Article
Medicine, General & Internal
Elizabeth J. Austin, Jessica Chen, Elsa S. Briggs, Lori Ferro, Paul Barry, Ashley Heald, Joseph O. Merrill, Geoffrey M. Curran, Andrew J. Saxon, John C. Fortney, Anna D. Ratzliff, Emily C. Williams
Summary: This study explores the experiences and perspectives of multidisciplinary primary care (PC) teams in initiating or expanding medication for opioid use disorder (MOUD). The results suggest that PC teams face challenges in providing rapid access to care and engaging patients with MOUD, as well as maintaining clinician confidence. Attitudes towards MOUD expansion vary among PC teams. The study highlights the need for flexibility in appointment scheduling, effective patient engagement, and ongoing training to address evolving opioid-related clinical issues.
Article
Public, Environmental & Occupational Health
Kelly R. Peck, Nathaniel Moxley-Kelly, Gary J. Badger, Stacey C. Sigmon
Summary: This study found that a history of PTSD is prevalent among individuals seeking treatment for OUD in Vermont and is associated with worse treatment outcomes. Participants with PTSD history were less likely to have received prior OUD treatment but more likely to have a primary care physician and medical insurance compared to those without PTSD history.
PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Julie M. Donohue, Marian P. Jarlenski, Joo Yeon Kim, Lu Tang, Katherine Ahrens, Lindsay Allen, Anna Austin, Andrew J. Barnes, Marguerite Burns, Chung-Chou H. Chang, Sarah Clark, Evan Cole, Dushka Crane, Peter Cunningham, David Idala, Stefanie Junker, Paul Lanier, Rachel Mauk, Mary Joan McDuffie, Shamis Mohamoud, Nathan Pauly, Logan Sheets, Jeffery Talbert, Kara Zivin, Adam J. Gordon, Susan Kennedy
Summary: The study found that the prevalence of medication use for the treatment of opioid use disorder among Medicaid enrollees in 11 states in the US increased from 2014 through 2018. Further research is needed to understand the situation in other states.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Substance Abuse
Canyon Foot, Philip T. Korthuis, Judith I. Tsui, Sean X. Luo, Brian Chan, Ryan R. Cook
Summary: The aim of this study was to investigate the impact of ongoing stimulant use on the return to illicit opioid use after medication for opioid use disorder (MOUD) initiation. The findings suggest that individuals who use stimulants are more likely to relapse to ongoing non-prescribed opioid use, especially among those who initiate buprenorphine.
Article
Substance Abuse
Yih-Ing Hser, Yuhui Zhu, Zhe Fei, Larissa J. Mooney, Elizabeth A. Evans, Annemarie Kelleghan, Abigail Matthews, Caroline Yoo, Andrew J. Saxon
Summary: Among adults with comorbid opioid use disorder and mental disorders, treatment with buprenorphine-naloxone produced greater reductions in opioid use than treatment with methadone.
Article
Public, Environmental & Occupational Health
Michelle R. Lofwall, Laura C. Fanucchi
Summary: The opioid epidemic is worsening, with treatment access issues, especially in rural areas. The development of new LAB injectables holds promise to improve treatment access and retention.
PREVENTIVE MEDICINE
(2021)
Article
Substance Abuse
Lewei A. Lin, Amy S. B. Bohnert, Frederic C. Blow, Adam J. Gordon, Rosalinda V. Ignacio, H. Myra Kim, Mark A. Ilgen
Summary: This study found that the majority of Veterans diagnosed with opioid use disorder in 2017 appeared to have at least one comorbid substance use disorder, and many also had multiple substance use disorders. Despite a higher likelihood of visiting a substance use disorder clinic, having a non-opioid substance use disorder was associated with a lower likelihood of receiving buprenorphine treatment, highlighting the importance of addressing polysubstance use in efforts to expand treatment for opioid use disorder.
