeutic targets for Alzheimer's disease.
Article
Clinical Neurology
Daniele Altomare, Sara Stampacchia, Federica Ribaldi, Szymon Tomczyk, Claire Chevalier, Geraldine Poulain, Saina Asadi, Bianca Bancila, Moira Marizzoni, Marta Martins, Aurelien Lathuiliere, Max Scheffler, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Ilse Kern, Miguel Frias, Valentina Garibotto, Giovanni B. Frisoni
Summary: This study aimed to confirm the correlations between plasma and traditional Alzheimer's disease (AD) biomarkers, assess the diagnostic accuracy of plasma biomarkers compared to traditional biomarkers, and estimate the potential savings in traditional exams by using plasma biomarkers. The results showed significant correlations between plasma biomarkers and traditional biomarkers, and high accuracy in discriminating biomarker status. The implementation of plasma biomarkers could save a significant proportion of expensive traditional exams, making the diagnostic workup more cost-effective and improving patient care.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Arit Glicksohn, Ladan Shams, Aaron R. Seitz
Summary: Memory involves encoding, consolidating, and retrieving information. Targeted memory reactivation is an experimental method that reactivates sensory components to enhance memory retrieval. In this study, participants were presented with everyday objects, some of which were tagged with sounds. Unusual objects and sounds were created as "oddballs". During a reactivation phase, participants listened to a replay of normal and oddball sounds. The results showed that participants had better memory for oddball objects, especially when their sounds were reactivated.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Hsuan-Wen Lin, Chun-Chao Chen, Ruei-Yu Jhang, Linyi Chen, J. Steven de Belle, Tim Tully, Ann-Shyn Chiang
Summary: Learned experiences need to be periodic and meaningful to be consolidated into long-term memory. The consolidation of long-term memory relies on the de novo protein synthesis mediated by cyclic AMP response element-binding protein (CREB). This study reveals that spaced training induces the expression of the crebB gene in specific neurons in the mushroom body of Drosophila, enhancing the formation of long-term memory. On the other hand, learning from weak training leads to the synthesis of the 5-HT1A serotonin receptor and inhibits long-term memory formation. The findings demonstrate that CREBB, induced by spaced training, counteracts the effect of learning-induced 5-HT1A in specific early MB neurons to regulate the consolidation of long-term memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Dustin Hammers, Sara Nemes, Taylor Diedrich, Ani Eloyan, Kala Kirby, Paul Aisen, Joel Kramer, Kelly Nudelman, Tatiana Foroud, Malia Rumbaugh, Alireza S. Atri, Gregory Day, Ranjan R. Duara, Neill S. Graff-Radford, Lawrence T. Honig, David C. Jones, Joseph F. Masdeu, Mario Mendez, Erik U. Musiek, Chiadi Onyike, Meghan Riddle, Emily Rogalski, Steve J. Salloway, Sharon J. Sha, Raymond Scott Turner, Sandra S. Weintraub, Thomas A. Wingo, David Wolk, Bonnie C. Wong, Maria C. Carrillo, Bradford D. Dickerson, Gil G. Rabinovici, Liana Apostolova
Summary: This study investigated the limitations of learning slopes in early-onset dementias and aimed to highlight the sensitivity of learning slopes in discriminating disease severity in cognitively normal participants and those diagnosed with early-onset dementia. The results showed that learning slopes are highly sensitive to early-onset dementias, even when controlling for the effect of total learning and cognitive severity. The rating for the importance of this study is 8 out of 10.
ALZHEIMERS & DEMENTIA
(2023)
Article
Plant Sciences
Jorelle Linda Kamda Damo, Razvan Stefan Boiangiu, Ion Brinza, Lea Blondelle Kenko Djoumessi, Roland Nhouma Rebe, Balbine Nkwingwa Kamleu, Simon Desire Nyayi Guedang, Guillaume Woumitna Camdi, Parfait Bouvourne, Eglantine Wado Keugong, Herve Herve Abaissou Ngatanko, Oana Cioanca, Monica Hancianu, Harquin Simplice Foyet, Lucian Hritcu
Summary: The present study investigated the potential benefits of Guiera senegalensis in improving scopolamine-induced memory impairment and brain oxidative stress in zebrafish. The results showed that Guiera senegalensis treatment reduced oxidative stress and acetylcholinesterase activity. These findings suggest that Guiera senegalensis could be a natural alternative treatment for cognitive disorders associated with Alzheimer's disease.
