Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization

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Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

(2014) Lawrence M. Gelbert et al.   INVESTIGATIONAL NEW DRUGS

Biphenyl-4-carboxylic Acid [2-(1H-Indol-3-yl)-ethyl]-methylamide (CA224), a Nonplanar Analogue of Fascaplysin, Inhibits Cdk4 and Tubulin Polymerization: Evaluation of in Vitro and in Vivo Anticancer Activity

(2014) Sachin Mahale et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclin-Dependent Kinase 4/6–Specific Activities as a Biomarker for Prognosis and Chemosensitivity in Endometrial Cancer

(2014) Yujio Ikeda et al.   OBSTETRICS AND GYNECOLOGY

The Cell-Cycle Regulator CDK4: An Emerging Therapeutic Target in Melanoma

(2013) K. E. Sheppard et al.   CLINICAL CANCER RESEARCH

Phase II Trial of the CDK4 Inhibitor PD0332991 in Patients With Advanced CDK4-Amplified Well-Differentiated or Dedifferentiated Liposarcoma

(2013) Mark A. Dickson et al.   JOURNAL OF CLINICAL ONCOLOGY

Abstract 3054: P1446A-05: a new oral cyclin-dependent kinase inhibitor with potent preclinical antitumor activity

(2012) Kalpana S. Joshi et al.   CANCER RESEARCH

FASCAPLYSIN as a Specific Inhibitor for CDK4: Insights from Molecular Modelling

(2012) Muhammad Imtiaz Shafiq et al.   PLoS One

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors

(2012) Young Shin Cho et al.   ACS Medicinal Chemistry Letters

Recent Research in Selective Cyclin-Dependent Kinase 4 Inhibitors for Anti-Cancer Treatment

(2009) Ning Liu et al.   CURRENT MEDICINAL CHEMISTRY

Discovery of 4-(Benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(Pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4

(2009) Hwei-Ru Tsou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of human CDK4 in complex with a D-type cyclin

(2009) P. J. Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Ligand and Structure Based Approaches for Narrowing on the Essential Physicochemical Characteristics for CDK4 Inhibition

(2008) Nahren Manuel Mascarenhas et al.   Journal of Chemical Information and Modeling

4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)

(2008) Hwei-Ru Tsou et al.   JOURNAL OF MEDICINAL CHEMISTRY