Article
Substance Abuse
Erin J. J. Stringfellow, Tse Yang Lim, Huiru Dong, Ziyuan Zhang, Mohammad S. S. Jalali
Summary: This study aimed to analyze the trends in buprenorphine receipt and the number of buprenorphine-waivered providers in the United States from 2003 to 2021, and examine whether the relationship between the two changed after capacity-building strategies were implemented in 2017. The findings showed that although there was an increase in the number of waivered providers, the growth in buprenorphine receipt by patients through retail pharmacies was not significant.
Article
Psychiatry
Michelle Eglovitch, Anna Beth Parlier-Ahmad, Catherine Legge, Sajanee Chithranjan, Saisriya Kolli, Stephanie Violante, Joseph M. Dzierzewski, Andrew Stephen Huhn, Allison Wilkerson, Caitlin Eileen Martin
Summary: This study examines the acceptability and patient preferences for sleep interventions among women in OUD treatment. The findings suggest that many women receiving OUD treatment experience insomnia symptoms and desire both pharmacologic and behavioral sleep interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Barbara Andraka-Christou, Olivia Golan, Rachel Totaram, Maggie Ohama, Brendan Saloner, Adam J. Gordon, Bradley D. Stein
Summary: A study on the laws and regulations of the United States found that there were no prior authorization prohibitions for MOUDs between 2005 and 2015. However, by 2019, fifteen states had implemented such prohibitions. The approach to prohibiting MOUD prior authorization varied significantly among states.
ANNALS OF MEDICINE
(2023)
Article
Substance Abuse
Allison Sugarman, Alexandria Vittitow, Anna Cheng, Mia Malone, Ryan McDonald, Nancy Pace, Ololade Williams, Babak Tofighi, Jennifer McNeely, Daniel Schatz, Timothy Roberts, Spencer Phillips Hey, Kathleen Garrity, Kristin Lindquist, Joshua D. Lee
Summary: This article presents an evidence map on interventions for opioid use disorder (OUD), aiming to summarize interventional and observational trials assessing the treatment of OUD and common clinical outcomes. The map identifies the most studied OUD interventions, such as methadone, buprenorphine, and naltrexone, and highlights the importance of pharmacologic interventions in reducing opioid use for OUD.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Public, Environmental & Occupational Health
Lisa M. Letourneau
Summary: Rural states and communities are facing significant challenges in addressing the ongoing opioid epidemic and implementing strategies for prevention and treatment tailored for their unique needs. Evidence-based approaches and tailored options are crucial for the success of combating this deadly epidemic in rural areas.
PREVENTIVE MEDICINE
(2021)
Article
Surgery
William J. Olney, Eric G. Johnson, Cassidy Potts, J. Thomas Murphy, Douglas R. Oyler
Summary: This study evaluated the impact of perioperative continuation of buprenorphine on the use of opioid medications in patients with substance use disorder. The results showed that 43.4% of patients who continued buprenorphine did not use opioid medications during days 1-7 of admission, compared to only 3.1% of patients who withheld buprenorphine. The study concluded that perioperative continuation of buprenorphine reduces the use of opioid medications without affecting pain scores.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Psychology, Clinical
Catherine Baxley, Brian Borsari, Jill V. Reavis, Jennifer K. Manuel, Ellen Herbst, William Becker, David Pennington, Steven L. Batki, Karen Seal
Summary: The study found that buprenorphine and buprenorphine/naloxone can reduce craving in individuals with opioid use disorder compared to placebo. However, lower doses of buprenorphine are associated with higher levels of craving. Compared to other medications, buprenorphine and buprenorphine/naloxone show greater levels of craving compared to methadone, while buprenorphine/naloxone is also associated with greater craving compared to extended-release naltrexone. This suggests that craving decreases over time with opioid medications, but other medications may be more effective in reducing craving.