Article
Neurosciences
Motomi Matsuno, Junjiro Horiuchi, Yoshihiro Yuasa, Kyoko Ofusa, Tomoyuki Miyashita, Tomoko Masuda, Minoru Saitoe
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Takashi Nonaka, Genjiro Suzuki, Yoshinori Tanaka, Fuyuki Kametani, Shinobu Hirai, Haruo Okado, Tomoyuki Miyashita, Minoru Saitoe, Haruhiko Akiyama, Hisao Masai, Masato Hasegawa
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Yukinori Hirano, Kunio Ihara, Tomoko Masuda, Takuya Yamamoto, Ikuko Iwata, Aya Takahashi, Hiroko Awata, Naosuke Nakamura, Mai Takakura, Yusuke Suzuki, Junjiro Horiuchi, Hiroyuki Okuno, Minoru Saitoe
NATURE COMMUNICATIONS
(2016)
Article
Neurosciences
Shintaro Naganos, Kohei Ueno, Junjiro Horiuchi, Minoru Saitoe
Article
Neurosciences
Shoma Sato, Kohei Ueno, Minoru Saitoe, Takaomi Sakai
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Cell Biology
Keisuke Kamimura, Kohei Ueno, Jun Nakagawa, Rie Hamada, Minoru Saitoe, Nobuaki Maeda
JOURNAL OF CELL BIOLOGY
(2013)
Article
Neurosciences
Daisuke Yamazaki, Junjiro Horiuchi, Kohei Ueno, Taro Ueno, Shinjiro Saeki, Motomi Matsuno, Shintaro Naganos, Tomoyuki Miyashita, Yukinori Hirano, Hiroyuki Nishikawa, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Yoshiko Honda, Tohru Kodama, Tomoko Masuda, Minoru Saitoe
Article
Multidisciplinary Sciences
Ema Suzuki-Sawano, Kohei Ueno, Shintaro Naganos, Yoshihiro Sawano, Junjiro Horiuchi, Minoru Saitoe
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Tomoyuki Miyashita, Emi Kikuchi, Junjiro Horiuchi, Minoru Saitoe
Article
Immunology
Tomonori Suzuki, Kuniko Kohyama, Kengo Moriyama, Mariko Ozaki, Setsuko Hasegawa, Taro Ueno, Minoru Saitoe, Tomohiro Morio, Masaharu Hayashi, Hiroshi Sakuma
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Neurosciences
Kohei Ueno, Johannes Morstein, Kyoko Ofusa, Shintaro Naganos, Ema Suzuki-Sawano, Saika Minegishi, Samir P. Rezgui, Hiroaki Kitagishi, Brian W. Michel, Christopher J. Chang, Junjiro Horiuchi, Minoru Saitoe
JOURNAL OF NEUROSCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Johannes Morstein, Denis Hofler, Kohei Ueno, Jonah W. Jurss, Ryan R. Walvoord, Kevin J. Bruemmer, Samir P. Rezgui, Thomas F. Brewer, Minoru Saitoe, Brian W. Michel, Christopher J. Chang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Neurosciences
Minoru Saitoe, Shintaro Naganos, Tomoyuki Miyashita, Motomi Matsuno, Kohei Ueno
Summary: Dopamine neurons regulate brain functions through both broad transmission and on-demand transmission mechanisms. Broad transmission modulates global functions, while on-demand transmission modulates specific circuits, neurons, or synapses. In Drosophila, the on-demand transmission mechanism is used to transmit shock information and reinforcement.
NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Shintaro Naganos, Kohei Ueno, Junjiro Horiuchi, Minoru Saitoe
Summary: The ability to associate different cues with danger and safety is crucial for survival in many animals. In a study using Drosophila melanogaster, it was found that flies not only learn to avoid odours paired with electrical shocks, but also develop an approach memory for a second odour presented after the shocks. The formation and recall of this approach memory involve different brain locations and mechanisms compared to aversive and appetitive olfactory memories.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Motomi Matsuno, Junjiro Horiuchi, Kyoko Ofusa, Tomoko Masuda, Minoru Saitoe