ADDICTIVE BEHAVIORS
(2023)
Article
Substance Abuse
Milja Heikkinen, Heidi Taipale, Antti Tanskanen, Ellenor Mittendorfer-Rutz, Markku Lahteenvuo, Jari Tiihonen
Summary: This study aimed to investigate the effectiveness of buprenorphine and methadone in treating opioid use disorder (OUD) in real-world settings. The results showed that both buprenorphine and methadone were associated with a significantly lower risk of OUD-related hospitalization and death due to various causes, compared to non-use of these medications.
Article
Substance Abuse
John (Jake) Magel, Gerald Cochran, Nancy West, Julie M. Fritz, Mark D. Bishop, Adam J. Gordon
Summary: The study evaluated physical therapists' attitudes towards managing patients with POMM and found that greater role adequacy and legitimacy attitudes were associated with more confidence in POMM-related management abilities and engaging in POMM-related management practices more frequently.
Article
Social Work
Aerin J. DeRussy, Audrey L. Jones, Erika L. Austin, Adam J. Gordon, Lillian Gelberg, Sonya E. Gabrielian, Kevin R. Riggs, John R. Blosnich, Ann Elizabeth Montgomery, Sally K. Holmes, Allyson L. Varley, April E. Hoge, Stefan G. Kertesz
Summary: This study described the recruitment and response to a national survey of Veterans with homeless experience. The findings indicated that a national mailed survey approach is feasible and successful for reaching VA patients who have recently experienced homelessness, providing insight into how health systems can obtain perspectives of socially disadvantaged groups.
JOURNAL OF SOCIAL DISTRESS AND THE HOMELESS
(2023)
Article
Medicine, General & Internal
Gwen T. Lapham, Theresa E. Matson, David S. Carrell, Jennifer F. Bobb, Casey Luce, Malia M. Oliver, Udi E. Ghitza, Clarissa Hsu, Kendall C. Browne, Ingrid A. Binswanger, Cynthia I. Campbell, Andrew J. Saxon, Ryan Vandrey, Gillian L. Schauer, Rosalie Liccardo Pacula, Michael A. Horberg, Steffani R. Bailey, Erin A. McClure, Katharine A. Bradley
Summary: This study aimed to investigate the prevalence of medical cannabis use in primary care and compared it with the documentation in patient electronic health records (EHR). The findings indicate that medical cannabis use is common among primary care patients in a state where it is legal, but most of the use is not documented in the EHR. Patient report of health reasons for cannabis use identifies more medical use compared with explicit questions about medical use.
Article
Substance Abuse
George Sam Wang, Christine Buttorff, Asa Wilks, Daniel Schwam, Gregory Tung, Rosalie Liccardo Pacula
Summary: Psychosis and schizophrenia-related emergency department visits have increased in the United States in the past decade, with a strong dose-response relationship found between chronic use of high-potency cannabis and symptoms of psychosis. This study evaluates the impact of cannabis legalization on such ED visits in Colorado and finds a positive association between the number of cannabis dispensaries and rates of psychosis ED visits across all counties in the state.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Public, Environmental & Occupational Health
Austin C. Cohrs, Diah E. Husnul Khotimah, Andrew W. Dick, Bradley D. Stein, Rosalie Liccardo Pacula, Benjamin G. Druss, Kyungha Kim, Douglas L. Leslie
Summary: Little is known about the variation of opioid-related problems among U.S. adolescents and young adults across geographic regions and over time. This study analyzed longitudinal claims data from privately insured individuals aged 12-64 years with an ORP diagnosis between 2005 and 2018. The prevalence of opioid-related problem diagnoses varied considerably across census divisions and between age groups. Understanding the origin and variation of diagnosed opioid-related problems in terms of age group and geographic region is crucial for targeted and effective interventions and policies.
PREVENTIVE MEDICINE
(2022)
Article
Substance Abuse
David Hammond, Samantha Goodman, Elle Wadsworth, Tom P. Freeman, Beau Kilmer, Gillian Schauer, Rosalie Liccardo Pacula, Wayne Hall
Summary: Dried flower remains the most commonly used cannabis product in Canada and the United States, but the use of processed products has increased, especially in legal cannabis markets.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Medicine, General & Internal
Barbara Andraka-Christou, Olivia Golan, Rachel Totaram, Maggie Ohama, Brendan Saloner, Adam J. Gordon, Bradley D. Stein
Summary: A study on the laws and regulations of the United States found that there were no prior authorization prohibitions for MOUDs between 2005 and 2015. However, by 2019, fifteen states had implemented such prohibitions. The approach to prohibiting MOUD prior authorization varied significantly among states.
ANNALS OF MEDICINE
(2023)
Letter
Substance Abuse
Jakob Manthey, Michael J. Armstrong, Tobias Hayer, Daniel T. Myran, Rosalie Liccardo Pacula, Rosario Queirolo, Jurgen Rehm, Marielle Wirth, Frank Zobel
Article
Substance Abuse
Olivia K. Golan, Flora Sheng, Andrew W. Dick, Mark Sorbero, Daniel J. Whitaker, Barbara Andraka-Christou, Therese Pigott, Adam J. Gordon, Bradley D. Stein
Summary: This study examines the impact of the Affordable Care Act Medicaid expansion on the initiation rates of buprenorphine, a medication used to treat opioid use disorder. The results show that the expansion reduced income-related disparities in urban counties but had no significant effect in rural counties.
DRUG AND ALCOHOL DEPENDENCE REPORTS
(2023)
Article
Pharmacology & Pharmacy
Elle Wadsworth, Pete Driezen, Rosalie Liccardo Pacula, Beau Kilmer, David Hammond
Summary: The price of cannabis is significantly influenced by its legal status and the presence of retail stores. After the legalization of recreational cannabis, it takes multiple years for the legal market to establish, with an increase in the number of retail stores and a decrease in prices. Consumers tend to use legally accessible sources for their purchases, suggesting the potential for expanding legal sources through the addition of physical retail stores and online delivery services in states with recreational cannabis laws.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Health Care Sciences & Services
Rosanna Smart, Sean Grant, Adam J. Gordon, Rosalie Liccardo Pacula, Bradley D. Stein
Summary: This study examines expert consensus on the effectiveness and implementability of state-level opioid use disorder treatment policies. The experts identified two high-value policies: facilitated access to medications for OUD and automatic Medicaid enrollment for citizens returning from correctional settings. They also identified four low-value policies as ineffective and difficult to implement: coerced drug treatment, involuntary civil commitment, drug toxicology testing requirements, and office-based buprenorphine treatment counseling corequirements.
Article
Health Care Sciences & Services
Evan D. Peet, David Powell, Rosalie Liccardo Pacula
Summary: The study analyzed US naloxone claims data from 2010 to 2018 and found that out-of-pocket costs for naloxone have increased significantly since 2016, particularly for uninsured patients and the Evzio brand. This highlights that the out-of-pocket cost of naloxone has become a significant barrier to access for uninsured patients.
Meeting Abstract
Substance Abuse
R. Smart, R. L. Pacula, M. C. Lira, J. G. Blanchette, T. S. Naimi
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Criminology & Penology
Barbara Andraka-Christou, Olivia Randall-Kosich, Matthew Golan, Rachel Totaram, Brendan Saloner, Adam J. Gordon, Bradley D. Stein
Summary: Since 2005, only nine states have laws related to MOUD in problem-solving courts. There are two main categories of state laws: those that prohibit MOUD bans and those that potentially facilitate access to MOUD.
Review
Substance Abuse
Rosalie Liccardo Pacula, Rosanna Smart, Marlene C. Lira, Seema Choksy Pessar, Jason G. Blanchette, Timothy S. Naimis
Summary: The impact of cannabis policy liberalization on alcohol use and its related outcomes remains inconclusive. While some studies found a decrease in alcohol use measures associated with cannabis policy liberalization, there was no impact on cannabis use itself. This paper discusses the limitations of the current evidence base and suggests improvements for future research to ensure consistency and comparability.
ALCOHOL RESEARCH-CURRENT REVIEWS
(2022)